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Showing papers in "Clinical Gastroenterology and Hepatology in 2016"


Journal ArticleDOI
TL;DR: Almost 13% of patients with HCC in the VA system do not appear to have cirrhosis, and NAFLD and metabolic syndrome are the main risk factors for H CC in the absence of Cirrhosis.

450 citations


Journal ArticleDOI
TL;DR: In a prospective study of patients with cirrhosis, the combination of body mass index and thigh muscle thickness (measured by ultrasound) can identify male and female patients with sarcopenia almost as well as cross-sectional imaging.

337 citations


Journal ArticleDOI
TL;DR: It is proposed that serum levels of 6-10 μg/mL for infliximab and 8-12 μg/ mL for adalimumab are required to achieve mucosal healing in 80%-90% of patients with IBD, and that this could be considered as a "therapeutic window."

306 citations


Journal ArticleDOI
TL;DR: On the basis of a systematic review and meta-analysis, biologic agents increase the risk of opportunistic infections in patients with IBD, but not therisk of serious infections.

289 citations


Journal ArticleDOI
TL;DR: A preliminary set of criteria that could be used to classify IBD disease severity is proposed and it is suggested that a disease severity classification should be developed and validated by an international group to develop a pragmatic means of identifying patients with severe disease.

278 citations


Journal ArticleDOI
TL;DR: A significant association between symptoms of depression or anxiety and clinical recurrence of inflammatory bowel disease is found and patients with IBD should be screened for clinically relevant levels of depression and anxiety and referred to psychologists or psychiatrists for further evaluation and treatment.

239 citations


Journal ArticleDOI
TL;DR: Weight loss and tobacco smoking cessation should be recommended to GERD patients who are obese and smoke, respectively and avoiding late evening meals and head-of-the-bed elevation is effective in nocturnal GERD.

233 citations


Journal ArticleDOI
TL;DR: PPI therapy induces clinicohistologic remission in half of patients with symptomatic esophageal eosinophilia, and this finding should be interpreted with caution because of poor-quality evidence, heterogeneity, and publication bias.

227 citations


Journal ArticleDOI
TL;DR: In a meta-analysis, MH is associated with long-term clinical remission, avoidance of colectomy, and corticosteroid-free clinical remission and is therefore appropriate goal of UC therapy.

223 citations


Journal ArticleDOI
TL;DR: Analysis of impedance pH data by calculating the PSPW index and the MNBI can increase the accuracy of diagnosis of patients with reflux disease, compared with pH-only data.

203 citations



Journal ArticleDOI
TL;DR: Endoscopic therapy of WON by using Lumen-apposing metal stents is safe and effective and creation of a large and sustained cystogastrostomy or cystoenterostomy tract is effective in the drainage and treatment of Won.


Journal ArticleDOI
TL;DR: Patients with IBS-D and depression have similar alterations in fecal microbiota; these might be related to the pathogenesis of these disorders.

Journal ArticleDOI
TL;DR: Based on an analysis of 272 patients, FMT is somewhat less effective in clearing recurrent CDI from patients with IBD compared with patients without IBD, regardless of immunosuppressive therapy.

Journal ArticleDOI
TL;DR: There is a significant difference in serum concentration of infliximab at week 6 of treatment between responders and nonresponders and early development of ATIs during induction therapy reduces the serum Concentrations and is associated with nonresponse to treatment.


Journal ArticleDOI
TL;DR: In a cohort of patients with Crohn's disease or UC who failed previous anti-tumor necrosis factor therapy, approximately one third of patients achieved steroid-free clinical remission after 14 weeks of induction therapy with vedolizumab.

Journal ArticleDOI
TL;DR: E US-BD and PTBD had similar levels of efficacy in patients with unresectable malignant distal biliary obstruction and inaccessible papilla based on rates of technical and functional success and QOL, however, EUS-BD produced fewer procedure-related adverse events and unscheduled re-interventions.

Journal ArticleDOI
TL;DR: In a large multicenter study, endoscopic management of large LSL by EMR was significantly more cost-effective than surgery and should be considered the first line of therapy for most patients with this disorder.


Journal ArticleDOI
TL;DR: A high proportion of patients with cirrhosis are readmitted to the hospital (often to a different hospital) within 30 or 90 days; encephalopathy is most strongly associated with readmission.

Journal ArticleDOI
TL;DR: In an analysis of data from real-life clinical practice, infliximab concentrations during the induction therapy with STMH in patients with UC are associated with short-term mucosal healing (STMH).


Journal ArticleDOI
TL;DR: It is found that physical activity reduces intrahepatic lipid content and markers of hepatocellular injury in patients with NAFLD and individuals with increasing body mass index are increasingly more likely to benefit from the intervention.

Journal ArticleDOI
TL;DR: Long-term use of PPIs (≥12 months) is associated with an increased risk of FGPs, and PPI therapy might also increase the risk of gastric cancer, but this association could be biased, because of the limited number of studies and possible confounding factors.

Journal ArticleDOI
TL;DR: The EREFS classification system can be used to identify individuals with EoE and used as an endoscopic outcome measure to follow their response to treatment, and histologic responders have significantly lower scores than nonresponders.

Journal ArticleDOI
TL;DR: The relative risk for adverse events from RFA is found to be about 4-fold higher with EMR than without; factors associated with these events should be discussed with patients before endoscopic eradication therapy.

Journal ArticleDOI
TL;DR: In a randomized, placebo-controlled trial, mirtazapine significantly improved early satiation, quality of life, gastrointestinal-specific anxiety, nutrient tolerance, and weight loss in patients with functional dyspepsia.

Journal ArticleDOI
TL;DR: Over the past 10 years, the prevalence of hospitalizations for diverticulitis increased and then plateaued, whereas that of diverticular bleeding decreased, which indicates different mechanisms of pathogenesis for these disorders.