Journal•ISSN: 0008-4212
Canadian Journal of Physiology and Pharmacology
NRC Research Press
About: Canadian Journal of Physiology and Pharmacology is an academic journal published by NRC Research Press. The journal publishes majorly in the area(s): Angiotensin II & Insulin. It has an ISSN identifier of 0008-4212. Over the lifetime, 10103 publications have been published receiving 213558 citations. The journal is also known as: Journal canadien de physiologie et pharmacologie & Revue canadienne de physiologie et pharmacologie.
Topics: Angiotensin II, Insulin, Blood pressure, Calcium, Receptor
Papers published on a yearly basis
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TL;DR: An approach to acid-base which revolutionizes the authors' ability to understand, predict, and control what happens to hydrogen ions in living systems is outlined and some of its most useful implications are suggested.
Abstract: Quantitative analysis of ionic solutions in terms of physical and chemical principles has been effectively prohibited in the past by the overwhelming amount of calculation it required, but computers have suddenly eliminated that prohibition. The result is an approach to acid-base which revolutionizes our ability to understand, predict, and control what happens to hydrogen ions in living systems. This review outlines that approach and suggests some of its most useful implications. Quantitative understanding requires distinctions between independent variables (in body fluids: pCO2, net strong ion charge, and total weak acid, usually protein), and dependent variables [( HCO-3], [HA], [A-], [CO(2-)3], [OH-], and [H+] (or pH]. Dependent variables are determined by independent variables, and can be calculated from the defining equations for the specific system. Hydrogen ion movements between solutions can not affect hydrogen ion concentration; only changes in independent variables can. Many current models for ion movements through membranes will require modification on the basis of this quantitative analysis. Whole body acid-base balance can be understood quantitatively in terms of the three independent variables and their physiological regulation by the lungs, kidneys, gut, and liver. Quantitative analysis also shows that body fluids interact mainly by strong ion movements through the membranes separating them.
1,274 citations
TL;DR: It is suggested that the "dysfunction" that is characteristic of several types of chronic musculoskeletal pain is a normal protective adaptation and is not a cause of pain.
Abstract: Articles describing motor function in five chronic musculoskeletal pain conditions (temporomandibular disorders, muscle tension headache, fibromyalgia, chronic lower back pain, and postexercise mus...
986 citations
TL;DR: Flow to heart and to muscles involved in respiratory movements was two to five times greater during calorigenesis and flow to most other tissues and organs increased or decreased by less than 40%.
Abstract: Cardiac output (CO) and the fractional distribution (FD) of γ-labeled plastic microspheres (15 ± 5 μm) injected into the left ventricle were used to calculate blood flow to organs and tissues of ba...
644 citations
TL;DR: D2O and deuterated drugs are widely used in studies of metabolism of drugs and toxic substances in humans and other animals, and most are more resistant to metabolic changes, especially those changes mediated by cytochrome P450 systems.
Abstract: Since the discovery of D2O (heavy water) and its use as a moderator in nuclear reactors, its biological effects have been extensively, although seldom deeply, studied. This article reviews these ef...
578 citations
TL;DR: Radioactive microspheres (12–16 μm) were used to measure cardiac output, its fractional distribution, and hence tissue blood flow in conscious, warm-acclimated or cold-acClimated white rats exposed to temperatures of 25, 21, 6, −6, and −19 °C, the objective being to assess the tissue distribution of cold-induced thermogenesis.
Abstract: Radioactive microspheres (12–16 μm) were used to measure cardiac output (CO), its fractional distribution, and hence tissue blood flow in conscious, warm-acclimated (WA) or cold-acclimated (CA) whi...
502 citations