Showing papers in "Clinical Therapeutics in 2005"

TL;DR: Capecitabine has shown varying degrees of efficacy with acceptable tolerability in numerous cancers including prostate, renal cell, ovarian, and pancreatic, with the largest amount of evidence in metastatic breast and colorectal cancer.

TL;DR: The Bone Quality Framework is presented in this paper as a means of summarizing and explaining the determinants of bone strength, and can be understood as an umbrella term that describes the set of characteristics that influence bone strength and explains the interrelationships of these characteristics.

TL;DR: Herbal and natural supplement use was widespread in the US adult population in 2002, according to data from the NHIS CAM survey, despite the fact that few participants informed their conventional health care providers about such use.

TL;DR: Although more head-to-head clinical trials are needed for a direct comparison of AE frequency, these preliminary data from separate reports suggest the possibility that AEs may be less likely with doxycycline than minocycline.

TL;DR: The role of immunohistochemistry for EGFR expression continues to be a poor predictor of patients who may benefit from cetuximab, which has shown considerable activity-both as monotherapy and in combination with chemotherapy-in the treatment of metastatic colorectal cancer that is resistant to chemotherapy.

TL;DR: The 3 formulations-bupropion, bupropion SR, and buPropion XL-are bioequivalent and offer options to optimize treatment for patients with MDD.

TL;DR: Adherence with antihyperglycemic pharmacotherapy was poor among working-aged patients newly treated for type 2 diabetes, and patients prescribed insulin as initial pharmacotherapy were less likely to persist on medication than those initially prescribed oral agents.

TL;DR: The MTM program showed that drug therapy for ambulatory patients taking multiple medications to treat chronic conditions can be improved through collaboration between physicians and community pharmacists.

TL;DR: All components of the glucose triad (ie, FPG, HbA1c, and PPG) should be considered in the management of type 2 diabetes.

TL;DR: RBX treatment appeared to be of benefit for the subgroup of patients with less severe symptomatic DPN by relieving sensory symptoms and improving nerve fiber function, as indicated by reductions in VDT and NTSS-6 total score.

TL;DR: The NTSS-6 provided a valid assessment of neuropathy sensory symptoms in this sample of patients with DM and DPN, which suggests that it may be useful for symptom evaluation in clinical trials and practice.

TL;DR: It is proposed that schizophrenia is associated with strongly interconnected abnormalities of glutamate and dopamine transmission: NMDA hypofunction in the prefrontal cortex and its connections might generate a pattern of dysregulation of dopamine systems that, in turn, further weakens NMDA-mediated connectivity and plasticity.

TL;DR: When considering treatment choices for patients with OAB, particularly the elderly, the potential CNS adverse effects of each anticholinergic agent must be weighed against the severity of OAB symptoms.

TL;DR: The combination of acamprosate and naltrexone appears to be more efficacious than acampingrosate alone, when combined with psychosocial interventions, and its efficacy is similar to nALTrexone.

TL;DR: A noncomparative, open-label study in adult patients with type I GD who were unwilling or unable to receive enzyme replacement therapy (ERT) or who had discontinued ERT for at least 3 months to evaluate the tolerability and safety profile of miglustat.

TL;DR: Use of pramlintide in addition to insulin in patients with type 1 and type 2 diabetes was associated with modest reductions in HbA(1c) and the incidence of hypoglycemia in the first 4 weeks of therapy was 2 to 4 times greater with pramsintide compared with placebo; thus, the manufacturer recommends reducing the dose of premeal insulin by 50% when starting pramlintide.

TL;DR: Insulin pen devices are discreet and offer patients convenience and flexibility, which may give patients the confidence to overcome issues of needle anxiety and the social embarrassment associated with self-injection and, therefore, may lead to improved adherence to recommended insulin dosing schedules and compliance with multiple- injection regimens.

TL;DR: The goal of this article was to review and synthesize the published clinical evidence for the management of pain caused by invasive procedures in preterm and full-term neonates and identify research priorities in this area.

TL;DR: Tinidazole appears to be a promising agent for the treatment of trichomoniasis, giardiasis, amebiasis, and amebic liver abscess and no data were found on the disposition of tinidazoles in patients with hepatic insufficiency; therefore, use of tinodazole in Patients with severe hepatic impairment (Child-Pugh class C) is not recommended.

TL;DR: The findings of a meta-analysis suggest that there are insufficient data to justify use of IV midazolam for sedation in ventilated neonates, and well-designed and adequately powered clinical trials are needed to establish the safety, efficacy, and short- and long-term outcomes of analgesia and Sedation in the mechanically ventilated newborn.

TL;DR: Pemetrexed is a multitargeted antifolate that has demonstrated antitumor activity in various tumor types as a single agent and in combination with other chemotherapeutic agents and its current and potential roles in therapy for MPM, NSCLC, and other oncologic conditions.

TL;DR: The findings suggest that the use of anti-oxidants may have decreased oxidative stress in patients with early-stage, untreated type 2 diabetes mellitus and those with IGT, but these postprandial changes were reverse in all subjects after 15 days of standard antioxidant supplementation.

TL;DR: In this preliminary trial, an adherence clinic model improved adherence to HAART and virologic response over 28 weeks in the patients studied.

TL;DR: Evaluated patients diagnosed as having schizophrenia or bipolar disorder with prescribed oral atypical and conventional antipsychotic agents and the corresponding impact on resource utilization found partial compliance was associated with an increased risk of hospitalization and switching or augmentation of therapy when compared with being compliant.

TL;DR: The fact that this retrospective analysis conducted in identical cohorts showed lower calculated equipotent oral morphine doses in the buprenorphine TD groups compared with the fentanyl TD groups calls into question the proposed 1:75 ratio for conversion of bupreliminary data from prospective randomized clinical trials are needed.

TL;DR: 24 weeks of treatment with muraglitazar 2.5 or 5 mg was an effective treatment option for these patients with type 2 diabetes whose disease was inadequately controlled with diet and exercise.

TL;DR: The analysis suggests that the association between compliance and age or gender may be quite stable over the first 3 years of treatment, and risk factors of treatment discontinuation, treatment resumption, and adherence were remarkably similar and were stable over time.

TL;DR: Erlotinib is an oral tyrosine kinase inhibitor, 1026 targeting the human epidermal receptor type 1/epidermal growth factor receptor, recently approved by the US Food and Drug Administration (FDA) for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) after the failure of more than 1 or 2 previous chemotherapeutic regimens as mentioned in this paper.

TL;DR: In this study of patients with type 2DM, SC administration of exenatide into the abdomen, arm, or thigh resulted in comparable bioavailability, and intrasubject variability of AUC(0-infinity) was low among the 3 treatments.

TL;DR: There is a minimum daily amount of maintenance therapy necessary to prevent exacerbations in adults with persistent asthma, and stable dosing of SAL/FP resulted in significantly greater increases in symptom-free days, days free of rescue medication, and morning PEE, as well as almost halving the exacerbation rate.