Showing papers in "Chemico-Biological Interactions in 1979"

TL;DR: A highly anionic protein which is not present in control oysters was found to be present in cadmium-exposed animals after 3 days of treatment and to increase in concentration at succeeding time points.

TL;DR: Nitrosobenzene (NOB) formed acid labile conjugates with reduced glutathione (GSH) and hemoglobin within red cells and intermediate formation of NOB and thiol radicals was ruled out by analysis of the equilibrium data.

TL;DR: In vitro incubation of the chemically activated free radical intermediates with DNA resulted in covalent binding of these drugs to DNA, which may account for more severe DNA damage induced by this drug.

TL;DR: GSH S-transferase activity was also found in liver or hepatopancreas of every aquatic species studied and in a number of extrahepatic organs, when 1,2-dichloro-4-nitrobenzene or 1-chloro-2,4-dinitrobenZene served as substrate.

TL;DR: The results indicate that chromate and not chromic compounds may be the carcinogenic form for man and illustrate the utility of the DNA repair technique to study the effects on human cells of inorganic carcinogens and mutagens.

TL;DR: Parthenin, the major sesquiterpene lactone of Parthenium hysterophorus, a weed responsible for dermatitis in man is primarily restricted to leaf and stem trichomes.

TL;DR: The results are in good agreement with previous experiments which indicate that both DEC and DBE are activated through conjugation with glutathione (GSH), and one possible metabolic endproduct of a GSH conjugate is the corresponding mercapturic acid.

TL;DR: Ellipticine and its 9-hydroxy derivative inhibit strongly various liver monooxygenase activities mediated by microsomes from control and phenobarbital, benzo[alpha]pyrene (BP) or Aroclor 1254 (AroClor)-pretreated rats.

TL;DR: A fairly good correlation holds between the in vitro and in vivo (antitumor effect) assays, offering a possible prescreening test for a cheaper and rapid evaluation of chemotherapeutic activity of these compounds.

TL;DR: It is proposed that the rate of degradation and hence the turnover of the protein is influenced by the ratio of Cd2+ to other bound cations (e.g. Zn2+ and Cu2+).

TL;DR: In two strains of murine lymphoma L5178Y cross-sensitive to X-rays and UV light, a close resemblance was found between dose-survival relationships after cis-PAD andUV light treatment, respectively.

TL;DR: Findings indicate that in contrast to paracetamol hepatoxicity, that nephrotoxicity of p-aminophenol is dependent upon oxidation to a toxic metabolite by some other pathway and a similar metabolite may be responsible for the neph rotoxic action of phenacetin.

TL;DR: P-Aminophenol administration lowered the microsomal cytochrome P-450 and b5 content and decreased the activity of NADPH cy tochrome c reductase in kidney, but not in liver.

TL;DR: The accumulation of Cd and Pb in the gills of the lamellibranch mollusc Mytilus edulis has been studied by electron microscopy, X-ray microanalysis, atomic absorption spectroscopy and radionuclide monitoring.

TL;DR: It is concluded that E. coli WP2 uvrA, deficient in excision endonuclease activity, may be inactivated by a very small number of cross-links, probably one and that the inactivating lesion is probably a single mono-adduct.

TL;DR: The data suggest that the N-acetoxy-N-arylacetamides are generally useful models for ultimate metabolites derived in vivo, even if the in vivo metabolites do not carry an acetyl group.

TL;DR: Consideration of the known chemistry of dioxolanes, together with recent advances in the understanding of double Soret spectra, lead to a possible explanation for the differences between the spectra of doxolanes and their aromatic analogs, the methylenedioxyphenyl compounds.

TL;DR: The previously reported reaction at N2- and N7- of guanine following addition of 7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) to an aqueous solution of DNA has been studied in more detail.

TL;DR: Characterisation of the major AFG1-DNA adduct showed it to have the structure trans-9,10-dihydro-9-(7-guanyl)-10-hydroxy-aflatoxin G1, similar to that obtained from AFB1 by activation in vivo, in vitro and after peracid oxidation.

TL;DR: The results show that the formation of different reactive benzo[ a ]pyrene intermediates which bind covalently to DNA is very similar between 3-MC-treated rat and untreated trout liver microsomes.

TL;DR: Methylmercury, after incubation at 3k7 degrees C and pH 7.0 with selenite in the presence of rat erythrocytes, can be extracted into benzene as an unstable 2 : 1 complex withSelenium.

TL;DR: There is an age-related difference in response of epoxide metabolizing enzymes to polychlorinated biphenyl treatments between rats and mice.

TL;DR: Results, in conjunction with metabolic studies, indicate that nitrosamines are denitrosated by a reductive process in which cyt.

TL;DR: This is the first report of 14C-labeled PCB being bound to purified RNA, DNA, and proteins isolated from the tissues of animals treated in vivo and the binding is thought to be covalent and to be the result of metabolic activation.

TL;DR: Chromate compounds induced sister chromatoid exchanges (SCEs) and chromosome aberrations in cultured mammalian cells and in human fibroblasts exposed to the compounds K2Cr2O7 and K2 CrO4.

TL;DR: The more tumorigenic (-)-enantiomer is the predominant isomer of BA 3,4-dihydrodiol formed by liver microsomes from BA.

TL;DR: For the first time a hexachlorobiphenyl unchlorinated in the para position, 2,3,5,2',3',5'-HCB has been shown to be a specific inducer of cytochrome P-450 and chlorination at para (4,4') positions in chlorobipenyls is not necessarily required for biological activity.

TL;DR: The results suggest, also in the light of findings of other authors, the induction of different species of cytochrome P-450 in the nuclei and microsomes.