Showing papers in "Chemico-Biological Interactions in 1985"

TL;DR: The mutagenicity of the cysteine conjugate of HCBD is consistent with the known renal carcinogenicity of this chemical and the conjugates of TFE and HFP were not mutagenic either in the presence of rat kidney S9 and cofactors.

TL;DR: The methylation to DMA seems to be almost as important for the detoxication following exposure to arsenate as that following Exposure to arsenite.

TL;DR: The results suggest that quinone-induced oxidative challenge caused by the chemical interactions of a quin one and glutathione may have biological relevance.

TL;DR: Findings are related to the view that aldehydes, especially HNE, may act as diffusible cytotoxic compounds when lipid peroxidative derangement of membrane lipids is provoked by toxic conditions.

TL;DR: The formation of PBN-free radical adducts has also been observed in phenobarbital-induced rats in vivo when intoxicated with chloroform, bromoform or iodoform, suggesting that the reductive metabolism of trihalomethanes might be of relevance to their established toxicity in the whole animal.

TL;DR: T-BHQ was the most potent inhibitor of CL, lipid peroxidation and ODC activity and simultaneously reduced molecular oxygen, suggesting the possibility that O-2 may act as a precursor to the formation of free radicals which are reactive with t-B HQ and more directly involved in the process of tumor promotion.

TL;DR: A combination of ferroxidase and radical scavenging activities in fluids containing iron complexes and hydrogen peroxide, but no SOD or catalase, would make caeruloplasmin an important extracellular antioxidant.

TL;DR: Antibodies elicited against the haptens cis-Pt(NH3)2dGuodGMP and its ribo-analog, both covalently coupled to bovine serum albumin, recognize adducts of cis-diamminedichloroplatinum(II) (cis-DDP) in DNA.

TL;DR: The concentration of nickel that induced DNA-protein cross-linking correlated with those metal concentrations that reversibly inhibited cellular replication and thus induced single strand breaks and DNA protein cross-links.

TL;DR: The leukocytes appear to be a useful model cell for studying one electron oxidation-catalyzed carcinogen activation and higher concentrations of azide and cyanide prevented binding without affecting the respiratory burst indicating that myeloperoxidase is a catalyst for the binding.

TL;DR: Findings are consistent with the theories which indicate that lipid peroxidation requires the presence of Fe2+-ions, regardless of the initiating agent, and that LPO is involved in CCl4-toxicity, but most probably not in paracetamol-induced liver damage.

TL;DR: In neither the mouse nor the rat did 1-naphthol cause a depletion of non-protein sulphydryl levels or tissue damage in the liver, lung or kidney, and the toxicity of naphthalene does not appear to be mediated via 1-methanol.

TL;DR: It is reported that the in vitro induction of lipid peroxidation in human and rat blood with either UV irradiation or phenylhydrazine failed to increase the plasma levels of this isomer and casts doubts on its validity as a specific marker in humans.

TL;DR: Results indicate the Fundulus eleutheroembryos probably can activate BP to its ultimate carcinogenic form, the 7,8-dihydrodiol-9,10-epoxide, and induction of AHH activity by PCBs is likely to increase the rate of formation of activated metabolites from BP and related compounds.

TL;DR: There is a direct correlation between the Taft substituent constant sigma*, of various alkylsubstituents in 7-position and the respective acid dissociation constants and chemical stabilities of 7-alkylated guanosines.

TL;DR: A comparison of the degree of alkylation of plasma proteins, hemoglobin and guanine-N-7 in DNA suggests that the two compounds are about equally effective as alkylating agents in vivo at moderate dose levels, while at high doses styrene-7,8-oxide is the more effective alkylator.

TL;DR: It is concluded that ethanol potentiates benzene toxicity by accelerating hydroxylation of benzene, a rate-limiting step of Benzene metabolism and transformation of phenol into highly toxic metabolites.

TL;DR: At least three genes regulating the cytochrome P-450 system in Drosophila have been identified and are likely to be regulated by gene(s) on the third chromosome.

TL;DR: Inhibition of, or changes in, replication in mitochondria of bone marrow cells by hydroquinone and p-benzoquinone may explain the changes in the mitochondrial genome observed in marrow stem cells in acute myelogenous leukemia and may suggest a mechanism for benzene leukemogenesis.

TL;DR: It could be established that this -SH function almost certainly is that associated with the cys-34 residue of BSA, and it was concluded that the major APAP-BSA adduct is one in which the drug is bound, via a thioether linkage at the C-3 position, to a sulfhydryl group on the protein.

TL;DR: It is proposed that initially formed phenoxy radicals or arylamine cation radicals oxidize NADH or GSH to radicals which react with oxygen to form superoxide radicals and H2O2.

TL;DR: The results confirm conclusions concerning the promutagenic nature of the alkylthymines and that the reported differences in their promUTagenicity with the various polymerases reflect different specificities of the nucleotide polymerising enzymes used.

TL;DR: The model system duplicates many of the properties of cigarette smoke including the inactivation of human alpha-1-proteinase inhibitor (a1PI), and data suggest that one possible class of species is peroxynitrates.

TL;DR: The coincidence of dinitropyrene resistance and acetyltransferase deficiency implicates acetylation as an important process in the metabolic activation of d initropyrene to a mutagenic intermediate.

TL;DR: A comprehensive mechanism of action for the gamma-diketones remains to be demonstrated, but much progress has been made toward this goal.

TL;DR: Analysis of bile collected from rats following intraportal administration of [14C]HCBD revealed the presence of both the mono- and bis-substituted GSH conjugates of HCBD as well as additional 14C-containing metabolites.

TL;DR: 4-5 genes determining the capacity for several reactions, being a part of the genetic regulation of the cytochrome P-450 system in Drosophila melanogaster were indicated.

TL;DR: Significant differences were found in the amounts of each of the methylpurines formed when compared among the six synthetic polynucleotides and DNA, interpreted as an effect upon alkylation which is ultimately dependent upon the base sequence.

TL;DR: The effect of patulin on tRNA aminoacylation has been determined and it is shown that at neutral and alkaline pH-values, the inactivation occurs mainly by modification of essential thiol groups of the protein, whereas at acidic pH, where the effect is the most pronounced, the modification of other amino acid residues cannot be excluded.

TL;DR: Both in vivo and in vitro data appear to demonstrate that there is no direct role for the Ah receptor or the 3-4S protein in the regulation of cytochrome P-450 by methylenedioxyphenyl compounds.