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Showing papers in "Chemico-Biological Interactions in 2009"



Journal ArticleDOI
TL;DR: Gallic acid protects the myocardium against isoproterenol-induced oxidative stress, and Histopathological findings of gallic acid pretreated myocardial infarcted heart confirmed the biochemical findings of this study.

297 citations


Journal ArticleDOI
TL;DR: L-adrenaline had effective in vitro antioxidant and radical scavenging activity and this study will bring an innovation for further studies related to antioxidant properties of L- adrenaline.

242 citations


Journal ArticleDOI
TL;DR: In vitro inhibitory activities of four flavonoid derivatives of quercetin, rutin, kaempferol 3-O-beta-D-galactoside and macluraxanthone are examined to show a concentration-dependant inhibition of acetylcholinesterase and BChE and several strong hydrogen bonds to several important amino acid residues of both the enzymes were showed.

213 citations


Journal ArticleDOI
TL;DR: Results of this experimental study indicated that eremanthin possessed hypoglycemic and hypolipidemic activities and hence it could be used as a drug for treating diabetes.

178 citations


Journal ArticleDOI
TL;DR: AlDH(br) cells may have some of the traditional features of stem cells in terms of being mostly dormant and slow to divide, but require support of other cells (ALDH(lo) to sustain tumor growth.

176 citations


Journal ArticleDOI
TL;DR: The results strongly support that A. nilotica bark prevents lipid peroxidation (LPO) and promote the enzymatic and non-enzymatic antioxidant defense system during NDEA-induced hepatocarcinogenesis which might be due to activities like scavenging of oxy radicals by the phytomolecules in ANBE.

160 citations


Journal ArticleDOI
TL;DR: Evidence is provided, for the first time, that resveratrol exerts a significant chemopreventive effect on DENA-initiated hepatocarcinogenesis through inhibition of cell proliferation and induction of apoptosis in Sprague-Dawley rats.

159 citations


Journal ArticleDOI
TL;DR: This study demonstrates for the first time that OMW polyphenols and especially (HT) are efficient in inhibiting hyperglycemia and oxidative stress induced by diabetes and suggests that administration of HT may be helpful in the prevention of diabetic complications associated with oxidative stress.

159 citations


Journal ArticleDOI
TL;DR: Given that LIM and OEC are excellent flavoring agents and also present gastroprotective actions, they can be regarded as a promising target for the development of a new drug for the prevention of gastric damage.

155 citations


Journal ArticleDOI
TL;DR: The results indicate that the essential oil has a promising anticancer activity and causes loss in tumor cell viability by activating the apoptotic process as identified by electron microscopy.

Journal ArticleDOI
TL;DR: The data demonstrated that the efficacy of curcumin in inhibition of cell proliferation and induction of apoptosis might occur through modulation of beta-catenin pathway in human breast cancer cells.

Journal ArticleDOI
TL;DR: Assaying the activities of key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats demonstrated a significant decline in blood glucose and glycosylated hemoglobin levels and an increase in plasma insulin level suggesting the antihyperglycemic potential of resveratrol in diabetic rats.

Journal ArticleDOI
TL;DR: Protective effects of EGb761 against Abeta toxicity may be associated with its antioxidant and platelet activating factor (PAF) antagonist activities.

Journal ArticleDOI
TL;DR: This review focuses on the recent advances in the detection and characterization of reactive metabolites by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in drug discovery and development, especially through the use of linear ion trap, hybrid triple quadrupole-linear ion trap and the high resolution LTQ-Orbitrap instruments.

Journal ArticleDOI
TL;DR: It is concluded that pre-treatment with astaxanthin attenuates cyclophosphamide-induced oxidative stress and subsequent DNA damage in mice and it can be used as a chemoprotective agent against the toxicity of anticancer drug cycloph phosphamide.

Journal ArticleDOI
TL;DR: The results of this experimental study indicated that costunolide possessed normo-glycemic and hypolipidemic activity and hence it could be used as a drug for treating diabetes.

Journal ArticleDOI
TL;DR: It was observed that phyllanthin effectively alleviated the changes induced by CCl4 in a concentration-dependent manner, with much smaller strengths as compared to P. amarus extract.

Journal ArticleDOI
TL;DR: In SK-Hep-1 cells, fucoxanthin caused cell cycle arrest at G0/G1 phase and induced cell apoptosis, as evidenced by increased subG1 cells and induction of DNA strand breaks, and the enhanced GJIC may be responsible for the increase of the intracellular calcium level, which then causes cell cycle Arrest and apoptosis.

Journal ArticleDOI
TL;DR: A status report of the human SDR superfamily is provided in terms of 3D structure determination, co-factor preferences, subcellular localisation and functional annotation and a simple scoring system for measuring structural and functional information (SFS score) has been introduced to monitor the status of 5 key metrics.

Journal ArticleDOI
TL;DR: It can be concluded that Zn supplementation during exposure to Cd may have a protective effect on lipid metabolism consisting in its ability to prevent hyperlipidemia, including especially hypercholesterolemia, and to protect from lipid peroxidation.

Journal ArticleDOI
TL;DR: Combined use of Gly and Mat could offer better liver protective and anti-hepatocarcinogenic effects than Gly or Mat alone, and could reduce the adverse effects of Gly alone by acetaminophen- induced hepatotoxicity, diethylnitrosamine-induced hepatocarc inogenesis, induction of immunosuppression, and albumen-induced swelling of rat hind paws.

Journal ArticleDOI
TL;DR: Results suggested the phlorotannin derivatives could promote cell differentiation, attenuate MMP-1, M MP-3, Mmp-13 expressions, and inflammatory response via MAPK pathway in chronic articular diseases.

Journal ArticleDOI
TL;DR: The complex interactions between ABC transporters and their lipid/sterol substrates will be discussed and analyzed in the context of their relevance to cellular function, toxicity and apoptosis.

Journal ArticleDOI
TL;DR: The pharmacokinetic and pharmacodynamic consequences indicate that acetaldehyde, rather than ethanol, is primarily responsible for the observed alcohol sensitivity reactions, suggesting that the full protection by ALDH2*2/*2 can be ascribed to the intense unpleasant physiological and psychological reactions caused by persistently elevated blood acetaldehyde after ingesting a small amount of alcohol.

Journal ArticleDOI
TL;DR: Results suggest that osthole can alleviate hyperglycemia and could be potentially developed into a novel drug for treatment of diabetes mellitus.

Journal ArticleDOI
TL;DR: While the best substrates for AKR1B10 are retinals, the high catalytic efficiency together with the protection from inactivation by NADPH suggests a role of AKR 1B10 in the detoxification of biogenic aldehydes.

Journal ArticleDOI
TL;DR: It is indicated that morin possessed anti-inflammatory and anti-cancer properties favouring suppression of DEN-induced hepatocellular carcinoma.

Journal ArticleDOI
TL;DR: The serum-free collagen sandwich culture of primary rat hepatocytes maintained liver-like features over 10 days and is therefore a suitable model for long-term toxicity and drug-drug interaction studies.

Journal ArticleDOI
TL;DR: In the human HCT116 colon cancer cell line, kaempferol induced p53-dependent growth inhibition and apoptosis and was found to induce cytochrome c release from mitochondria and activate caspase-3 cleavage.