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JournalISSN: 0092-8674


About: Cell is an academic journal. The journal publishes majorly in the area(s): Gene & RNA. It has an ISSN identifier of 0092-8674. Over the lifetime, 22221 publication(s) have been published receiving 7025294 citation(s). more

Topics: Gene, RNA, DNA more

Open accessJournal ArticleDOI: 10.1016/J.CELL.2011.02.013
Douglas Hanahan1, Robert A. Weinberg2Institutions (2)
04 Mar 2011-Cell
Abstract: The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list-reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the "tumor microenvironment." Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer. more

42,275 Citations

Open accessJournal ArticleDOI: 10.1016/S0092-8674(04)00045-5
David P. Bartel1Institutions (1)
23 Jan 2004-Cell
Abstract: MicroRNAs (miRNAs) are endogenous ∼22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes. more

Topics: MicroRNA 34a (63%), Lin-4 microRNA precursor (56%), MicroRNA sequencing (55%) more

30,422 Citations

Open accessJournal ArticleDOI: 10.1016/S0092-8674(00)81683-9
Douglas Hanahan1, Robert A. Weinberg2Institutions (2)
07 Jan 2000-Cell
Abstract: We wish to thank Terry Schoop of Biomed Arts Associates, San Francisco, for preparation of the figures, Cori Bargmann and Zena Werb for insightful comments on the manuscript, and Normita Santore for editorial assistance. In addition, we are indebted to Joe Harford and Richard Klausner, who allowed us to adapt and expand their depiction of the cell signaling network, and we appreciate suggestions on signaling pathways from Randy Watnick, Brian Elenbas, Bill Lundberg, Dave Morgan, and Henry Bourne. R. A. W. is a Ludwig Foundation and American Cancer Society Professor of Biology. His work has been supported by the Department of the Army and the National Institutes of Health. D. H. acknowledges the support and encouragement of the National Cancer Institute. Editorial policy has rendered the citations illustrative but not comprehensive. more

26,950 Citations

Open accessJournal ArticleDOI: 10.1016/J.CELL.2006.07.024
Kazutoshi Takahashi1, Shinya Yamanaka1Institutions (1)
25 Aug 2006-Cell
Abstract: Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions. Unexpectedly, Nanog was dispensable. These cells, which we designated iPS (induced pluripotent stem) cells, exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Subcutaneous transplantation of iPS cells into nude mice resulted in tumors containing a variety of tissues from all three germ layers. Following injection into blastocysts, iPS cells contributed to mouse embryonic development. These data demonstrate that pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors. more

Topics: KOSR (74%), Induced pluripotent stem cell (72%), Stem cell (70%) more

21,746 Citations

Open accessJournal ArticleDOI: 10.1016/J.CELL.2007.11.019
Kazutoshi Takahashi1, Koji Tanabe1, Mari Ohnuki1, Megumi Narita1  +3 moreInstitutions (1)
30 Nov 2007-Cell
Abstract: SUMMARY Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from mouse somatic cells by transduction of four defined transcription factors. Here, we demonstrate the generationofiPS cells from adult human dermal fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc. Human iPS cells were similar to human embryonic stem (ES) cells in morphology, proliferation, surface antigens, gene expression, epigenetic status of pluripotent cell-specific genes, and telomerase activity. Furthermore, these cells could differentiate into cell types of the three germ layers in vitro and in teratomas. These findings demonstrate that iPS cells can be generated from adult human fibroblasts. more

Topics: Induced pluripotent stem cell (72%), Embryonic stem cell (71%), Stem cell (70%) more

16,624 Citations

No. of papers from the Journal in previous years

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Journal's top 5 most impactful authors

David Baltimore

62 papers, 30.3K citations

Richard Axel

41 papers, 21.3K citations

Tom Maniatis

40 papers, 13.4K citations

Rudolf Jaenisch

34 papers, 30.1K citations

Joan Massagué

31 papers, 25.4K citations

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