Showing papers in "Cancer Cell in 2003"

TL;DR: Overexpression of this bone metastasis gene set is superimposed on a poor-prognosis gene expression signature already present in the parental breast cancer population, suggesting that metastasis requires a set of functions beyond those underlying the emergence of the primary tumor.

TL;DR: It is found that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer.

TL;DR: The emerging roles of the mammalian Chk1 and Chk2 kinases are discussed as key signal transducers within the complex network of genome integrity checkpoints, as candidate tumor suppressors disrupted in sporadic as well as some hereditary malignancies and as potential targets of new anticancer therapies.

TL;DR: It is shown that hypoxia promotes tumor invasion by sensitizing cells to HGF stimulation, providing a molecular basis to explain Met overexpression in cancer.

TL;DR: This work aims to provide a systematic literature review and meta-analyses of the determinants of breast cancer recurrence and prognosis in mice using a simple, scalable, and scalable approach.

TL;DR: Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those "signature" genes associated with human cancer metastasis.

TL;DR: A quantitative model of the aberrant cell cycle regulation in MCL is proposed that provides a rationale for the design of cell cycle inhibitor therapy in this malignancy.

TL;DR: It is reported that Puma is essential for hematopoietic cell death triggered by ionizing radiation, deregulated c-Myc expression, and cytokine withdrawal, and required for IR-induced death throughout the developing nervous system and accounts for nearly all of the apoptotic activity attributed to p53 under these conditions.

TL;DR: Evidence is presented that the attenuated vesicular stomatitis strains, AV1 and AV2, embody all of the traits of an oncolytic virus, which will replicate preferentially in malignant cells, have the ability to treat disseminated metastases, and ultimately be cleared by the patient.

TL;DR: It is found that overexpressing hTERT and either E7 or LT increased expression of topoisomerase 2alpha and that overeXpressing RAS(V12) and ST both increased expressionof topoisomersase 1 and sensitized cells to a nonapoptotic cell death process initiated by erastin.

TL;DR: To define Myc's functional role, transgenic mice expressing human c-Myc in the mouse prostate are generated and this approach illustrates how genomic technologies can be applied to mouse cancer models to guide evaluation of human tumor databases.

TL;DR: These data establish 2ME2 as a small molecule inhibitor of HIF-1 and provide a mechanistic link between the disruption of the MT cytoskeleton and inhibition of angiogenesis.

TL;DR: It is suggested that Notch mediates the tumor-initiating effects of TG alpha by expanding a population of undifferentiated precursor cells.

TL;DR: It is proposed that EGF-induced negative regulation of caveolin-1 plays a central role in the complex cellular changes leading to metastasis.

TL;DR: In this article, the ribosomal protein L11 can interact with HDM2 and inhibit its function, thus leading to the stabilization and activation of p53 in response to perturbations in ribosome biogenesis.

TL;DR: It is shown that elevated Aurora-A expression at levels that reflect cancer-associated gene amplification overrides the checkpoint mechanism that monitors mitotic spindle assembly, inducing resistance to the chemotherapeutic agent paclitaxel (Taxol) in a human cancer cell line.

TL;DR: In mice, expression of K-ras(V12) throughout the body fails to induce unscheduled proliferation or other growth abnormalities for up to eight months, indicating that neoplastic growth induced by an endogenous K- Ras oncogene depends upon cellular context.

TL;DR: It is apparent that Hsp90 inhibitors are unique in that, although they are directed toward a specific molecular target, they simultaneously inhibit multiple signaling pathways on which cancer cells depend for growth and survival, thereby perhaps circumventing the characteristic genetic plasticity of cancer cells.

TL;DR: It is shown that chemical or genetic ablation of human Chk1 triggered supraphysiological accumulation of the S phase-promoting CDC25A phosphatase, prevented ionizing radiation (IR)-induced degradation of Cdc25A, and caused radioresistant DNA synthesis (RDS).

TL;DR: A mouse model for neuroendocrine lung tumors is established by conditional inactivation of Rb1 and Trp53 in mouse lung epithelial cells that developed with high incidence aggressive lung tumors with striking morphologic and immunophenotypic similarities to SCLC.

TL;DR: Results indicate that MMP-generated fragments of basement membrane collagen can have endogenous function as integrin-mediated suppressors of pathologic angiogenesis and tumor growth.

TL;DR: It is found that TSC2 regulates VEGF through mTOR-dependent and -independent pathways, and this pathway may involve chromatin remodeling since the HDAC inhibitor Trichostatin A downregulates V EGF in T SC2(-/-) cells.

TL;DR: This study provides a novel mechanism by which the loss of PTEN can functionally control "two" hits in the course of tumor development by concurrently modulating p53 activity.

TL;DR: It remains to be determined to what extent toxicity to normal tissues will limit application of apoptosis-based therapies for cancer treatment, and hope that improved clinical outcomes may not be far from realization is offered.

TL;DR: Surprisingly, osteosarcomas and Rb-negative cervical cancers continued to proliferate after depletion of CDK2 through antisense oligonucleotides or small interfering (si) RNA, and it is suggested thatCDK2 is not a suitable target for cancer therapy.

TL;DR: It is now apparent that the transcriptional effects of HDIs may be but one facet of their action, and a combination of basic, clinical, and translational studies will ultimately determine the clinical utility of these agents and their mechanism of action.

TL;DR: The benefits of combining PDGF antagonists and VEGF antagonists in a mouse model of pancreatic islet cancer are shown in a report by Bergers et al.

TL;DR: The findings suggest that Oct-3/4 is not only a distinctive immunohistochemical marker for GCTs, but also plays a critical role in the genesis of these tumors.

TL;DR: This paper presents a meta-analyses of the response of the immune system to various types of chemotherapy treatments and shows clear patterns of decline in the number of immune-related adverse events and in the severity of these events.

TL;DR: Protein microarrays, one emerging class of proteomic technologies, have broad applications for discovery and quantitative analysis and is now employed for the analysis of biopsy samples in clinical trial research.