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JournalISSN: 1875-9777

Cell Stem Cell

About: Cell Stem Cell is an academic journal. The journal publishes majorly in the area(s): Stem cell & Induced pluripotent stem cell. It has an ISSN identifier of 1875-9777. Over the lifetime, 2789 publication(s) have been published receiving 333258 citation(s). more


Open accessJournal ArticleDOI: 10.1016/J.STEM.2007.08.014
15 Nov 2007-Cell Stem Cell
Abstract: Application of stem cell biology to breast cancer research has been limited by the lack of simple methods for identification and isolation of normal and malignant stem cells. Utilizing in vitro and in vivo experimental systems, we show that normal and cancer human mammary epithelial cells with increased aldehyde dehydrogenase activity (ALDH) have stem/progenitor properties. These cells contain the subpopulation of normal breast epithelium with the broadest lineage differentiation potential and greatest growth capacity in a xenotransplant model. In breast carcinomas, high ALDH activity identifies the tumorigenic cell fraction, capable of self-renewal and of generating tumors that recapitulate the heterogeneity of the parental tumor. In a series of 577 breast carcinomas, expression of ALDH1 detected by immunostaining correlated with poor prognosis. These findings offer an important new tool for the study of normal and malignant breast stem cells and facilitate the clinical application of stem cell concepts. more

Topics: Cancer stem cell (68%), Stem cell (64%), Adult stem cell (62%) more

3,506 Citations

Open accessJournal ArticleDOI: 10.1016/J.STEM.2008.07.003
Mihaela Crisan1, Solomon Yap2, Louis Casteilla2, Louis Casteilla3  +18 moreInstitutions (5)
11 Sep 2008-Cell Stem Cell
Abstract: Mesenchymal stem cells (MSCs), the archetypal multipotent progenitor cells derived in cultures of developed organs, are of unknown identity and native distribution. We have prospectively identified perivascular cells, principally pericytes, in multiple human organs including skeletal muscle, pancreas, adipose tissue, and placenta, on CD146, NG2, and PDGF-Rbeta expression and absence of hematopoietic, endothelial, and myogenic cell markers. Perivascular cells purified from skeletal muscle or nonmuscle tissues were myogenic in culture and in vivo. Irrespective of their tissue origin, long-term cultured perivascular cells retained myogenicity; exhibited at the clonal level osteogenic, chondrogenic, and adipogenic potentials; expressed MSC markers; and migrated in a culture model of chemotaxis. Expression of MSC markers was also detected at the surface of native, noncultured perivascular cells. Thus, blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells. more

3,378 Citations

Open accessJournal ArticleDOI: 10.1016/J.STEM.2007.06.002
13 Sep 2007-Cell Stem Cell
Abstract: Summary Pancreatic adenocarcinoma is currently the fourth leading cause for cancer-related mortality. Stem cells have been implicated in pancreatic tumor growth, but the specific role of these cancer stem cells in tumor biology, including metastasis, is still uncertain. We found that human pancreatic cancer tissue contains cancer stem cells defined by CD133 expression that are exclusively tumorigenic and highly resistant to standard chemotherapy. In the invasive front of pancreatic tumors, a distinct subpopulation of CD133 + CXCR4 + cancer stem cells was identified that determines the metastatic phenotype of the individual tumor. Depletion of the cancer stem cell pool for these migrating cancer stem cells virtually abrogated the metastatic phenotype of pancreatic tumors without affecting their tumorigenic potential. In conclusion, we demonstrate that a subpopulation of migrating CD133 + CXCR4 + cancer stem cells is essential for tumor metastasis. Strategies aimed at modulating the SDF-1/CXCR4 axis may have important clinical applications to inhibit metastasis of cancer stem cells. more

Topics: Cancer stem cell (77%), CA19-9 (65%), Pancreatic cancer (65%) more

2,535 Citations

Open accessJournal ArticleDOI: 10.1016/J.STEM.2010.08.012
Luigi Warren1, Philip D. Manos1, Philip D. Manos2, Tim Ahfeldt3  +19 moreInstitutions (7)
05 Nov 2010-Cell Stem Cell
Abstract: SUMMARY Clinical application of induced pluripotent stem cells (iPSCs) is limited by the low efficiency of iPSC derivation and the fact that most protocols modify the genome to effect cellular reprogramming. Moreover, safe and effective means of directing the fate of patient-specific iPSCs toward clinically useful cell types are lacking. Here we describe a simple, nonintegrating strategy for reprogramming cell fate based on administration of synthetic mRNA modified to overcome innate antiviral responses. We show that this approach can reprogram multiple human cell types to pluripotency with efficiencies that greatly surpass established protocols. We further show that the same technology can be used to efficiently direct the differentiation of RNA-induced pluripotent stem cells (RiPSCs) into terminally differentiated myogenic cells. This technology represents a safe, efficient strategy for somatic cell reprogramming and directing cell fate that has broad applicability for basic research, disease modeling, and regenerative medicine. more

Topics: Directed differentiation (62%), Reprogramming (61%), Cell potency (60%) more

2,466 Citations

Open accessJournal ArticleDOI: 10.1016/J.STEM.2009.05.005
Dohoon Kim1, Chun-Hyung Kim1, Jung-Il Moon1, Young-Gie Chung  +7 moreInstitutions (1)
05 Jun 2009-Cell Stem Cell
Abstract: Document S1. Supplemental Experimental Procedures, Supplemental References, Eight Figures, and Four TablesxDownload (.47 MB ) Document S1. Supplemental Experimental Procedures, Supplemental References, Eight Figures, and Four Tables more

1,834 Citations

No. of papers from the Journal in previous years

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Journal's top 5 most impactful authors

Rudolf Jaenisch

25 papers, 6.3K citations

George Q. Daley

21 papers, 5.9K citations

Alexander Meissner

14 papers, 5K citations

Nissim Benvenisty

13 papers, 1.9K citations

Magdalena Götz

12 papers, 1.6K citations

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