Showing papers in "Clinical Gastroenterology and Hepatology in 2016"
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TL;DR: Almost 13% of patients with HCC in the VA system do not appear to have cirrhosis, and NAFLD and metabolic syndrome are the main risk factors for H CC in the absence of Cirrhosis.
450 citations
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TL;DR: In a prospective study of patients with cirrhosis, the combination of body mass index and thigh muscle thickness (measured by ultrasound) can identify male and female patients with sarcopenia almost as well as cross-sectional imaging.
337 citations
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TL;DR: It is proposed that serum levels of 6-10 μg/mL for infliximab and 8-12 μg/ mL for adalimumab are required to achieve mucosal healing in 80%-90% of patients with IBD, and that this could be considered as a "therapeutic window."
306 citations
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TL;DR: On the basis of a systematic review and meta-analysis, biologic agents increase the risk of opportunistic infections in patients with IBD, but not therisk of serious infections.
289 citations
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TL;DR: A preliminary set of criteria that could be used to classify IBD disease severity is proposed and it is suggested that a disease severity classification should be developed and validated by an international group to develop a pragmatic means of identifying patients with severe disease.
278 citations
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Antonina Mikocka-Walus1, Antonina Mikocka-Walus2, Valérie Pittet3, Jean-Benoît Rossel3 +161 more•Institutions (4)
TL;DR: A significant association between symptoms of depression or anxiety and clinical recurrence of inflammatory bowel disease is found and patients with IBD should be screened for clinically relevant levels of depression and anxiety and referred to psychologists or psychiatrists for further evaluation and treatment.
239 citations
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TL;DR: Weight loss and tobacco smoking cessation should be recommended to GERD patients who are obese and smoke, respectively and avoiding late evening meals and head-of-the-bed elevation is effective in nocturnal GERD.
233 citations
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TL;DR: PPI therapy induces clinicohistologic remission in half of patients with symptomatic esophageal eosinophilia, and this finding should be interpreted with caution because of poor-quality evidence, heterogeneity, and publication bias.
227 citations
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TL;DR: In a meta-analysis, MH is associated with long-term clinical remission, avoidance of colectomy, and corticosteroid-free clinical remission and is therefore appropriate goal of UC therapy.
223 citations
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TL;DR: Analysis of impedance pH data by calculating the PSPW index and the MNBI can increase the accuracy of diagnosis of patients with reflux disease, compared with pH-only data.
203 citations
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TL;DR: Based on a retrospective analysis of patients admitted to Dutch hospitals, a first episode of acute pancreatitis leads to recurrent pancreatitis in 17% of patients, and almost 8% of Patients progress to CP within 5 years.
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Cornell University1, Johns Hopkins University2, University of Chicago3, Ochsner Health System4, University of Maryland, Baltimore5, Mount Sinai Hospital6, Stanford University7, Harvard University8, North Shore-LIJ Health System9, Columbia University Medical Center10, University of Missouri–Kansas City11, Thomas Jefferson University12
TL;DR: Endoscopic therapy of WON by using Lumen-apposing metal stents is safe and effective and creation of a large and sustained cystogastrostomy or cystoenterostomy tract is effective in the drainage and treatment of Won.
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TL;DR: The performance of the GALAD and BALAD-2 models for the diagnosis of HCC and predicting patient survival, respectively are validated in an international cohort of patients and might be used in HCC surveillance and determination of patient prognosis.
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TL;DR: Patients with IBS-D and depression have similar alterations in fecal microbiota; these might be related to the pathogenesis of these disorders.
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TL;DR: Based on an analysis of 272 patients, FMT is somewhat less effective in clearing recurrent CDI from patients with IBD compared with patients without IBD, regardless of immunosuppressive therapy.
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TL;DR: There is a significant difference in serum concentration of infliximab at week 6 of treatment between responders and nonresponders and early development of ATIs during induction therapy reduces the serum Concentrations and is associated with nonresponse to treatment.
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Washington University in St. Louis1, University of Southern California2, Mayo Clinic3, University of California, San Diego4, University of Pittsburgh5, Gundersen Health System6, University of Rochester7, University of Washington8, Ohio State University9, University of Amsterdam10, Abbott Northwestern Hospital11
TL;DR: Augmentation of the lower esophageal sphincter with a magnetic device provides significant and sustained control of reflux, with minimal side effects or complications, and validate the long-term safety and efficacy of the magnetic spHincter augmentation device for patients with GERD.
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Aix-Marseille University1, Centre Hospitalier Universitaire de Nice2, Paris Diderot University3, Claude Bernard University Lyon 14, University of Rouen5, Centre national de la recherche scientifique6, University of Rennes7, University of Nice Sophia Antipolis8, Lille University of Science and Technology9, French Institute of Health and Medical Research10, HCL Technologies11
TL;DR: In a cohort of patients with Crohn's disease or UC who failed previous anti-tumor necrosis factor therapy, approximately one third of patients achieved steroid-free clinical remission after 14 weeks of induction therapy with vedolizumab.
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TL;DR: E US-BD and PTBD had similar levels of efficacy in patients with unresectable malignant distal biliary obstruction and inaccessible papilla based on rates of technical and functional success and QOL, however, EUS-BD produced fewer procedure-related adverse events and unscheduled re-interventions.
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TL;DR: In a large multicenter study, endoscopic management of large LSL by EMR was significantly more cost-effective than surgery and should be considered the first line of therapy for most patients with this disorder.
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TL;DR: Almost two-thirds of patients with CD refractory to at least 1 anti-TNF agent receive clinical benefit from ustekinumab therapy, not requiring steroids for up to 12 months afterward.
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TL;DR: A high proportion of patients with cirrhosis are readmitted to the hospital (often to a different hospital) within 30 or 90 days; encephalopathy is most strongly associated with readmission.
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TL;DR: In an analysis of data from real-life clinical practice, infliximab concentrations during the induction therapy with STMH in patients with UC are associated with short-term mucosal healing (STMH).
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TL;DR: MCE detects focal lesions in the upper and lower stomach with comparable accuracy with conventional gastroscopy, and can be used to screen gastric diseases without sedation.
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TL;DR: It is found that physical activity reduces intrahepatic lipid content and markers of hepatocellular injury in patients with NAFLD and individuals with increasing body mass index are increasingly more likely to benefit from the intervention.
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TL;DR: Long-term use of PPIs (≥12 months) is associated with an increased risk of FGPs, and PPI therapy might also increase the risk of gastric cancer, but this association could be biased, because of the limited number of studies and possible confounding factors.
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TL;DR: The EREFS classification system can be used to identify individuals with EoE and used as an endoscopic outcome measure to follow their response to treatment, and histologic responders have significantly lower scores than nonresponders.
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TL;DR: The relative risk for adverse events from RFA is found to be about 4-fold higher with EMR than without; factors associated with these events should be discussed with patients before endoscopic eradication therapy.
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TL;DR: In a randomized, placebo-controlled trial, mirtazapine significantly improved early satiation, quality of life, gastrointestinal-specific anxiety, nutrient tolerance, and weight loss in patients with functional dyspepsia.
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TL;DR: Over the past 10 years, the prevalence of hospitalizations for diverticulitis increased and then plateaued, whereas that of diverticular bleeding decreased, which indicates different mechanisms of pathogenesis for these disorders.