Showing papers in "Chemico-Biological Interactions in 2020"
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TL;DR: Flavonoids and their derivative may represent target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections.
222 citations
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TL;DR: The findings of pyroptosis-dependent cancer progression, new drugs and therapeutic target may lead to a promising, novel therapeutic approach for cancer patients.
148 citations
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TL;DR: This review summarizes the present information concerning NAFLD after HFD exposure, as well as discusses possible mechanisms through which it may arise, and proposes a variety of hits acting together to offer a more accurate explanation for progression ofNAFLD.
82 citations
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TL;DR: The antimicrobial action of ROS is reviewed, challenges to ROS hypothesis, researches to encourage ROS-mediated antimicrobial lethality, recent developments in antimicrobial agents using ROS as an antimicrobial strategy, safety concerns related to ROS, and future directions in ROS research are reviewed.
68 citations
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TL;DR: This short review focuses on the recent research on potential cytotoxicity of iron-based nanomaterials, and the potential implications of this new knowledge in medicine, chemistry and biology.
63 citations
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TL;DR: The structures, conformations, and catalytic mechanisms of P450 2E1 have some unusual features among P450s, which may have relevance in the rates of oxidation of drugs, particularly acetaminophen and anesthetics.
55 citations
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TL;DR: Imidamide 4 can be viewed as a promising hit dicationic compound with good cytotoxic and apoptotic inducing activity against breast cancer that can be adopted for future optimization.
51 citations
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TL;DR: Rapamycin represents a potent candidate for the treatment of COVID-19 than antiviral drugs as its efficacy is less likely to be dampened with high mutation rate of viral RNA, and the inhibitory effect of rapamycin on cell proliferation may aid in reducing viral replication.
51 citations
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TL;DR: It is demonstrated that TQ can reverse EMT by upregulating epithelial markers, such as E-cadherin, and downregulating mesenchymal markers, and provide new evidence for the development of TQ as a novel treatment for metastatic bladder cancer.
50 citations
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TL;DR: This study indicated that artesunate induces autophagy dependent apoptosis through upregulating ROS and activating AMPK-mTOR-ULK1 pathway in human bladder cancer cells.
40 citations
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TL;DR: Calycosin treatment markedly improved the aforementioned makers of renal injury and dysfunction, modulated IL33/ST2 signaling, inflammatory cytokines, oxidative stress and fibrotic processes, accompanied by improvement of T2DM-induced renal ultramicroscopic and histopathological alterations.
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TL;DR: The burden of cancers caused by alcohol consumption might be decreased through (i) individual-level and societal-level interventions that reduce alcohol consumption, and (ii) measures that target those risk factors that interact with alcohol consumption to increase the risk of cancer or that directly affect therisk of alcohol-related cancers.
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TL;DR: Twenty potential alkaloid molecules that possess antiviral activity against different viral diseases have been taken into consideration and scrutinized using Lipinski's rule and two alkaloids namely thalimonine and sophaline D showed potential activity to inhibit the Mpro but to confirm the claim further in-vitro studies are required.
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TL;DR: An update of the pharmacological properties of ICT and its metabolic characteristics is provided and the design of derivatives, including both natural products and synthetic molecules, such as SNG1153 also in clinical trial are addressed.
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TL;DR: It is suggested that SSA may attenuate OVA-induced allergic rhinitis through regulating the expression of IL-6/ROR-γt/STAT3/IL-17/NF-κB signaling.
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TL;DR: This study summarizes the experimental evidences on natural products moieties and their components that illustrates therapeutic efficacy on respiratory disorders.
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TL;DR: A mini review summarizes the various function of Carbon Oxide Releasing Molecules, a novel group of chemical compounds capable of controlled CO release directly in tissues or organs.
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TL;DR: Theranostics has successfully paved a path to a new era of drug design and development, in which nanomaterials and imaging contribute to a large variety of cancer therapies and provide a promising future in the effective management of various cancers.
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TL;DR: This review periodically summarized the recent advances in regard to PPI's anti-tumor propensities in various cancers and the underlying mechanisms for future prospective research.
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TL;DR: The ameliorative consequence of PCA on ethanol induced oxidative stress and apoptosis was achieved by suppressing the expression of CYP2E1 and overexpressing Nrf2 and its target protein HO-1 in rat liver tissue and PCA was marked to be an effective antioxidant with notable hepatoprotection.
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TL;DR: Natural products are highly diverse in their modulatory action on TRPV1, and many gaps in natural product research are present in distinguishing modality-specific from polymodal antagonists.
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TL;DR: The future prospect for SCD-mediated signaling crosstalk as a potential therapeutic target for cancer is discussed and the novel positive loop to amplify Wnt signaling through stabilization of LRP5/6 in both hepatic stellate cells and liver tumor-initiating stem cell-like cells is discussed.
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TL;DR: Taxifolin inhibited iron-induced apoptosis and enhanced hepatocellular survival as demonstrated by decreased activity of caspase-3 and activation of the pro-survival signaling PI3K/AKT, respectively, and western blotting analysis revealed that taxifolin enhanced liver regeneration as indicated by increased PCNA protein abundance.
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TL;DR: In conclusion, β-carboline alkaloids could be introduced as novel candidates in cancer therapy through targeting cell division cycle at different phases.
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TL;DR: Findings make erythrocytes highly valuable cells for in vitro biocompatibility assessment, cytotoxicity screening of a wide variety of substances as well as drug delivery.
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TL;DR: It is shown that apigenin attenuates PH via inhibiting the HIF-1α-KV1.5 channel pathway to induce PASMC mitochondria-dependent apoptosis and activation of hypoxia-induced factor 1α signalling.
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TL;DR: Overall, the present study showed that PAX, as a monotherapy, demonstrated acquired resistance possibly by increasing MDR-1 expression and enriching CSCs population, as evidenced by increased ALDH-1.
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TL;DR: Andrographolide acts as a protective agent for the treatment of complete freund's adjuvant induced rheumatoid arthritis by inhibiting lipid peroxidation and nitrite/nitrate levels in a dose-dependent manner, enhancing antioxidant enzyme activity, reducing levels of chemokines and inflammatory factors, preventing neutrophil accumulation and infiltration.
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TL;DR: The expression of six iron regulatory genes in twenty-one human colorectal cancer (CRC) biopsies and matched normal colonic tissue show that only hepcidin and ferritin heavy chain expression were increased in CRCBiopsies as compared to matched normal tissues.
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TL;DR: It is found that in vivo treatment with Tan IIA significantly relieved silica-induced lung fibrosis in a silicosis rat model by histological and immunohistochemical analyses and in vitro mechanistic investigations revealed that Nrf2 activation partially mediates the suppression effects ofTan IIA on EMT and TGF-β1/Smad signaling pathway activation induced by silica exposure.