Showing papers in "Cellular Immunology in 2011"

TL;DR: The results indicate that human Wharton's jelly cells have low immunogenicity, and conclude that the immunomodulatory effect of WJCs may be related to direct cell contact and inhibition of cytokine secretion by human peripheral blood lymphocytes.

TL;DR: It is suggested that MSC source could be of importance while designing immunomodulating cell therapy in transplantation because of its importance in the control of inflammation and TLR ligation.

TL;DR: The data collectively conclude that resident ASCs in breast cancer tissue may have crucial roles in breast tumor growth and progression by inducing regulatory molecules and promoting anti-inflammatory reaction within the tumor microenvironment.

TL;DR: It is determined that a CD14(+)CD16(+) CD11b(+)Mac387(+) Mo/Mac subpopulation preferentially transmigrates across the authors' in vitro BBB model in response to CCL2.

TL;DR: Detailed analyzes of the number of stressful events that affected the patients in addition to their cancer diagnosis revealed that this type of stress measure correlated with elevated levels of MDSC, indicating the existence of a complex relationship between stress and immune function in breast cancer patients.

TL;DR: It is proposed that besides its chemoattractant function CCL5 has a modulatory effect on activated microglia.

TL;DR: It is found that the induction of IL-17-producing CD4(+) T cells was significantly increased in aged individuals compared with young healthy ones and may contribute to the increased development of inflammatory disorders in the elderly.

TL;DR: Supragingival and subgingival biofilms differentially regulate the gene expressions of NLRP3 and AIM2 inflammasomes and their down-stream IL-1 targets, which corroborates the dampening of host immune responses, in favour of pathogen survival and persistence.

TL;DR: The T. crassiceps-induced immune regulation decreased EAE severity by dampening T cell activation, proliferation and migration to the CNS, which was associated with both decreased MOG-specific splenocyte proliferation and IL-17 production and limited leukocyte infiltration into the spinal cord.

TL;DR: The results suggested that APS possess potent immunomodulatory activity by stimulating macrophage and could be used as an immunotherapeutic adjuvant.

TL;DR: TQ supplementation of GD mothers with the natural antioxidant TQ during pregnancy and lactation periods improves diabetic complications and maintains an efficient T cell immune response in their offspring, providing a protective effect in later life.

TL;DR: There is strong evidence that atorvastatin can act as an inhibitor in EAN by inhibiting the immune response of Th1 and Th17, decreasing the expression of co-stimulatory molecule, and up-regulating the number of T regulatory cells.

TL;DR: It is demonstrated that ligation of TLR2, but not TLR4, could significantly inhibit migration of MSC, impair M SC-mediated immunosuppression on allo-MLR, and reduce MSC-mediated expansion of CD4+CD25+Foxp3+ regulatory T cells.

TL;DR: The role of decoy therapy is emphasized in understanding the crucial influence of this transcription factor, and not only the efficacy of this therapeutic approach but also its necessity and contraindications are weighed.

TL;DR: In this paper, the authors identify mimicry epitopes that bear sequences similar to those in cardiac myosin heavy chain (myHC)-α 334-352 and demonstrate that the mimics induce cross-reactive T cell responses for MYHC-α 334 -352 as verified by MHC class II IA k /tetramer staining and Th-1 and Th 17 cytokines similar with those of myHCα 334 −352.

TL;DR: Results collectively show that polyphenols derived from CA boost T cell immunity by increasing the number of T cells and its sensitivity towards stimulants and decreasing ROS production by neutrophils that could potentially harm multiple biological systems in aged individuals.

TL;DR: Compared two MSC populations, human adipose derived stem cells and human amniotic mesenchymal stromal cells, and RTECs regarding their potential to inhibit monocyte-derived dendritic cell (DC) differentiation and maturation in indirect co-culture, it is found that inhibition of DC generation by MSCs andRTECs might be mediated by different soluble factors.

TL;DR: The results demonstrated that a significant decrease in the level of IL-4 in the animals treated with DHA and significant decreased in thelevel of splenic CD4(+)CD25(+) Foxp3(+) T regulatory cells.

TL;DR: Murine dendritic cells prepared from bone marrow precursors were prepared and vitamin C taken up into DCs increased IL-12p70 secretion of these cells by modulating the activation of signal molecules, and thus shifted immune responses toward Th1.

TL;DR: It is shown that purified extracellular domain of BST2 protein specifically and significantly decreased the adhesion of human monocytes to HUVECs, which suggests that IFN-γ-induced BST2 expression may be involved in monocyte migration from blood through the endothelium to the inflammation site.

TL;DR: It is demonstrated that established breast tumor cell lines produce IL-12p40 monomer/homodimer, but not IL- 12p70, which may inhibit substantially the anti-tumor immune response.

TL;DR: Evidence that galectins distinctively modulate central monocyte/macrophage function is provided by inhibiting T-cell function via macrophage priming and is shown to link the innate and adaptive immune systems and provide new insights into the action of sugar-binding proteins.

TL;DR: During chronic HCV infection non-reactive HCV-specific CD8(+) cells targeting the virus are PD-1(+)/CD127(-)/Bim(+) and, blocking apoptosis andPD-1/PD-L1 pathway on them enhances in vitro reactivity.

TL;DR: The results showed that Tregs in recipients are helpful to maintain a stable graft function, reduce acute/chronic rejection rate and the T Regs in graft and urine, rather than in PBL, may have a better diagnostic value for transplant outcomes.

TL;DR: Data demonstrate that treatment with amolimogene elicits T cell responses to HPV 16, 18, 6 and 11, and T cells primed and expanded in vitro with an HPV 18 peptide demonstrated cross-reactivity to the corresponding HPV 11 peptide.

TL;DR: Suppression of VPAC1 signals in VPAC2-KO mice by PKA inhibitors reduced the clinical and histological severity of DSS-induced colitis, as well as tissue levels of IL-6, IL-1β and MMP-9, thus VIP enhancement of the severity ofDSS- induced colitis is mediated solely byVPAC1 receptors.

TL;DR: The aim of this study was to delineate the temporal and spatial sequence of STAT1 and STAT3 activation during development of GVHD following fully Major Histocompatibility Complex-mismatched allogeneic Bone Marrow Transplantation (BMT).

TL;DR: Findings indicate cytokines induced by MyD88-dependent and -independent signaling cascades regulate cathepsin activities during macrophage responses to TLR stimulation.

TL;DR: Interaction of GP2 with SREC-I and uptake might have profound effects in antigen clearance and mediation of the immune response and other presently unknown receptors for GP2 on DCs might be involved in this process.

TL;DR: CD39(+) cells could have a balancing regulatory role in the inflammatory process observed in patients with T2D, and their correlation with the concentration of HbA1c in blood was significant.