Showing papers in "Cancer Letters in 2009"

TL;DR: Individual HDAC family members as drug targets in cancer are discussed taking into consideration their function under physiological conditions and their oncogenic potential in malignant disease.

TL;DR: Preclinical studies conducted to determine the utility of Lupeol as a therapeutic and chemopreventive agent for the treatment of inflammation and cancer suggest that it is a multi-target agent with immense anti-inflammatory potential targeting key molecular pathways.

TL;DR: The causes for increased ROS generation and its potential role in etiology and progression of prostate cancer are summarized.

TL;DR: The emerging roles of miRNAs in the hallmarks of human cancers are discussed to provide potential diagnostic and prognostic tumor biomarkers and new therapeutic strategies to treat cancers.

TL;DR: The clinical success of selective kinase inhibitors, such as imatinib and erlotinib, as therapeutic agents for several human cancers has prompted substantial interest in the further development and clinical testing of such inhibitors for a wide variety of malignancies as mentioned in this paper.

TL;DR: Evidence is provided to show the suppression role of miR-34a in tumor migration and invasion through modulation of the c-Met signaling pathway through modification of the ERK1/2 signaling pathway.

TL;DR: The successes and challenges surrounding the development of panobinostat are discussed, focusing on its proposed mechanism of action, preclinical anti-tumor activity, and early clinical efficacy in hematologic and solid tumors.

TL;DR: Although GSK3beta is an attractive therapeutic target for a number of human diseases, its potential impact on tumorigenesis and cancer chemotherapy needs to be carefully evaluated.

TL;DR: All of the data point to a potential biological role of differences in HDAC expression in human tumours, and future translational studies will focus on the question, whetherHDAC expression patterns are predictive for response to treatment with histone deacetylase inhibitors.

TL;DR: It is shown that miR-27a is up-regulated in human gastric adenocarcinoma, and down-regulation of prohibitin by miR -27a may explain why suppression of miR,27a can inhibit gastric cancer cell growth, further supporting that miRNAs functions as an oncogene.

TL;DR: The incidence of liver cancer is high in all low-resource regions of the world, with the exception of Northern Africa and Western Asia and the increased prevalence of overweight and obesity likely contributes to it.

TL;DR: It is hypothesized that in ovarian carcinoma patients exosomes initially produced at the local abdominal site may become systemic and proposed that tumor-derived exosome could play a role in tumor progression.

TL;DR: Gallic acid is identified as the major anti-cancer compound in T. sinensis leaf extracts and it is shown to block the growth of DU145 cells at G2/M phases by activating Chk1 and Chk2 and inhibiting Cdc25C and Cdc2 activities.

TL;DR: This is the first demonstration that tumor-derived microvesicles favor the establishment of melanoma metastasis in a PS-dependent manner, possibly by down-regulating the host's inflammatory and/or anti-tumoral immune responses.

TL;DR: Results show that, the transferrin-transferrin receptor-mediated cellular uptake of gold nanoparticles is six times of that in the absence of this interaction, and the laser power effective for photothermal therapy of the cancer cells was reduced.

TL;DR: The results suggest that caspase-mediated cleavage of ATG6 links the apoptotic and autophagic signaling pathways.

TL;DR: An expanding role of Notch signaling in human tumor progression is suggested, as many cancers are thought to be developed from a number of cancer stem-like cells, which are also known to be linked with the acquisition of epithelial-mesenchymal transition (EMT).

TL;DR: The ability of HDACi to synergise with other anti-cancer agents to potently kill tumor cells and the possible molecular processes that underpin the combination effect are highlighted.

TL;DR: The role of HIF-1alpha and VEGF influence on tumor angiogenesis is discussed and how targeting HDACs via their inhibition create new avenues in treating solid malignancies by increasing the activity of established and novel therapeutic applications.

TL;DR: Curcumin suppressed the migration and invasion of human non-small cell lung cancer cells (A549) in vitro and suggests that curcumin has anti-metastatic potential by decreasing invasiveness of cancer cells.

TL;DR: The selectivity and toxicity of HDAC inhibitors currently in clinic are examined, comparing pan-HDAC inhibitors to Class I selective compounds, and the rationale for isoform-specific inhibitors is examined.

TL;DR: There are evidences that occult HBV is a risk factor for the development of HCC and that the potential mechanisms whereby overt HBV might induce tumour formation are mostly maintained.

TL;DR: Current evidence suggests that coffee consumption is associated with a reduced risk of liver, kidney, and to a lesser extent, premenopausal breast and colorectal cancers, while it is unrelated to prostate, pancreas and ovary cancers.

TL;DR: It is demonstrated that PCL induces apoptosis and autophagy via a mitochondrial-mediated ROS-p38-p53 pathway in A375 cells, and it is confirmed that the ROS- p38- p53 pathway was involved in PCL-inducedAutophagy.

TL;DR: Results suggested miR-138 acts as a tumor suppresser and may serve as a therapeutic target for HNSCC patients at risk of metastasis.

TL;DR: It is observed that exogenous hMSCs targeted the osteosarcoma site and promoted its growth and pulmonary metastasis in vivo and CCL5 was at least partly responsible for this enhancement.

TL;DR: Treatment with maslinic acid results in a significant inhibition of cell proliferation in a dose-dependent manner and causes apoptotic death in colon-cancer cells, suggesting the potential to provide significant natural defence against colon- cancer.

TL;DR: It is suggested that glioblastoma stem like cells were existed in CD133+ cells in U251 cell line with characteristics of self-renew and generation of an unlimited progeny of non-tumorigenic cells.

TL;DR: The growth-inhibitory effects of the astaxanthin-rich Haematococcus pluvialis were studied in HCT-116 colon cancer cells and it is suggested that H. pluvials may protect from colon cancer.

TL;DR: Improved understanding of the pathogenesis of H. pylori-associated gastric cancer may improve risk stratification for prevention and therapy.