Showing papers in "Chemico-Biological Interactions in 2017"

TL;DR: This review includes the characterisation of AgNPs and antibacterial activity of such nanoparticles with size, shape and method used for this study.

TL;DR: The application of metabolomics has shown potential in bioactivity evaluation and action mechanism of TCM as well as pharmaceutical research and development.

TL;DR: Findings demonstrated the hepatoprotective nature of CGA by attenuating the pro-inflammatory and apoptotic mediators and improving antioxidant competence in hepatic tissue and imply that CGA has perfective effect against MTX-induced liver injury.

TL;DR: An overview of QQ enzyme related applications is drawn, covering several economically important fields such as agriculture, aquaculture, biofouling and health issues, and the possibility of resistance mechanism occurrence to QQ strategies is discussed.

TL;DR: The present findings collectively suggest that AGN exerts its neuroprotection in ROT model of PD and may act as an effective agent for treatment of PD.

TL;DR: 18β-GA protected against MTX-induced liver injury, possibly by activating Nrf2 and PPARγ, and subsequent attenuation of inflammation, oxidative stress and apoptosis, and therefore can provide protection against MTx-induced hepatotoxicity.

TL;DR: Overall, the protective effects of 6-GRF on CPF-induced toxicity in the brain and reproductive organs of rats may be due to its potent antioxidative, anti-inflammatory and antiapoptotic properties.

TL;DR: Hesperidin can inhibit hepatocarcinogenesis by suppressing oxidative stress, inflammation, cell proliferation, TGF-β1/Smad3 signaling and collagen deposition and these effects are suggested to be mediated by activating Nrf2/ARE/HO-1 and PPARγ pathways.

TL;DR: It is found that miR-221/222 were overexpressed in highly aggressive breast cancer MDA-MB-231 cells, that are enriched in markers for epithelial-mesenchymal transition (EMT) and BCSCs, than in MCF-7 cells.

TL;DR: It is found that treatment with natural products, ergone, alisol B 23-acetate and pachymic acid B inhibit extracellular matrix accumulation in HK-2 cells and attenuated podocyte injury, in part, by inhibiting Ang II induced RAS/Wnt/β-catenin axis activation.

TL;DR: Evaluated the effect of SAL on high glucose (HG)-induced oxidative stress and ECM accumulation in rat glomerular mesangial cells and showed that SAL treatment alleviated HG-induced cell proliferation.

TL;DR: In this article, the role of JNK in colistin-induced neurotoxicity and demonstrated the relationship among JNK, p53 and ROS in PC-12 cells by western blotting, electron microscopy and immunofluorescence/fluorescence microscopy.

TL;DR: The possibility of BPAF to negatively impact female fertility is demonstrated and the mechanisms that BPAf disrupted mouse oocyte maturation are revealed by affecting cytoskeletal dynamics, inducing oxidative stress, increasing DNA damage, and changing the status of epigenetic modifications.

TL;DR: Results suggest that LYC significantly combated NaF-induced ameloblasts apoptosis and dental fluorosis by attenuation oxidative stress and down-regulation Caspase pathway.

TL;DR: It is demonstrated that apigenin might exert a protective effect on alcohol-induced liver injury, and its mechanisms might be related to the regulations of hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression.

TL;DR: Results suggest that four tested dandelion fractions, especially phenolic fractions from petals which are recognized as better than leaves source of flavonoids, may be a new and promising source of natural compounds with antioxidant activity beneficial for diseases-associated with oxidative stress, and with changes of hemostasis.

TL;DR: Results obtained confirm the superiority of QP over free quercetin at the same doses as a promising hormone replacement therapy and establish stability of the formed nanoparticles via zeta potential determination.

TL;DR: Genistein could be a novel therapeutic/nutraceutical agent in treating chronic liver damage and liver fibrosis and a possible mechanism of action in which Smad7-induced inhibition of TGF-β/Smad2/3 can be a central mechanism by which Genistein protects liver from chronic injury is suggested.

TL;DR: It was shown that butyrate induced ROS, which in turn induced autophagy via inhibition of akt/mTOR pathway, which could be considered as a potential candidate for HCC treatment.

TL;DR: The results here reported confirm the promising biological properties of depsidone compounds, and may offer a further impulse to the development of analogues with more powerful efficiency against melanoma cells.

TL;DR: Fermented beverages of oak effectively down-regulated the production of NO, while pro-inflammatory cytokines (TNF-alpha and IL-6) in macrophages were stimulated with LPS, and phytochemical compounds present in KAO decrease oxidative stress.

TL;DR: Results reveal that inhibition of A549 cell invasion by solasodine may be, at least in part, through blocking MMP expression, and demonstrate an attractive therapeutic potential for solasadine in lung cancer anti-metastatic therapy.

TL;DR: It is shown that naringin promotes fracture healing through stimulating angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.

TL;DR: Synthesis of new complexes of hydroxyflavones allows for improvement biological properties, stability, water-solubility, hydrophilicity, bioavailability, and their biological activity comparing with the parent hydroxyFlavones.

TL;DR: The results showed that all of the studied compounds in a wide range of concentrations increased DCF fluorescence which suggests a stimulation of ROS production, Nevertheless, these new compounds showed cytotoxic and proapoptotic properties only at high (10-100 μM) concentrations.

TL;DR: Taurine protected against NaF-induced neurotoxicity via mechanisms involving the restoration of acetylcholinesterase activity and antioxidant status with concomitant inhibition of lipid peroxidation in the brain of rats.

TL;DR: Scientific findings support genistein's potential as a promising anti-hypertensive agent in different experimental models, however, clinical trials are very limited and more research will be required beforegenistein intake can be recommended as part of therapies targeting raised blood pressure.

TL;DR: The results indicate that natural pyrethrins has potentially exert adverse effects on human health by inducing caspase-dependent apoptosis in hepatocytes through Bax- and Bcl-2-mediated mitochondrial pathway.

TL;DR: The findings suggest that the effective inhibition of Cd2+-induced apoptosis in PC12 cells by Zn2+ might be due to suppression of mitochondrial apoptosis pathway and inhibition of Bax-induced production of reactive oxygen species.

TL;DR: Results suggested that curcumin can attenuate skeletal muscle mitochondrial impairment in COPD rats possibly by the up-regulation of PGC-1α/SIRT3 signaling pathway.