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Showing papers in "Cancer Letters in 2008"


Journal ArticleDOI
TL;DR: The present work demonstrates the feasibility of in vivo PPTT treatment of deep-tissue malignancies using easily-prepared plasmonic gold nanorods and a small, portable, inexpensive near-infrared (NIR) laser.

1,097 citations


Journal ArticleDOI
TL;DR: The activity of curcumin reported against leukemia and lymphoma, gastrointestinal cancers, genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, melanoma, neurological cancers, and sarcoma reflects its ability to affect multiple targets.

1,014 citations


Journal ArticleDOI
TL;DR: Curcumin has been found to inhibit the proliferation of various tumor cells in culture, prevents carcinogen-induced cancers in rodents, and inhibits the growth of human tumors in xenotransplant or orthOTransplant animal models either alone or in combination with chemotherapeutic agents or radiation.

1,006 citations


Journal ArticleDOI
TL;DR: In this review, the latest developments on the anti-carcinogenic activities of anthocyanin-rich extracts in cell culture models and in animal model tumor systems are summarized, and their molecular mechanisms of action are discussed.

911 citations


Journal ArticleDOI
TL;DR: Dietary quercetin is a promising agent for cancer prevention and further research is warranted, as it prevents chemically induced carcinogenesis and modulates several signal transduction pathways involving MEK/ERK and Nrf2/keap1.

621 citations


Journal ArticleDOI
TL;DR: The role of CXC chemokines and their receptors in tumorigenesis, including angiogenesis, attraction of leukocytes to tumor sites and induction of tumor cell migration and homing in metastatic sites is discussed.

597 citations


Journal ArticleDOI
TL;DR: The aim of this review is to provide an overview of the recent progress on role of ROS derived from NADPH oxidase and redox signaling events involved in angiogenesis, and to provide insight into the NADPH oxidation andRedox signaling components as potential therapeutic targets for tumorAngiogenesis.

576 citations


Journal ArticleDOI
TL;DR: Both in vivo and in vitro studies have clearly shown that genistein, one of the major soy isoflavones is a promising agent for cancer chemoprevention and further suggest that it could be an adjunct to cancer therapy by virtue of its effects on reversing radioresistance and chemoresistance.

567 citations


Journal ArticleDOI
TL;DR: Growing evidence supports a role of ROS-induced generation of oxidative stress in these epigenetic processes and as such the authors can hypothesize of potential mode(s) of action) by which oxidative stress modulates epigenetic regulation of gene expression.

551 citations


Journal ArticleDOI
TL;DR: The overall current information suggests that CCL2 and CCL5 are inflammatory mediators with pro-malignancy activities in breast cancer, and that they should be considered as potential therapeutic targets for the limitation of this disease.

537 citations


Journal ArticleDOI
TL;DR: The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches and is analyzed in detail in this review of current knowledge of TAM.

Journal ArticleDOI
TL;DR: This review will focus on the roles of the death receptor and mitochondrial pathways in anokis and anoikis resistance and how targeting defects in these pathways can restore sensitivity to ano Kikis and serve as the basis for therapeutic adjuncts that prevent metastasis.

Journal ArticleDOI
TL;DR: Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables and is especially high in broccoli and broccoli sprouts, with an emphasis on the possible chemoprevention mechanisms.

Journal ArticleDOI
TL;DR: This review summarizes the diverse molecular targets of resveratrol with a special focus on those involved in fine-tuning of orchestrated intracellular signal transduction.

Journal ArticleDOI
TL;DR: The different mechanisms of HDAC inhibitor-induced apoptosis are summarized, their use in combination with other anticancer agents are discussed, and their use with other chemotherapeutic agents is discussed.

Journal ArticleDOI
TL;DR: The protective effects of silymarin and its major active constituent, silibinin, studied in various tissues, suggest a clinical application in cancer patients as an adjunct to established therapies, to prevent or reduce chemotherapy as well as radiotherapy-induced toxicity.

Journal ArticleDOI
TL;DR: The rationale for using long-chain n-3 PUFAs in cancer prevention and treatment and the challenges that such approaches pose in the design of clinical trials are discussed.

Journal ArticleDOI
TL;DR: A precise understanding of how ROS are generated and involved in tumor metastasis will help to design better strategies to overcome such life-threatening events.

Journal ArticleDOI
TL;DR: Large amount of encouraging data from in vitro and animal models has emerged making clear that green tea is a nature's gift molecule endowed with anticancer effects, and properties of GTP are reviewed with reference to multitargeted therapy of cancer.

Journal ArticleDOI
TL;DR: Dye exclusion is a valuable technique as it identifies a unique population of cells with stem-like characteristics, and cells that exclude this dye are referred to as side population cells.

Journal ArticleDOI
TL;DR: The modulation of various molecular targets by proanthocyanidins in vitro and in vivo tumor models suggests their importance, contribution and mechanism of action to the prevention of cancers of different organs.

Journal ArticleDOI
Ling Qiao1, Zhili Xu1, Tiejun Zhao1, Lihong Ye1, Xiaodong Zhang1 
TL;DR: The finding showed that beta-catenin was down-regulated in MCF-7 cells by conditioned media from Z3 hMSCs, and the expression level of dickkopf-1 (Dkk-1) was higher in Z3 cells than that inMCF- 7 cells, suggesting that DKK-1 secreted by Z3 Cells involves the inhibition via the Wnt pathway.

Journal ArticleDOI
TL;DR: Novel anti-tumor agents with overlapping underlying mechanisms have emerged via structural optimization of indole-3-carbinol and DIM, which may provide considerable therapeutic advantages over the parental compounds with respect to chemical stability and anti-Tumor potency and foster new strategies for cancer prevention and therapy.

Journal ArticleDOI
TL;DR: This short review will try to provide a background to this emerging field by summarizing the biochemistry of ROS-mediated cell signaling and its relation to carcinogenesis, with special emphasis on the emerging role of the so called "labile" iron in ROS- mediated signaling in relation to cancer development.

Journal ArticleDOI
TL;DR: Evidence for activation of RAS/PI3K/STAT pathways, that lead to increased ROS, DNA damage and defective repair in myeloid diseases, a mechanism for acquisition of additional mutations that can drive disease progression are reviewed.

Journal ArticleDOI
TL;DR: Preclinical and limited clinical data are summarized to warrant further clinical evaluation of Allium vegetable constituents for prevention and therapy of human cancers.

Journal ArticleDOI
TL;DR: There is evidence indicating that exposure to traffic-related air pollution particles is associated with oxidative damage to DNA and this might be associated with increased risk of cancer.

Journal ArticleDOI
TL;DR: The effects of C-DIMs on PPARgamma and Nur77 coupled with their receptor-independent activities has resulted in the development of a novel group of multi-targeted anticancer drugs with excellent potential for clinical treatment of cancer.

Journal ArticleDOI
TL;DR: In clinical studies, pomegranate juice administration led to a decrease in the rate of rise of Prostate Specific Antigen after primary treatment with surgery or radiation, and continued translational research on the chemopreventive potential of poregranate ellagitannins is ongoing.

Journal ArticleDOI
TL;DR: Results indicate that miR-21 expression plays a key role in regulating cellular processes in glioblastomas and may serve as a target for effective therapies.