Showing papers in "Colloids and Surfaces B: Biointerfaces in 2016"

TL;DR: Preparation, application and characterization of polymeric based nano-capsules and natural nano-carriers for phenolics, and future investigations could focus on application of phenolic nano-scale delivery systems in pharmaceuticals and functional foods.

TL;DR: Metal and metal oxide nanoparticles including silver and zinc oxide exhibit remarkable antimicrobial activities against pathogens and hence are one of the most propitious alternative antimicrobial agents.

TL;DR: This work fabricated three kinds of polylactic acid (PLA) carriers including microspheres, microcapsule, and porous microcapsules for controlled delivery of Lambda-Cyhalothrin (LC) via premix membrane emulsification (PME), showing a significantly sustained release of LC for a longer period.

TL;DR: Combinational therapy using conventional chemotherapeutic drug and cancer stem cell inhibitor could be a promising approach in overcoming cancer recurrence due to resistant cell population.

TL;DR: This work synthesized HNT-Cur prodrug with a controlled curcumin release on dependence of both intracellular glutathione (GSH) and pH conditions and investigated the kinetics of curCumin release by UV-vis spectroscopy, which highlighted that HNT, Cur prodrug possesses dual stimuli-responsive ability upon exposure to GSH-rich or acidic environment.

TL;DR: The uptake of immune nanoparticles with a controlled delivery of the peptide iAβ5 was substantially increased compared to the nanoparticles (NPs) without monoclonal antibody functionalization.

TL;DR: The findings reported here indicate that TMC-g-PA SLRNs represent a potential oral drug delivery system for resveratrol.

TL;DR: The cost-efficient tilapia collagen nanofibers could be used as novel wound dressing, meanwhile effectively avoiding the risk of transmitting animal disease in the future clinical apllication and could accelerate rat wound healing rapidly and effectively.

TL;DR: MUC1-aptamer targeted Au@SPIONs could serve as promising theranostic agents for simultaneous MR imaging and photothermal therapy of cancer cells and they could be exploited as contrast agents.

TL;DR: A family of medicated Janus fibers that provides highly tunable biphasic drug release was fabricated using a side-by-side electrospinning process employing a Teflon-coated parallel spinneret to offer the potential to rationally design systems with highly controllable drug release profiles, which can complement natural biological rhythms and deliver maximum therapeutic effects.

TL;DR: This work modified a previously studied CAMP sequence, in order to increase or diminish the hydrophobic face, changing the position of two lysines or replacing three leucines, respectively, and allowed us to study the importance of this parameter in the membrane interactions of the peptides.

TL;DR: Low silver concentrations were required for effective enhancement of antibacterial activity against multiresistant bacteria, and these low silver concentrations showed no cytotoxic effect towards mammalian cells, an important feature for potential medical applications.

TL;DR: This work proves that magnetoelectric Terfenol-D/poly(vinylidene fluoride-co-trifluoroethylene) composites are able to provide mechanical and electrical stimuli to MC3T3-E1 pre-osteoblast cells and that those stimuli can be remotely triggered by an applied magnetic field.

TL;DR: In this article, the authors used aqueous leaf extract of A. obesum (AOAgNPs) for the synthesis of silver nanoparticles, which were further characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and transmission electron microscopy (TEM).

TL;DR: Tuning morphological features of nanostructures on micro-topography can serve as a promising strategy to specifically modulate cellular response, such as cell morphology, proliferation, differentiation and mineralization.

TL;DR: AmB-UDL provided a profound AmB penetration toward deep epithelial layers, achieved without classical permeation enhancers, and may be regarded of potential of clinical significance in topical treatments of cutaneous fungal infection and leishmaniasis.

TL;DR: In this paper, a protocol for keeping E. coli cells swimming at constant speed at finite bulk concentrations is proposed, using motility as a high-throughput probe of aspects of cellular physiology via the coupling between swimming speed and the proton motive force.

TL;DR: The results indicated that the hybrid system facilitated FK506 ocular delivery on mucoadhesion, precorneal retention, aqueous humor pharmacokinetics and transcorneal permeability, and indicated that HA-coated niosomes may be a promising approach for ocular targeting delivery of Fk506.

TL;DR: The results indicates that TiO2 and ZnO nanoparticle inhibits Salmonella, Klebsiella and Shigella, and it was proved that Ti o2 andZn o nanoparticle are biocompatible materials.

TL;DR: Investigation of the effects of PLGA-functionalized quercetin (PLGA@QT) NPs on inhibited and disassembled Aβ42 fibrils and the results from behavioral tests indicate that injections into APP/PS1 mice ameliorate cognition and memory impairments and provide substantial evidence of the safety of PL GA@Qt NPs for biomedical application.

TL;DR: In this article, the authors developed mixed micelles based on two biocompatible copolymers of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus(®)) and D-α-tocopheryl polyethylene-glycol 1000 succinate (TPGS), to improve the aqueous solubility and the in vitro anti-tumor activity of paclitaxel (PTX).

TL;DR: HA-SH hydrogels with controllable gelation process, intelligent degradation behavior, excellent biocompatibility and convenient operational characteristics supplied potential clinical application capacity for tissue engineering and regenerative medicine.

TL;DR: It is shown that encapsulating resveratrol in colloidal mesoporous silica nanoparticles (MCM-48-RES) enhances its saturated solubility by ∼95% and increases its in vitro release kinetics compared to pure resver atrol.

TL;DR: SPION-Dtxl exhibited potent anti-cancer efficacy via induction of the expression of apoptosis associated proteins, downregulation of anti-apoptotic proteins, and inhibition of chemo-resistance associated protein in PC cell lines, suggesting that a PSMA antibody functionalized SPION- Dtxl formulation can be highly useful for targeted PC therapy.

TL;DR: Results indicated that coating with cross-linked polymers could significantly improve the physicochemical properties of SLNs and expand their potentials as oral delivery systems for lipophilic nutrients and drugs.

TL;DR: The purpose of this study is to develop and characterize a co-loaded paclitaxel and rapamycin liposome and evaluate it for breast cancer efficacy both in vitro and in vivo, and it is expected that the formulation developed herein might be a contribution for future studies focusing on the clinical combination of paclitrixel andRapamycin.

TL;DR: Both batches of nanospheres developed are confirmed to be effective to treat and prevent ocular inflammation and to be less cytotoxic than free dexibuprofen in the majority of the tested concentrations.

TL;DR: Nanograting-induced cell polarity and cytoplasmic YAP localization were shown to be critical to the induced neural differentiation of hiPSCs, indicating the existence of multiple neuronal subtypes.

TL;DR: It is demonstrated that the poly(PCL/PDMS urethane)/carbon-black nanofibers with shape memory properties could be potentially used as smart 4-dimensional scaffolds for nerve tissue regeneration.

TL;DR: Mechanism of the observed cytotoxicity of AIGNPs was explained on the basis of increased levels of reactive oxygen species and simultaneous reduction in cellular antioxidants, which might have caused mitochondrial membrane potential loss, DNA damage and G1/S phase cell cycle arrest.