Showing papers in "Chemico-Biological Interactions in 2012"

TL;DR: Critical answers to the etiology of childhood leukemia will require incorporating new tools into traditional epidemiologic approaches - including the classification of leukemia at a molecular scale, better exposure assessments at all points in a child's life, a comprehensive understanding of genetic risk factors, and an appraisal of the interplay between infectious exposures and the status of immune response in individuals.

TL;DR: The fact that TQ abolished a number of factors known to be involved in RA pathogenesis indicates that the administration of thymoquinone may have potential value in the treatment of inflammatory disease.

TL;DR: The effects of human ALDH isoenzymes, ALDH1A2 and ALDH2, on drug resistance and proliferation, and the specificity of DEAB as an inhibitor are explored, concluding that DEAB is not a specific inhibitor for AL DH1A1 and that Aldefluor assay is not specific for ALDH 1A1 activity.

TL;DR: Results suggest that ZnO nanoparticles induce oxidative stress in the lung in the acute phase, and intracellular ROS level had a high correlation with intracellular Zn(2+) level.

TL;DR: In this paper, the influence of quercetin on p38-MAPK and the potential regulation of the nuclear transcription factor erythroid-2p45-related factor (Nrf2) and the cellular antioxidant/detoxifying defense system related to glutathione (GSH) by p38 in HepG2 cells was investigated.

TL;DR: Nano Cur was found to be a potential formulation in oral route in combating the oxidative damage of hepatic cells and eliminating DEN induced hepatocellular cancer cells in rat whereas identical amount of free Cur treatment was found almost ineffective.

TL;DR: The results suggest that the gastroprotective activity of Zn(II)-curcumin complex might contribute in stimulating cell proliferation and adjusting the proinflammatory cytokine-mediated oxidative damage to the gastric mucosa.

TL;DR: A possible new protective role for dietary polyphenols for mitochondria, complementary of their antioxidant property is suggested, which might expand the preventive and/or therapeutic use of PPs in conditions involving mitochondrial dysfunction and associated with increased oxidative stress at the cellular or tissue levels.

TL;DR: Results indicated that diosmin (DS) has potential ameliorative effects in addition to its antidiabetic effect in type 2 diabetic rats.

TL;DR: The results indicate that ECNPs have better antioxidant and chelating potential (even at the lower dose of 1.5 mg/kg) compared to free curcumin at 15mg/kg, and indicates their neuroprotective efficacy.

TL;DR: The uptake and efflux pathways of boron, silicon, arsenic, and antimony through the cell membranes of different organisms and the protein channels involved in these processes are reviewed.

TL;DR: The findings suggest that the gastroprotective activity of ZnHMS might contribute in adjusting the inflammatory cytokine-mediated oxidative damage to the gastric mucosa.

TL;DR: The exposed findings reveal that complex I inhibition is a common deleterious effect of NSAIDs at the mitochondrial level, and that such effect is, for all tested agents, susceptible to be prevented by quercetin.

TL;DR: A potential role of malvidin-3-glucoside in NO balance and in inhibition of pro-inflammatory signaling pathways is suggested, supporting its benefits in cardiovascular health and pointing to anthocyanins as a promising tool for development of functional foods and nutraceuticals to improve endothelial function.

TL;DR: In vitro EPR and spectrophotometric studies suggest that, contrary to Fe(2+) ions, the Ce(3+) redox state at the surface of the particles is probably not an efficient catalyst of hydroxyl radical formation by a Fenton-like reaction in vivo.

TL;DR: This study shows for the first time that DCA-dependent alteration of tumor cell survival involves altered pH homeostasis and glucose metabolism, which will provide a new insight for therapeutic applications of DCA as a novel antineoplastic agent against T cell lymphoma.

TL;DR: Investigation of the mechanism of cell death induction by MLL on human breast cancer and colon cancer cells found that MLL induced apoptosis in MCF-7 and HCT-15 cells in a caspase dependent manner.

TL;DR: This investigation is the first of its kind to establish cinnamic acid as an agent whose consumption provides protection to normal cells from the toxic effects of a widely used anti-cancer drug.

TL;DR: WSFD has the potential application in cancer cell inactivation by photodynamic therapy and both chemical properties and physical properties influenced the ROS-generation abilities, cellular uptake and photodynamic activities of WSFD.

TL;DR: The effects of silibinin on liver glucose metabolism may explain its antihyperglycaemic property, and this effect was, in part, secondary to impairment in cellular energy metabolism, a finding that should be considered in its therapeutic usage.

TL;DR: Ginsenoside Rg2 suppresses the hepatic glucose production via AMPK-induced phosphorylation of GSK3β and induction of SHP gene expression and its mechanism of action is proposed.

TL;DR: Evidence is provided that dryofragin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondria-dependent pathway in dry ofragin-induced apoptosis.

TL;DR: 4-methylesculetin showed similar efficacy to that obtained with either prednisolone or sulphasalazine, both in the acute phase of colitis as well as following a curative protocol, likely related to its ability in reduce colonic oxidative stress and inhibit pro-inflammatory cytokine production.

TL;DR: The novel finding, in the present study, is that apoptosis induced by these compounds appears to be mediated, at least in part, via the inhibition of Hsp70 expression, that may be correlated with a modulation of redox-sensitive mechanisms.

TL;DR: Findings suggested that Baohuoside I might exert its cytotoxic effect via the ROS/MAPK pathway.

TL;DR: PXR-mediated effects on CYP3A and CYP7A may contribute to the hepatoprotective property of glycyrrhizin against LCA-induced liver injury.

TL;DR: Results of the present study indicated specific interaction of metals with selected ABC transport proteins takes place at both transcriptional and functional level and an active involvement of efflux pumps in Hg clearance in fish is suggested.

TL;DR: A promising role is suggested for CAPE as mitochondria-targeted antioxidant to combat the renal toxicity of cadmium in kidney mitochondria.

TL;DR: In this paper, Hcy-induced endoplasmic reticulum (ER) stress with suppression of the nuclear factor-erythroid-2-related factor 2 (Nrf2)-dependent antioxidant protection in lens epithelial cells (LECs) was acutely induced by exposure of LECs to 100 μM Hcy without FCS and also by exposure to 5 mM Hcy with 10% FCS.

TL;DR: The rodent P BPK model presented here, when used in conjunction with a human PBPK model for Cr(VI), should provide a more robust characterization of species differences in toxicokinetic factors for assessing the potential risks associated with low-dose exposures of Cr( VI) in human populations.