Showing papers in "Cancer Cell in 2004"

TL;DR: In this paper, PTEN activation contributes to trastuzumab's antitumor activity and PI3K inhibitors rescued PTEN loss-induced trastusumab resistance.

TL;DR: The NF-kappaB proteins themselves and proteins regulated by it have been linked to cellular transformation, proliferation, apoptosis suppression, invasion, angiogenesis, and metastasis as mentioned in this paper.

TL;DR: Despite the dramatic gene expression changes in all cell types, genetic alterations were detected only in cancer epithelial cells and chemokines may play a role in breast tumorigenesis by acting as paracrine factors.

TL;DR: It is shown that VEGFR2 blockade creates a "normalization window"--a period during which combined radiation therapy gives the best outcome, characterized by an increase in tumor oxygenation, which is known to enhance radiation response.

TL;DR: Evidence is provided that Gr+CD11b+ cells of immune origin induced by tumors directly contribute to tumor growth and vascularization by producing MMP9 and differentiating into ECs.

TL;DR: The 3.2 A X-ray crystal structure of the extracellular domain of the human epidermal growth factor receptor 2 (ErbB2 or HER2) in a complex with the antigen binding fragment of pertuzumab, an anti-Erb B2 monoclonal antibody, is determined.

TL;DR: It is reported that LKB1 is required for repression of mTOR under low ATP conditions in cultured cells in an AMPK- and TSC2-dependent manner, and that L KB1 null MEFs and the hamartomatous gastrointestinal polyps from Lkb1 mutant mice show elevated signaling downstream of m TOR.

TL;DR: An expression signature predictive of disease-free survival was reduced to a two-gene ratio, HOXB13 versus IL17BR, which outperformed existing biomarkers and may be useful for identifying patients appropriate for alternative therapeutic regimens in early-stage breast cancer.

TL;DR: Novel pathways contributing significantly to the understanding of HIF-1 regulation which may be major determinants of tumor radiosensitivity, potentially having high clinical relevance are described.

TL;DR: Rapid progress made is reviewed in the understanding of B-RAF as an oncogene and of its role in cancer.

TL;DR: It is demonstrated that the conditional expression of an endogenous K-ras(G12D) allele in murine embryonic fibroblasts causes enhanced proliferation and partial transformation in the absence of further genetic abnormalities.

TL;DR: Efficacy and safety results from a phase 2 clinical trial contributed to approval of bortezomib for use in patients with relapsed and refractory multiple myeloma who have received at least 2 prior therapies and have demonstrated disease progression on their last therapy.

TL;DR: Using a tumor xenograft model, it is shown that Ras-dependent CXCL-8 secretion is required for the initiation of tumor-associated inflammation and neovascularization and a novel mechanism by which the Ras oncogene can elicit a stromal response that fosters cancer progression.

TL;DR: It is demonstrated that some, but not all, leukemia oncogenes can confer properties of leukemic stem cells to hematopoietic progenitors destined to undergo apoptotic cell death.

TL;DR: These compounds meet predicted criteria for disrupting Tcf/beta-catenin complexes and define a general standard to establish mechanism-based activity of small molecule inhibitors of this pathogenic protein-protein interaction.

TL;DR: NVP-ADW742 monotherapy or its combination with cytotoxic chemotherapy had significant antitumor activity in an orthotopic xenograft MM model, providing in vivo proof of principle for therapeutic use of selective IGF-1R inhibitors in cancer.

TL;DR: It is shown that gene expression patterns from 60 HNSCC samples assayed on cDNA microarrays allowed categorization of these tumors into four distinct subtypes, which showed statistically significant differences in recurrence-free survival and included a subtype with a possible EGFR-pathway signature.

TL;DR: Gene expression profiling of pancreatic islet tumors in a mouse model of cancer revealed upregulation of cathepsin cysteine proteases, encouraging consideration of this protease family as a therapeutic target in human cancers.

TL;DR: The role of NF-kappaB in inflammation-induced tumor growth is investigated in an experimental murine cancer metastasis model and it is found that LPS-induced metastatic growth response in this model depends on both TNFalpha production by host hematopoietic cells and NF- kappaB activation in tumor cells.

TL;DR: It is determined that perturbation of two signaling pathways-involving p53 and Raf-suffices for the tumorigenic conversion of normal murine fibroblasts, while perturbations of six pathways- involvingp53, pRb, PP2A, telomerase, Raf, and Ral-GEFs-is needed for human fibro Blasts.

TL;DR: The proto-oncogene c-src is rarely mutated in human cancers, and when overexpressed in normal cells is non- or weakly oncogenic, which has raised doubts about the involvement of c- src in the etiology of human tumors.

TL;DR: NVP-AEW541 represents a class of selective, small molecule IGF-IR kinase inhibitors with proven in vivo antitumor activity and potential therapeutic application and abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-ir autophosphorylation.

TL;DR: This work was supported by a grant from Red Tematica del Cancer, Instituto de Salud Carlos III (grant number C03/10) and the sponsors had no part in the research or writing of this paper.

TL;DR: In this article, the authors demonstrate that Galectin-1 signaling in activated T cells constitutes an important mechanism of tumor-immune escape and that blockade of this inhibitory signal can allow for and potentiate effective immune responses against tumor cells, with profound implications for cancer immunotherapy.

TL;DR: A mouse model of medulloblastoma is used to show that inhibition of the Sonic Hedgehog (Shh) pathway provides a novel therapy for medullOBlastoma, and support the development of Shh antagonists for the treatment of this cancer.

TL;DR: It is shown that HER2 enhances the expression of CXCR4, which is required for HER2-mediated invasion in vitro and lung metastasis in vivo, and this work establishes a functional link between HER2 and CX CR4 signaling pathways.

TL;DR: This work profiled mRNA expression of the 48 known human ABC transporters in 60 diverse cancer cell lines used by the National Cancer Institute and found and validated compounds whose activity is potentiated, rather than antagonized, by the MDR1 multidrug transporter.

TL;DR: It is demonstrated that the survival-promoting function is crucial for periostin to promote tumor metastasis of colon cancer.

TL;DR: In this paper, the authors showed that specific Ang2 inhibition may represent an effective anti-angiogenic strategy for treating patients with solid tumors, and they showed that anti-Ang2 therapy also prevented VEGF-stimulated neovascularization in a rat corneal model of angiogenesis.

TL;DR: In this article, the authors report that members of the PDGF family act as lymphangiogenic factors, and that PDGF-BB stimulated MAP kinase activity and cell motility of isolated lymphatic endothelial cells.