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JournalISSN: 1210-7875

Československá patologie 

Elsevier BV
About: Československá patologie is an academic journal published by Elsevier BV. The journal publishes majorly in the area(s): Carcinoma & Medicine. It has an ISSN identifier of 1210-7875. Over the lifetime, 597 publications have been published receiving 2660 citations. The journal is also known as: Czecho-Slovak Pathology and Forensic Medicine & Czech-Slovak Pathology.


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Journal Article
TL;DR: The Association for European Cardiovascular Pathology developed guidelines, which represent the minimum standard that is required in the routine autopsy practice for the adequate assessment of sudden cardiac death, including not only a protocol for heart examination and histological sampling, but also for toxicology and molecular investigation as discussed by the authors.
Abstract: Although sudden cardiac death is one of the most important mode of death in Western Countries, pathologists and public health physicians have not given this problem the attention it deserves. New methods of preventing potentially fatal arrhythmias have been developed, and the accurate diagnosis of the causes of sudden cardiac death is now of particular importance. Pathologists are responsible for determining the precise cause of sudden death but there is considerable variation in the way in which they approach this increasingly complex task. The Association for European Cardiovascular Pathology developed guidelines, which represent the minimum standard that is required in the routine autopsy practice for the adequate assessment of sudden cardiac death, including not only a protocol for heart examination and histological sampling, but also for toxicology and molecular investigation. Our recommendations apply to university medical centres, regional and district hospitals and all types of forensic medicine institutes. If a uniform method of investigation is adopted throughout the European Union, this will lead to improvements in standards of practice, allow meaningful comparisons between different communities and regions and, most importantly, permit future trends in the patterns of disease causing sudden death to be monitored.

317 citations

Journal Article
TL;DR: The rapidly increasing knowledge of the genetics of mesenchymal tumours allows us to make more accurate diagnoses as well as to better understand of the pathogenesis of these lesions, but abundant molecular and cytogenetic data highlight an increasing problem of growing numbers of genetic overlaps even among quite different tumours.
Abstract: In early 2013, the new classification of tumours of soft tissue and bones was released. This edition belongs to the fourth series of so-called Blue Books published under the auspices of the World Health Organisation (WHO). The current classification follows the previous third edition, from which it differs in several aspects. The vast majority of changes are related to the soft tissue tumour section, which was enriched with three new chapters, some entities or terms were removed, new diagnoses were introduced, and several tumours were reallocated to other categories. Albeit to a lesser extent, similar changes have occurred also in the classification of bone tumours. Compared to the previous edition, more detailed molecular and cytogenetic data were incorporated in the current issue. The rapidly increasing knowledge of the genetics of mesenchymal tumours allows us to make more accurate diagnoses as well as to better understand of the pathogenesis of these lesions. However, abundant molecular and cytogenetic data highlight an increasing problem of growing numbers of genetic overlaps even among quite different tumours. The coexistence of several grading systems of soft tissue tumours is another controversial issue mentioned in the recent WHO classification. The main advantages and limitations of the two most widely used grading systems are also discussed.

85 citations

Journal Article
TL;DR: Five cases of the diffuse sclerosing variant of papillary thyroid carcinoma (DSPC) were presented and the fifth case was discovered in a statistically not defined series of carcinomas of the thyroid gland.
Abstract: Five cases of the diffuse sclerosing variant of papillary thyroid carcinoma (DSPC) were presented. The fifth case was discovered in a statistically not defined series of carcinomas of the thyroid gland. DSPC were found in 5.7% of 70 cases of thyroid papillary carcinoma. All the cases described showed a similar histological picture. In the first case a "dominant nodule" was found. Immunohistologically B-cell markers were mostly proved on lymphocytes of the focal lymphocytic infiltration. Accumulation of Langerhans cells was present in the tumour foci. The finding of these cells is regarded as a sign of an enhanced immunological defense mechanism. The clinical follow-up interval of patients was 3 to 9 years. Less favourable prognosis of DSPC as compared with classical papillary carcinomas could not be confirmed in this series.

69 citations

Journal Article
TL;DR: Over a five year period 50 malignant tumours has been histologically proved in a group of 1378 patients who underwent fine needle aspiration biopsy of thyroid, five of these were medullary carcinomas.
Abstract: Over a five year period 50 malignant tumours (3.8% of investigations) has been histologically proved in a group of 1378 patients who underwent fine needle aspiration biopsy of thyroid. Five of these were medullary carcinomas (0.38% of investigation, 10% of malignancies). During revision and cytohistological correlation the most important cytologic diagnostic features for the sequential diagnosis of medullary carcinoma especially in cases without indicative clinical symptomatology have been checked. The following proved to be indicative especially if coinciding: a) background formed by blood with minimum or no colloid; b) clusters of epithelial cells with poor cohesion, sometimes multilayered, microfollicular, or stroma-like fusiform cells; c) striking anisocytosis, polygonal, plasmacytoid, fusiform, polyploid, and binucleated cells and naked nuclei in the background; d) striking anisokaryosis, at least part of the nuclei ovoid or elongated, chromatin rough, giant nuclei; e) amyloid identifiable in some tissue micro-fragments. If additional smears or cyto-block material are available it may be possible to establish the diagnosis at the cytology level using amyloid staining, argyrophilia test or immunohistochemistry. However if there is any cytological suspicion of medullary carcinoma, serum calcitonin should be investigated to confirm the preoperative diagnosis of medullary carcinoma enabling the patient to undergo one-step radical surgery.

56 citations

Journal Article
TL;DR: The main pathogenetic factor in NBTE seems to be a state of hypercoagulation, with carcinomas of the ovaries, biliary system, pancreas, lung, and stomach being most frequently affected.
Abstract: A descriptive term nonbacterial thrombotic endocarditis (NBTE) is used currently instead of the former name marantic endocarditis. The study describes 171 cases of NBTE encountered in autopsies over a period of 22 years (an incidence of 0.93% in adults). Malignancy was present in 59% of cases. Tumors relatively most frequently associated with NBTE were carcinomas of the ovaries, biliary system, pancreas, lung, and stomach. The vegetations were located mostly on the left-sided valves (mitral 64%, aortic 24%, both 9%). The involved valves were otherwise normal in 82%, and they were previously damaged in 18%. Systemic emboli from valvular vegetations occurred in 41% of patients, with splenic, cerebral, and renal circulations being most frequently affected. Pulmonary embolism was noted in 43%. The state of nutrition at autopsy was within normal limits in 35%; there was undernourishment or cachexia in 40%, and overweight or obesity in 22% of patients. The main pathogenetic factor in NBTE seems to be a state of hypercoagulation.

47 citations

Performance
Metrics
No. of papers from the Journal in previous years
YearPapers
202311
202222
20211
20204
20197
20186