Showing papers in "Chemico-Biological Interactions in 2013"

TL;DR: The results showed that two receptors, estrogen receptor alpha (ERα) and androgen receptor (AR), are affected by BPA in opposite direction and BPA was unable to induce functional foci in the nuclei and is consistent with the transient transfection study that BPA is unable to activate AR.

TL;DR: Results clearly indicate that activation of Nrf2 is associated with drug resistance in BEL-7402/ADM cells and chrysin may be an effective adjuvant sensitizer to reduce anticancer drug resistance by down-regulating NRF2 signaling pathway.

TL;DR: DZN induced mitochondrial-mediated apoptosis in heart tissue of rat following subchronic exposure and crocin showed protective effects against DZN cardiotoxicity by reducing lipid peroxidation and alleviating apoptosis.

TL;DR: Pre- or post-exposure administration of bioscavengers, enzymes that neutralize and detoxify organophosphorus molecules, is one of the major developments of new medical counter-measures and research efforts focus on improving its catalytic efficiency toward the most toxic isomers of nerve agents by means of directed evolution-based strategies.

TL;DR: This article serves as a comprehensive review of the current state of knowledge regarding the ALDH superfamily and the contribution of ALDHs to various physiological and pathophysiological processes.

TL;DR: A further gap exists for the treatment of patients with sustained cholinergic crisis that has to be expected after exposure to persistent nerve agents, e.g. VX, and more basic knowledge is necessary to improve substantially therapeutic options.

TL;DR: Using hidden Markov models (HMMs), this work has developed a semi-automated subclassification system for this huge family of short-chain dehydrogenases/reductases and has paved the ground for a sustainable and expandable nomenclature system.

TL;DR: The in vivo studies showed that PD significantly inhibited the growth of MDA-MB-231 xenograft tumors in BALB/c nude mice, suggesting that PD might be a potential therapeutic candidate for the treatment of breast cancer metastasis.

TL;DR: Pulmonary consequences of illicit drugs are various, resulting in both acute life-threatening conditions and long-term functional respiratory sequelae, and a better understanding of their spectrum and the implicated mechanisms of injury should help to improve patient management.

TL;DR: Recent genetic findings with the historical body of toxicological data indicating that inhibition and aging of NTE are both necessary in order to produce neuropathy from exposure to certain OP compounds need to be reconciled.

TL;DR: The involvement of up-regulated AKR1C1, AKR 1C3 and proteasome in CDDP resistance of colon cancers and support a chemotherapeutic role for their inhibitors are suggested.

TL;DR: Despite this decline, OPs and MCs still play a major role in pest control and the increasing knowledge on their target sites and metabolism may make it possible to redesign the inhibitors for insensitive AChEs and to target new sites in the cholinergic system.

TL;DR: It is suggested that NAC and SIL protect MB and/or PQ-induced hepatotoxicity by reducing oxidative stress, inflammation and by modulating xenobitic metabolizing machinery and SIL seems to be more effective.

TL;DR: It is indicated that cytotoxicity is a function of particle surface charge, the relative number of available surface binding sites, and metal ion dissolution from NPs, and the design of safer nanomaterials.

TL;DR: Naringenin showed antioxidant and renal protective effects against injuries induced by CCl4, and this was confirmed by Histopathological and electron-microscopic examinations.

TL;DR: Clinical findings from SM casualties from the Iran-Iraq War (1980-1988) are summarized, with an emphasis on cutaneous injury, and new strategies are needed to provide for optimal and rapid healing.

TL;DR: This research proved that MS(E) can simultaneous acquire precursor ion information and fragment ion data at high and low collision energy in one analytical run, which facilitated the fast structural characterization of metabolites.

TL;DR: It is concluded that mangiferin attenuates the dopaminergic neurodegeneration mainly through its potent antioxidant and antiapoptotic properties.

TL;DR: Light is shed on the potent antitumor property of the UA and can be extended further to develop therapeutic protocols for treatment of cancer.

TL;DR: It is shown that treatment with chalcone, 2-hydroxychalcone, and xanthohumol for 24h inhibited the growth of MDA-MB-231 cells with IC50 values of 18.1, 4.6, and 6.7 μM, respectively, which suggests a potential application of these chalcones as anticancer agents that can alleviate malignant progression of TNBC.

TL;DR: The currently drafted framework is based on virtually complete ignorance of all well established and taught principles of pharma cology and toxicology, of opinions raised by the European Commis sions own competent expert authority, and of critical statements made by member countries, while avoiding asking for support from the European Commission’s own scientific expert committees.

TL;DR: The phosphoramidated-hAChE choline-binding site mutant Y337A showed three-times enhanced reactivation capacity with non-triazole imidazole containing aldoximes and acetamide derivative than with 2PAM, implying that geometry of oxime access to the phosphorus atom conjugated to the active serine is an important criterion for efficient reactivation.

TL;DR: It is suggested that evodiamine induces intracellular calcium/JNK signaling-mediated autophagy and calcium/mitochondria-mediated apoptosis in glioma cells.

TL;DR: The Hansch model showed that increasing neuropathic potential correlated with rising R hydrophobicity; moreover, OPC binding to scavenger EOHs (BChE and CaE) had different effects on potential acute and delayed neurotoxicity.

TL;DR: The pharmacological therapy rapidly treated the initial signs of poisoning, whilst the bioscavenger provided prolonged protection by neutralising further nerve agent entering the bloodstream and preventing it from reaching the target organs.

TL;DR: Results suggested that VOmor complex could serve as promising pharmacologically active substance against breast cancer treatment and not affect the normal proliferation of the breast epithelial mammal cells.

TL;DR: It is shown that PQ treatment reduces the cell viability and proliferation and induces reactive oxygen species (ROS) production in a dose-dependent manner and apoptosis induced by PQ was significantly increased at a concentration of as low as 1 μM.

TL;DR: Clinical studies in pregnancies complicated by inflammatory conditions such as preeclampsia and gestational diabetes support these findings, although further studies are required to determine the clinical relevance of the relationships between placental ABC transporter expression and activity, and placental function in stressed pregnancies.

TL;DR: It is shown that the pomegranate-derived polyphenols, punicalagin and ellagic acid, inhibit MMP-13-mediated degradation of CII in vitro, which is correlated with an over-expression and over-activation of matrix metalloproteinases (MMPs).

TL;DR: The findings of a functional expression of TRPA1 in pulmonary epithelial cells provide causal evidence for a non-neuronal TRPA 1-mediated control of inflammatory responses elicited uponTRPA1-mediated registration of toxic inhalants in vivo.