Showing papers in "Chemico-Biological Interactions in 2019"

TL;DR: Various novel dosage forms like nanoparticles, liposomes that can be used efficiently for the delivery of various oligonucleotides such as siRNA and miRNA are focused on.

TL;DR: In this review, various modes of nano drug delivery options like liposomes, dendrimers, quantum dots, carbon nanotubes and metallic nanoparticles have been discussed.

TL;DR: In conclusion, many phytochemicals in combination with existing drugs were found to act as resistance modifying agents and proper combinations may rescue the efficacy of important lifesaving antimicrobial agents.

TL;DR: The various types of carbon-based nanomaterials and methods that use for determining these toxic effects that are reported recently in the papers are described.

TL;DR: Hesperetin may be a potential protectant against cisplatin-induced nephrotoxicity, and western blotting of renal tissue revealed that he Speretin activates Nrf2 in a dose-dependent manner, attenuates the MAPK signaling pathway against inflammation, and inhibits the expression of apoptotic proteins to protect kidneys from AKI caused by cisplarin.

TL;DR: Recent trends in various novel drug delivery carriers including microparticles, microemulsions, microspheres, nanoparticles, liposomes, dendrimers, solid lipid nanocarriers etc which can help in combating the oxidative stress in CRDs and ultimately reducing the disease burden and improving the quality of life with CRDs patients are highlighted.

TL;DR: The genotoxicity of different types of metal NPs and the redox mechanisms that amplify the toxicity of these NPs are reviewed.

TL;DR: It is demonstrated that MFA attenuated liver fibrosis and hepatic stellate cell activation by inhibiting the TGF-β1/Smad and NOX4/ROS signalling pathways.

TL;DR: The analysis demonstrates that the LNT single-hit model was inappropriately adopted for governmental risk assessment, regulatory policy, practices, and for risk communication.

TL;DR: The potential role of Ox-PL in Dox-induced pathology is discussed and the notion that a better understanding of the field could point to new strategies to prevent cardiotoxicity is supported.

TL;DR: The NDDS are promising for sustained drug delivery, reduced therapeutic dose, improved patient compliance and reduce drug toxicity, and the physiochemical properties and functional moieties of the NDDS attributes to enhanced macrophage targeting and uptake.

TL;DR: The results indicate that quercetin induces mitochondrial-mediated apoptotic pathway and thus it inhibits the growth of metastatic ovarian cancer cells.

TL;DR: Development and properties of new human acetylcholinesterase (AChE) crystals of space group P31 and a new unit cell, amenable for room-temperature X-ray diffraction studies are described and studied for better informed structure-based design under closer-to-physiological temperature conditions.

TL;DR: This review summarized resveratrol's discovery, sources and isolation methods, administration methods, effects in different types of leukemia, pharmacokinetics and toxicities, aiming to exploit resver atrol as a potential drug candidate for anti-leukemia.

TL;DR: Among the many existing spices, turmeric is one of the most studied for its antioxidant, anti-inflammatory, antibacterial and anticancer properties.

TL;DR: It is found that angiotensin II-induced cardiac dysfunction and fibrotic responses were dampened by irisin treatment in mice, and irisin is identified as a promising anti-fibrotic therapeutic for angioten II-related cardiac fibrosis.

TL;DR: It is depicted that chrysin exerted neuroprotective effect in TAA-induced HE rats, evidenced by improvement of cognitive deficits, motor incoordination and histopathological changes such as astrocyte swelling and vacuolization; hallmarks in HE, via reducing hyperammonia, ameliorating hepatic function.

TL;DR: In vivo, oral administration of PIC suppressed STZ-induced inflammation, oxidative stress hypertrophy, fibrosis and fibrosis in diabetic rats, thereby relieving cardiac dysfunction and improving both fibrosisand pathological changes in cardiac tissues of diabetic rats.

TL;DR: It is demonstrated that COS exhibited a significant protective effect on cardiac tissue by not only inducing a decrease in body and heart growth but also ameliorated oxidative damage and ECG alterations in DOX-treated rats.

TL;DR: Directed evolution experiments, including site-saturation mutagenesis, targeted error-prone PCR, computational design, and quantitative library analysis, have systematically improved the catalytic activity against the chemical warfare nerve agents, leading to the identification of variants that are highly effective at detoxifying both G-type and V-type nerve agents.

TL;DR: BCP significantly ameliorated all diet-induced alterations in a CB2R-dependant manner as it improved glycemic parameters, dyslipidemia, and vascular oxidative stress and inflammation and may represent a more potent alternate to pioglitazone avoiding its side effects in the treatment of insulin resistance and vascular inflammation.

TL;DR: It is concluded that HSN has significant anti-inflammatory activities and reduces the potential of MMPs in rheumatoid arthritis and the degree of polarization of macrophages to M1.

TL;DR: Morin prevented tissue damage in liver and kidney tissues caused by DOX and prevented the increase in DOX-induced Bax expression and decrease in Bcl-2 level, AQP-2 and nephrin expression, according to histopathological examination.

TL;DR: It is demonstrated that Glaucocalyxin A inhibited EMT and TGF-β1-induced EMT by inhibiting TGF -β1/Smad2/3 signaling pathway in osteosarcoma.

TL;DR: A new lnc-p21-miR-625-TRPM2 regulatory network that lnc -p21 regulated MPP + -induced neuronal injury by sponging miR- 625 and upregulating TRPM2 in SH-SY5Y cells, which provide a better understanding for the pathogenesis of PD.

TL;DR: The results of this study provided convincing evidence of significant pharmacological properties of isoquercetin in context of its ability to inhibit the oxidative stress elicited by the STZ through generation of the free radicals and regulation of the expression of Nrf2 pathway-associated proteins and genes and it also reduced the burden of hyperlipidemia and inflammation.

TL;DR: It is suggested that post-CCI cryptotanshinone treatment reduced the surgery-induced neuropathic pain by suppressing PI3K/Akt signaling therefore inhibited inflammation.

TL;DR: It is demonstrated that miR-532-5p inhibited the proliferation and invasion of bladder cancer cells by targeting HMGB3 and downregulating Wnt/β-catenin signaling, suggesting a tumor suppressive role of miR/HMGB3 in bladder cancer.

TL;DR: The novel mechanism of BCP in cardioprotective effect of a selective CB2 receptor agonist; β-Caryophyllene (BCP), a natural bicyclic sesquiterpene, against DOX-induced chronic cardiotoxicity in rats is revealed.

TL;DR: It is found that miR-543 was significantly downregulated in 69 CC tissue samples and cell lines when compared to adjacent normal tissues and cell line, which might serve as a potential biomarker for CC diagnosis and therapy.