Showing papers in "Clinical Biochemistry in 2000"

TL;DR: Lead, but not cadmium crossed easily the placental barrier, indicating that lead might have negative influence on growth in children even at very low exposure levels and there was a depletion of maternal stores of essential elements with increasing parity.

TL;DR: Findings may support that reactive oxygen species increased in malignant cells, and may cause overexpression of antioxidant enzymes and the consumption of coenzyme Q10.

TL;DR: The first report describing significant elevations of hK6 concentration in serum of ovarian cancer patients is described, suggesting that hK 6 may represent a potential new biomarker for diagnosis and monitoring of ovarian carcinoma.

TL;DR: If M-2 promotes release of cytokines in vivo, these may mediate some of the toxic actions of MPA.

TL;DR: By using a validated modification of HP LC-based TBA method, the total plasma MDA in 16 Taiwanese college students was found to be 1.54 microM, which was relatively high compared to those obtained by other HPLC-based method, primarily due to the release of protein-bound MDA by alkaline hydrolysis.

TL;DR: Benefits of point-of-care testing include better therapeutic turnaround times, decreased blood loss as a result of reduced phlebotomy secondary to clinical improvement, and diminished resource utilization.

TL;DR: This is the first reported sensitive immunofluorometric procedure for quantifying hK6 protein, a secreted proteolytic enzyme that is found at high levels in cerebrospinal fluid and all breast secretions.

TL;DR: Phe could protect against the direct action of (*)OH radicals on brain AChE and in this way it might be useful in the prevention of certain cholinergic neural dysfunctions.

TL;DR: The first report describing significant elevations of cerebrospinal fluid and plasma and whole blood hK6 concentration in AD patients, in comparison to controls is described, suggesting that hK 6 may constitute a new biomarker for diagnosis and monitoring of AD.

TL;DR: There was an inverse relationship between the severity of the retinopathy, i.e., neovascularization, and serum 1,25(OH)2D3 concentrations, being the lowest in PDR and the highest in diabetic patients without Retinopathy (NDR) patients.

TL;DR: Research into the mechanisms and pharmacological treatment of vascular disease will provide novel management strategies in the very near future and a risk-stratifying algorithm incorporating hs-CRP and total cholesterol to high-density lipoprotein cholesterol ratio has been proposed.

TL;DR: The results show that AAG plasma concentrations are increased in these types of cancers and that changes in the expression of the genetic variants of AAG could also occur according to the type of cancer.

TL;DR: The LDL-B formula is a more reliable and accurate method than the LDL-F formula, especially at TG levels >2.26 mmol/L, although it underestimates LDL-C concentrations, and can be used in hypertriglyceridemic patients in whom the Friedewald equation is inaccurate.

TL;DR: Important alterations in metabolic parameters and biochemical abnormalities during experimentally induced liver damage are demonstrated and are compatible with the deterioration of liver functions during the pathogenesis of hepatic fibrosis.

TL;DR: Given the inability to detect mild B12 deficiency using such indicators as plasma homocysteine, and considering the substantial growth in the elderly segment of the Canadian population, occult cobalamin deficiency could become a common disorder.

TL;DR: The first, fully automated assay for the measurement ofCatalatic activity of catalase in plasma, erythrocytes, and liver is demonstrated for multiple species and is simple, precise, relatively inexpensive, and rapid.

TL;DR: Investigation of glutathione (GSH) system in different tumors revealed that measurement of some and/or all components of the GSH system might be of clinical value in some malignant cases.

TL;DR: A new assay, suitable for the measurement of Ox-LDL in human blood, which meets the requirements for routine clinical assay is developed, which had a sensitivity of 79% and a specificity of 75% for CHD.

TL;DR: Results showed significant alteration in serum and erythrocyte lipid peroxidation and ERYthrocytes antioxidant enzyme status of patients with Type 2 diabetes by dietary treatment, however, whether such alterations have clinical importance for diabetic patients needs further investigation.

TL;DR: The novel lymphocyte toxicity assay based on the mitochondrial succinate dehydrogenase (SDH) activity vs. the trypan blue exclusion is objective, faster, and has been reproducible in assessing cytotoxicity.

TL;DR: The insulin aspart-specific enzyme-linked immunosorbent assay described in this study is well suited to study the bioavailability, bioequivalence, and pharmacokinetics of this insulin analogue.

TL;DR: The group of hereditary coproporphyria patients exhibited a significantly higher excretion of urinary porphyrin precursors, delta-aminolevulinic acid and porphobilinogen and their precursor in hereditary coprocessors and present the clinical features.

TL;DR: Urinary 24-h MNt excretion level is the best single biochemical test for screening and, in combination with norephinephrine, is diagnostic of the presence of pheochromocytoma.

TL;DR: In this paper, a simple PEG precipitation assay for macroprolactin for use with the Bayer Immuno 1 analyzer, and to compare the reactivity of macroprolpactin in commonly used automated prolactin assays.

TL;DR: Many techniques utilized to assay patient urine samples are unable to detect fragmentedalbumin and, hence, will severely underestimate albumin and protein excretion.

TL;DR: Through the use of this quality control program, the two DAIS core laboratories were able to maintain their lipid analyses within the limits of allowable total error that had been established for the study.

TL;DR: Probes with a Delta T(m) of 5 degrees C or more between the matched and mismatched state are desirably for genotyping and can be selected by using a priori calculations based on the thermodynamic nearest neighbor model.

TL;DR: The continuous development of new analytical tools for the biochemical evaluation of patients with suspected myocardial injury brings without doubt new challenges of careful technological evaluation, implementation, and standardization but it may also provide a unique opportunity to markedly enhance diagnostic performance in the clinical setting of acute coronary syndrome.

TL;DR: It is concluded that p53 antibodies tend to develop in patients with tumor p53 accumulation, but p 53 accumulation is neither sufficient nor necessary for the generation of the immune response.