Showing papers in "Clinica Chimica Acta in 2020"

TL;DR: Low platelet count is associated with increased risk of severe disease and mortality in patients with COVID-19, and thus should serve as clinical indicator of worsening illness during hospitalization.

TL;DR: Current therapeutic options, preventive methods and transmission routes of COVID-19 are discussed and infection prevention, early viral detection and identification of successful treatment protocols provide the best approach in controlling disease spread.

TL;DR: The results of this concise meta-analysis of the literature would suggest that serial procalcitonin measurement may play a role for predicting evolution towards a more severe form of disease.

TL;DR: The RT-PCR detection of viral nucleic acid test (NAT) was one of the most quickly established laboratory diagnosis method in a novel viral pandemic, just as in this COVID-19 outbreak, and viral NAT played an important role in identifying SARS-CoV-2 infection.

TL;DR: The mechanisms of SARS-CoV-2-induced cytokine storm are reviewed in detail based on the current discovered researches, and some valuable medication ideas for the targeted cytokines drug researches and treatment are put forward.

TL;DR: The underlying pathogenesis and the interaction between multiple systems, resulting in propagation of immunothrombosis, are discussed and may lead to both an improved understanding of COVID-19 pathophysiology and identification of innovative and efficient therapeutic targets to reverse the otherwise unfavorable clinical outcome of many of these patients.

TL;DR: The kinetics of IgM, IgA and IgG SARS-CoV-2 antibodies in COVID-19 patients with confirmed (rRT-PCR) infection found that the IgA response appears and grows early, peaks at week 3, and it is stronger and more persistent than the IgM response.

TL;DR: Dynamic surveillance of peripheral blood system especially eosinophils is helpful in the prediction of severe COVID-19 cases.

TL;DR: Patients with blood group A had an increased risk for infection with Sars-CoV-2, whereas blood group O was associated with a decreased risk, indicating that certain ABO blood groups were correlated with SARS-Cov-2 susceptibility.

TL;DR: This review summarizes and discusses previous and recent findings regarding the relationship between hyperandrogenism, insulin resistance, obesity and PCOS.

TL;DR: LDH and CRP should be considered a useful test for the early identification of patients who require closer respiratory monitoring and more aggressive supportive therapies to avoid poor prognosis.

TL;DR: It is suggested that laboratory medicine may also be of significant assistance when differentiating between severe and non-severe COVID-19 patients.

TL;DR: The lipid profile of a severe patient showed that serum cholesterol concentration significantly decreased in the early stage and returned to be normal in the recovery period, and decreased serum HDL-cholesterol is associated with the severity of COVID-19 infection.

TL;DR: A new perspective for Atherosclerosis therapy is provided by summarizing the relationship between macrophage polarization and atherosclerosis, as well as treatment targeting macrophages polarization.

TL;DR: The results obtained indicate that, for CLIA assays, it might be possible to define thresholds that improve the negative likelihood ratio, and improved the overall inter-assay agreement, paving the way to a better harmonization of serologic tests.

TL;DR: Concentrations of CRP remained increased in patients who died in COVID-19 infection and could be a promising biomarker for accessing disease lethality, as demonstrated by a meta-analysis.

TL;DR: A head-to-head comparison of the fully-automated Elecsys® Anti-SARS-CoV-2 immunoassay with the EDITM enzyme linked immunosorbent assays (ELISA) for the detection of SARS- CoV- 2 antibodies in human plasma indicates a high sensitivity and specificity for the ElecsYS® assay and an acceptable agreement with the EditorialM ELISAs.

TL;DR: This review will discuss the performance of different laboratory diagnostic tests and platforms, as well as suitable clinical samples for testing, and related biosafety protection, for the diagnosis of COVID-19 caused by SARS-CoV-2.

TL;DR: Signs that may most effectively predict a non-severe COVID-19 patient develop into a severe patient are found, especially lymphocytes, CRP, PCT, ALT, AST, LDH, D-dimer, CD4 T cells and IL6, which provide valuable signals for preventing the deterioration of the disease.

TL;DR: A more comprehensive understanding of this unique lncRNA is critical to elucidating the pro-oncogenic function of HOTAIR its potential application in diagnosis, prognosis and treatment.

TL;DR: Emerging evidence is summarized to discuss the progressive understanding of pyroptosis and the pathways, effect and effectors of pyproptosis, as well as the role of pyrptosis in CVD.

TL;DR: Evaluation of pharyngeal swab and fecal samples can improve the positive rate of nucleic acid detection and cause some hematological indices changes in the COVID-19 patients.

TL;DR: The proposed multiplex rRT-PCR methodology will enable highly sensitive detection of SARS-CoV-2 RNA, reducing reagent use and cost, and time required by clinical laboratory technicians.

TL;DR: Low CD3+, CD4+, CD8+ T lymphocyte counts may reflect the severity of the COVID-19, and monitoring T cell changes has important implications for the diagnosis and treatment of severe patients who may become critically ill.

TL;DR: The results of studies concerning the impact of FMT on weight gain, immunological response and the treatment of neurological and gastrointestinal diseases and cancer are presented.

TL;DR: The up-to-date applications of exosomes, derived from various sources, in the prognosis and diagnosis of several diseases including cancer, cardiovascular and regenerative diseases as well as, arthritis, neurological diseases, and diabetes mellitus are provided.

TL;DR: Lymphopenia and eosinopenia may serve as predictors of disease severity and disease progression in CO VID-19 patients, and enhancing the cellular immunity may contribute to COVID-19 treatment.

TL;DR: Bnip3 plays an important role in mitochondrial dysfunction and mitophagy homeostasis and has emerged as a promising therapeutic target for diseases of secondary mitochondrial dysfunction.