Showing papers in "Clinica Chimica Acta in 2010"

TL;DR: This paper summarizes and critically assesses the current studies focusing on adverse effects of Ag NPs on human health and the mechanisms for Ag NP induced toxicity include the effects of this particle on cell membranes, mitochondria and genetic material.

TL;DR: In this paper, the role of miR-21 in non-small cell lung cancer (NSCLC) and to clarify the regulation of PTEN by miR21 and determine mechanisms of this regulation were identified.

TL;DR: Evidence for and against the role of increasing physical activity in the reduction of chronic inflammation is summarized and the effects of exercise training on systemic low-grade inflammation are summarized.

TL;DR: Recent and ongoing research indicates the role of MCP-1 in various allergic conditions, immunodeficiency diseases, bone remodelling, and permeability of blood - brain barrier, atherosclerosis, nephropathies and tumors and hence M CP-1 inhibition may have beneficial effects in such conditions.

TL;DR: To validate the actual clinical validity of various cfDNA alterations as potential cancer biomarkers in practice for individual tumor types, the main problems of the observed uncertainties must be considered in future studies.

TL;DR: It is unclear however, whether administering systemic therapy based on this lead-time improves patient outcome, and expert panels disagree on the utility of regularly measuring CA 15-3 in the postoperative surveillance of asymptomatic women following a diagnosis of breast cancer.

TL;DR: This review summarizes a diversity of mechanisms proposed for LDL oxidation serving for the so-called "LDL oxidation hypothesis of atherogenesis", and finds that the physiologically relevant mechanisms are still imperfectly understood.

TL;DR: Evidence from cardiac studies is presented supporting the presence of membranous blebs, enabling troponin to be released from cardiac cells due to ischemia alone, without necrosis.

TL;DR: The data showed for the first time in humans that both, lower 25(OH)D and 1,25( OH)2D values are independently related to an upregulated circulating RAS and emerged as independent predictors of plasma renin and angiotensin 2 concentrations.

TL;DR: In this article, the role of nitric oxide pathway, adipocytokines and hemodialysis-induced endothelial dysfunction is discussed in chronic kidney disease, including thrombosis, hypertension, renal failure and atherosclerosis.

TL;DR: Ion Selective Electrodes are used to measure some of the most critical analytes on clinical laboratory and point-of-care analysers and they are not free of interferences.

TL;DR: Only well-founded biomarker identification, normalization and data processing will provide clinically relevant information from breath analysis, andExhaled substance concentrations may depend on a variety of parameters other than the disease under investigation.

TL;DR: Measurements of total plasma fatty acids could provide insights into the relationships between diet and atherosclerotic disease and the n-6/n-3 ratio may constitute a predictor of low-grade inflammation and coagulation.

TL;DR: The metabolic profiling of urine samples from depression model rats is investigated to find potential disease biomarkers and research pathology of depression to further understanding the pathophysiology of depression and assisting in clinical diagnosis of depression.

TL;DR: Plasma metanephrines measured by LC-MS/MS are a reliable and sensitive test for the biochemical detection of pheochromocytoma.

TL;DR: The combination of magnetic particles and their fine actuation with electromagnets permits the rapid and sensitive detection of cTnI in a finger-prick blood sample with a turnaround time of 5 min, well suited for demanding point-of-care diagnostic applications.

TL;DR: Lyso-Gb(3) is a reliable independent biomarker for clinically important characteristics of Fabry disease and correlated well with a number of indicators of disease severity.

TL;DR: A robust, high-throughput, LLE-LCMSMS method for accurate and precise quantitation of 25( OH)D3 and 25(OH)D2 in serum that offers a cost-effective alternative to immunological methods for use in the routine clinical biochemical laboratory is described.

TL;DR: Modest inter-laboratory variability persists in serum 25(OH)D measurement, and the National Institute of Standards and Technology 25( OH)D Standard Reference and calibration materials will further improve between- laboratory agreement for chromatography-based assays.

TL;DR: The Sysmex UF1000i was capable of improving the efficiency of a routine microbiology laboratory by processing 100samples/h and providing negative results in a few minutes, thus reducing unnecessary testing with an acceptable number of false negative results.

TL;DR: In hypertriglyceridemia TG lowering therapy (fibrates or fish-oil) is essential to prevent cardiovascular disease and pancreatitis and in HTG patients supersaturated bile may be related to the presence of obesity rather than to HTG itself.

TL;DR: Results suggest that inhibition of COX-1, despite causing intestinal hypermotility, bacterial invasion and iNOS expression, up-regulates the expression ofCOX-2, and the PGE(2) derived from COX -2 counteracts the deleterious events caused by COx-1 inhibition and maintains mucosal integrity.

TL;DR: It is proved that IAs may give a FT4 pattern during pregnancy similar to that obtained with an equilibrium dialysis isotope dilution-mass spectrometry (ED ID-MS) candidate reference measurement procedure.

TL;DR: The new high-sensitivity troponin T (TnT) assay is the most powerful biomarker for prognostic classification for all-cause mortality of all the commonly used biomarkers for the renal-dialysis population and suggests that cardiac biomarkers have a different prognostic ability for different time frames.

TL;DR: Simple and readily available biomarkers have low accuracy in predicting liver fibrosis and more advanced markers have low cost-benefit ratio, therefore liver biopsy remains the "gold standard" for diagnosis of fibrosis.

TL;DR: The study revealed that the carcinogenic processes are significantly affecting the trace metal burden and mutual variations in the cancerous patients compared with the controls.

TL;DR: In this article, the authors investigated metabolite profiles in the serum of 30 patients with ALS, 10 patients of Hirayama disease, which served as a neurological disease control and 25 healthy controls by using H NMR spectroscopy.

TL;DR: The sediMAX is well able to count and identify RBC, WBC, squamous epithelial cells, yeast, bacteria and calcium-oxalate crystals and recognition of pathological casts and non-squamous epithelium cells is adequate but needs to be improved.

TL;DR: This review will discuss the molecular, physiological and biochemical aspects of histone acetylation and focus on the interplay of hist one acetyltransferases (HATs) and histone deacetylases (HDACs) in different disease states.

TL;DR: The current understanding of the involvement of AEA and related ECS elements in regulating oogenesis, embryo oviductal transport, blastocyst implantation, placental development and pregnancy outcomes, and sperm survival, motility, capacitation and acrosome reaction is summarized.