Showing papers in "Cancer Letters in 2017"

TL;DR: The development of rational drug combinations that can simultaneously target tumor cells and the microenvironment may represent a solution to overcome therapeutic resistance.

TL;DR: This review considers the role of ROS in the various stages of cancer development and provides evidence that nutraceuticals derived from Mother Nature are highly effective in eliminating cancer cells.

TL;DR: The findings suggest that circPVT1 is a novel proliferative factor and prognostic marker in GC and may promote cell proliferation by acting as a sponge for members of the miR-125 family.

TL;DR: It is demonstrated for the first time that circRNA-MYLK might function as competing endogenous RNA (ceRNA) for miR-29a, which could contribute to EMT and the development of BC through activating VEGFA/VEGFR2 and downstream Ras/ERK signaling pathway.

TL;DR: The cancer patterns showed differences not only between male and female, but also among different geographic regions in China, and the age-standardized incidence rates were stable during the past decades in male, but significantly increased in female.

TL;DR: Exosomal miR signature is superior to exosomal GPC1 or plasma CA 19-9 levels in establishing a diagnosis of PDAC and differentiating betweenPDAC and CP.

TL;DR: A brief review of the crucial roles of FA metabolism in cancer development, and place emphasis on FA origin, utilization and storage in cancer cells is provided.

TL;DR: The current understanding of the anticancer effects of bee venom and MEL on different kinds of cancers is summarized and the available information for the possible mechanism of action of bee snake venom and/or MEL is presented.

TL;DR: In this review, the development and limitations of anti-PD-1/PD-L1 monotherapy in pancreatic cancer are discussed, the underlying mechanism is considered, combination strategies overcoming resistance to anti- PD-1 /PD- L1 immunotherapy, and the prospect of targeting PD- 1/PD/L1 for the immunotherapy of pancreatic cancers is considered.

TL;DR: Data suggest that CAF-mediated HCC tumour progression is partially related to the loss of antitumour miR-320a in the exosomes of CAFs and that promoting the transfer of stromal cell-derived miR -320a might be a potential treatment option to overcome HCC progression.

TL;DR: The commonly used isolation techniques for cancer stem cells in osteosarcoma as well as the identified biochemical and molecular markers are discussed.

TL;DR: The latest development on the discovery of a fourth-generation EGFR TKI, EAI045, appears to be an ideal target for overcoming the acquired resistance to the third-generation inhibitors.

TL;DR: The role of LncRNA SPRY4-IT1 as a miRNA sponge in bladder cancer is elucidates, new light is shed on Lnc RNA-directed diagnostics and therapeutics in bladder cancers is shed, and new light on LNCRNA-directed diagnostic and therapeutic activities is shed.

TL;DR: The radiomics study identified optimal machine-learning methods for the radiomics-based prediction of local failure and distant failure in advanced NPC, which could enhance the applications of radiomics in precision oncology and clinical practice.

TL;DR: An in-depth study of circRNAs will provide a better understanding of carcinogenesis and assist in developing clinical diagnostic and therapeutic strategies.

TL;DR: The identification of a new circRNA whose expression was lower in ccRCCs than adjacent normal tissues suggested that circHIAT1 functioned as a metastatic inhibitor to suppress AR-enhancedccRCC cell migration and invasion.

TL;DR: This study shows that tumor acidity exerts a selective pressure leading to the release of extracellular vesicles that express both PSA and exosome markers, and suggests that microenvironmental acidity may represent a key factor which determines qualitatively and quantitatively the release.

TL;DR: Over-expression of the lncRNA DANCR increased osteosarcoma cell proliferation, migration, and invasion in vitro, as well as promoted xenograft tumor growth and lung metastasis in vivo.

TL;DR: Global and detailed analyses were both conducted on relevant high-throughput sequencing data and possible interventions against m6A demethylases are also explored in this review, which may be advantageous for the treatment of m 6A related cancers.

TL;DR: The results indicate that the HOTTIP/WDR5/HOXA9/Wnt axis contributes to PCSC stemness and is a potential therapeutic target for PDAC.

TL;DR: MALAT1 can promote tumorigenicity and metastasis in GC by facilitating VM and angiogenesis via the VE-cadherin/β-catenin complex and ERK/MMP and FAK/paxillin signaling pathways.

TL;DR: It is concluded that the lncRNA FoxC2-AS1 may promote doxorubicin resistance in OS by increasing the expression of transcription factor FOXC2, further facilitating ABCB1 expression.

TL;DR: Through inhibition of LDHA, miR-30a-5p dampens glycolysis by decreasing glucose uptake, lactate production, ATP generation, and extracellular acidification rate (ECAR), and increasing oxygen consumption rate (OCR) in breast cancer cells.

TL;DR: P prognostic predictors based on alternative splicing events with high performances for risk stratification in NSCLC patients are created and interesting splicing networks in LUAD and LUSC are uncovered which could be underlying mechanisms.

TL;DR: Recent findings on the role of SR and hnRNP proteins in apoptotic control in cancer cells as well as their significance in anticancer treatments are discussed.

TL;DR: Manumycin-A (MA), a natural microbial metabolite, was identified as an inhibitor of exosome biogenesis and secretion by castration-resistant prostate cancer (CRPC) C4-2B, but not the normal RWPE-1, cells.

TL;DR: Together, this survey substantiates the concept that DNA hypomethylation promotes tumorigenesis via transcriptional activation of oncogenes and indicates that cancer-germline genes may represent valuable targets for the development of anti-cancer therapies with limited side effects.

TL;DR: Exosomal formulation of Anthos enhanced antiproliferative and anti-inflammatory effects compared with the free Anthos against various cancer cells in vitro and can be developed as a non-toxic, widely applicable therapeutic agent.

TL;DR: The state of current and emerging anti-stromal targeted therapies are summarized, with major emphasis on the role of miRNAs in PDAC stroma and their potential use as novel therapeutic agents to modulate PDAC tumor-stromAl interactions.

TL;DR: An extracellular pro-tumorigenic role for tumor-derived, exosome-associated miR-939 is indentify that can explain its association with worse prognosis in TNBCs.