Showing papers in "Chemico-Biological Interactions in 2008"

TL;DR: The antioxidant activity of curcumin was determined by employing various in vitro antioxidant assays such as 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH*) scavenging, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging activity, N,N-dimethyl-p-phenylenediamine dihydrochloride

TL;DR: It is expected that the power of CADDD will grow as the technology continues to evolve.

TL;DR: The results of this study indicate adaptive as well a toxic responses in fish gills exposed to mixture of trace metals, which appear to compromise the antioxidant defense of gills.

TL;DR: The results of this study suggest that SNE could protect liver against the CCl4-induced oxidative damage in rats, and this hepatoprotective effect might be contributed to its modulation on detoxification enzymes and its antioxidant and free radical scavenger effects.

TL;DR: It is arrived at that a tight junction exists between methylglyoxal toxicity and free radical (particularly ROS) generation, though the toxicity of 1,2-dicarbonyl evolves even under anaerobic conditions, too.

TL;DR: The results suggested that the hypocholesterolemic effect of oleuropein, oleurpein aglycone and hydroxytyrosol-rich extracts might be due to their abilities to lower serum TC, TG and LDL-C levels as well as slowing the lipid peroxidation process and enhancing antioxidant enzyme activity.

TL;DR: Findings indicate that morin prevents lipid peroxidation, hepatic cell damage and protects the antioxidant system in N-nitrosodiethylamine-induced hepatocellular carcinogenesis in rats.

TL;DR: The present review examines how the highly specialized structure of acetylcholinesterase, with its sequestered active site, contributes to its catalytic efficacy, and discusses how the traffic of substrate and products to and from the active site is controlled.

TL;DR: It is concluded that curcumin exhibits both antioxidant/pro-oxidant activity, in a concentration dependent manner.

TL;DR: Nasturtium officinale has a high hypolipidaemic activity and this may be attributed to its antioxidative potential, and the mechanism(s) of action was evaluated.

TL;DR: The preliminary analysis of the sequences of three genomes discussed in this paper narrows down the gaps in knowledge of the B. cereus group and incite to consider a necessity of creating prophylactic vaccines against bacteria closely related to NVH391-98 and F837/76.

TL;DR: The activities possessed by C. intybus are highly desirable for the treatment of NIDDM because it reduces blood glucose levels without inducing adipogenesis in 3T3-L1 adipocytes.

TL;DR: PPE was found to offer significant protection to human erythrocyte membrane proteins from oxidative damage induced by ferrous-ascorbate, indicating that PPE is capable of protecting ery Throthrocytes against oxidative damage probably by acting as a strong antioxidant.

TL;DR: It is concluded that ursolic acid, a dietary antioxidant, mediates its protective effect through modulation of UVB-induced reactive oxygen species.

TL;DR: Both vitamin E andCurcumin are efficient in protecting testis from oxidative stress generated by T4 mainly in restoring antioxidant enzymes to the level of euthyroid animals up to some extent but vitamin E is more efficient than curcumin.

TL;DR: Results suggested Andro can inhibit Lovo cell growth by G1-S phase arrest, and was exerted by inducing the expression of p53, p21 and p16 that repressed the activity of Cyclin D1/C DK4 and/or Cyclin A/Cdk2, as well as Rb phosphorylation.

TL;DR: An essential oil from a lemon grass variety of Cymbopogon flexuosus and its major chemical constituent sesquiterpene isointermedeol were investigated for their ability to induce apoptosis in human leukaemia HL-60 cells and appeared to follow similar signaling apoptosis pathways.

TL;DR: The current understanding of Src signaling in regulating paracellular and transcellular endothelial permeability pathways and effects on endogenous macromolecule and drug delivery is discussed.

TL;DR: It is demonstrated that co-treatment with (PhSe)(2) ameliorated hepatotoxicity and cellular damage in rat liver after sub-chronic exposure with CdCl(2).

TL;DR: It is found that chronic treatment of donepezil enhanced, and scopolamine suppressed phosphorylation of cAMP response element binding protein (CREB), which was involved in cell survival, in the DG.

TL;DR: The results suggest that an extract of P. ostreatus is able to alleviate the oxidative damage caused by CCl4 in the kidneys, heart and brain of Wistar rats.

TL;DR: Results indicate that Q. infectoria galls possess potent antioxidant activity, when tested both in chemical as well as biological models.

TL;DR: It was shown that the four CYP102A1 mutants used in this study formed the same metabolites as human and rat liver microsomes, with an activity up to 70-fold higher compared to human enzymes.

TL;DR: Results suggest that ERK1/2 activation via a MEK-independent, PI3-K-dependent signaling pathway is partially responsible for the antiproliferative effects of EGCG in PC-3 cells.

TL;DR: Stevioside holds promise as immunomodulating agent, which acts by stimulating both humoral as well as cellular immunity and phagocytic function, according to present study.

TL;DR: A new prototype of polymer-derived drug delivery system, the nanoconjugate Polycefin, was tested for its ability to accumulate in tumors based on enhanced permeability and retention (EPR) effect and receptor mediated endocytosis.

TL;DR: An overview on the protective effects of HupA, which includes regulating beta-amyloid precursor protein (APP) metabolism, protecting against Abeta-mediated oxidative stress, apoptosis and mitochondrial dysfunction, as well as anti-inflammation is given.

TL;DR: Findings suggest that both vitamin E and curcumin have differential regulation on complexes I and II mediated mitochondrial respiration and have a protective role against L-thyroxine induced hepatic dysfunction and oxidative stress.

TL;DR: Exposure to carcinogens emitted from incense burning may increase health risk for the development of cancer in temple workers, according to the results of this study.

TL;DR: The supplementation of synthetic GLE from gallic acid and linoleic acid ester may have a potential hypolipidemic effect on mice fed high-fat diet, although further studies are required to prove GLE as a hypolipsidemic agent.