Showing papers in "Československá patologie in 1981"

Multiple carcinomas arising from congenital cysts of the liver and kidneys

Abstract: In a 48 year old man suffering from dyspepsia and progressive enlargement of the liver, the clinical suspicion of a malignant cystic disease of the liver was voiced. Six months after the onset of the complaints the disease was diagnosed through a biopsy performed during an operative laporotomy. The patient died in spite of combined antitumorous chemotherapy in some further 7 months in a state of hepatic coma. A detailed pathologico-anatomical examination divulged the picture of a very rare form of carcinoma arising from the membrane covering not only the hepatic cysts but also those in the kidneys. Microscopically it had the structure of a papillary adenocarcinoma. Differential diagnostic variations of this tumour as compared to true neoplastic cysts i. e. cystadenomas or cystadenocarcinomas arising from the lining of hepatic bile ducts, are pointed out in this paper.

[Morphogenesis of Gaucher's cells and cells similar to them (in myelosis)].

Abstract: The cytohistological resemblance between Gaucher's cells and similar cells of the bone marrow in cases of myelosis is great but their electronoptical pictures vary,. In Gaucher's cells there are membranous limited and non-limited corpuscles, composed of typical convoluted tubules, which do not contain lipids, they may be found even in the cisterns of the rough endoplasmatic reticulum and in perinuclear cisterns. They probably represent the proteinic bearer of glucosyl-ceramids, which are extracted during standard histological techniques and therefore do not form part of the histological picture. The gradual loss of the membraneceous lining around these corpuscles is probably the expression of differently advanced states of lysosomatic break down. The Gaucherlike cells of the bone marrow are apparently macrophages with many cytolysosomes, the tubular portions of which are usually not membranous limited, do not have any tendency of screwing and they differ from the previous ones in many other details.

Electron microscopic classification of pulmonary carcinoma

Abstract: In a selected group of 175 pulmonary carcinomas the authors demonstrated how electron microscopy renders it possible to respect in their classification more systematically cytological differentiation than when the revised version of the "Histological typisation of pulmonary tumours" published by WHO is used. After electron microscopic examination the group of so-called large cell carcinomas was divided into carcinomas with varying differentiation (small-cell from endocrine cells, pavement cells from keratinocytes, glandular from exocrine cells) and non-differentiated ones (from primitive cells). To the non-differentiated carcinomas those originally small-cell carcinomas were added which lacked ultrastructural differentiation. The uniform subtle structure of glandular carcinomas, however, did not support the importance of differentiation of their subgroups. It became particularly doubtful to have as a separate unit bronchioloalveolar carcinomas when in the group only two bronchiolar carcinomas (from Clara cells) were detected and no carcinoma from alveolar epithelium (from granular pneumonocytes). Double ultrastructural differentiation was found in 10-15% of the carcinomas; their group classification respected the predominating differentiation.

[Hepatoma after long-term administration of griseofulvin].

Abstract: After the 12- and 14-month administration of the preparation gricin to ten white and two bare (nunu) mice in hepatic tissue in addition to diffuse and nodular hyperplasia hepatomas developed The ultrastructural changes of tumour cells were not typical and involved above all GER, nuclei and nucleoli They corresponded to findings of experimental carcinogenesis and human hepatomas

Morphological typing of respiratory tract tumors

Abstract: A group of 224 tumours of the respiratory tract was used to present experience with the standard histological classification, as proposed by WHO--incl. the revised version of pulmonary tumour classification which is under preparation. Electron microscopic facts from the authors' own material as well as from recent literature served in particular as a stimulus for the critical evaluation of some details of the standard classification. It served also as the basis for recommendations for rational modifications for its use in particular in Czech and Slovak speaking areas: 1. Prefer in respiratory pathways the term papilloma from respiratory epithelium to "transient" papilloma and not differentiate exophytic and inverted forms. 2. Respect the differentiation of bronchial adenomas and carcinoids, but identify atypical carcinoids with small-cell (oat-cell) carcinomas. 3. As to other carcinomas of the respiratory pathways to differentiate only between squamous carcinomas (spindle-cell and verrucal), glandular (in addition to adenoid cystic and mucoepidermoid) and undifferentiated. 4. In the section of pulmonary carcinomas to abandon completely large-cell carcinomas and to describe tumours which cannot be included in other groups as undifferentiated carcinomas. 5. Avoid in the other respect satisfactory classification pattern of pulmonary carcinomas subvariants (in particular in the group of glandular carcinomas) and include exceptional units in the group "others". 6. Arrange the group of malignant lymphomas according to the extrapulmonary classification pattern and include there from the group of tumourous lesions so-called lymphoproliferative processes, eosinophil granuloma and gangrenescent granuloma. 7. Use consistent with the nomenclature in the sphere of the nervous system the term olfactory neuroblastoma and omit its rare sub-variants.