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Showing papers in "Computer Methods and Programs in Biomedicine in 2008"


Journal ArticleDOI
TL;DR: This article presents an international selection of leading smart home projects, as well as the associated technologies of wearable/implantable monitoring systems and assistive robotics, often designed as components of the larger smart home environment.

935 citations


Journal ArticleDOI
TL;DR: An add-on package for the open source statistical package R, designed to compute normalised prediction distribution errors (npde), which takes into account the full predictive distribution of each individual observation and handle multiple observations within subjects.

377 citations


Journal ArticleDOI
TL;DR: Some records of ECG signals in MIT-BIH arrhythmia database are tested to show the proposed Difference Operation Method (DOM) has a much more precise detection rate and faster speed than other methods.

268 citations


Journal ArticleDOI
TL;DR: The validated stochastic model and methods provide a platform for developing advanced glycemic control methods addressing critical care variability, and adaptive control method incorporating S(I) variability is shown to produce improved gly glucose control in simulated trials compared to current clinical results.

152 citations


Journal ArticleDOI
TL;DR: The proposed classifier is a modified probabilistic neural network (PNN), incorporating a non-linear least squares features transformation (LSFT) into the PNN classifier, improved PNN performance, increased class separability and resulted in dimensionality reduction.

128 citations


Journal ArticleDOI
TL;DR: SAS macros and R functions are presented to compute pseudo-values of the survival function, the restricted mean and cumulative incidence function with right censored data and how to obtain regression estimates for a study of bone marrow transplant patients is illustrated.

119 citations


Journal ArticleDOI
TL;DR: A feed-forward backpropagating artificial neural network is used for the classification and genetic algorithm for choosing the training set and also implement a post-classification stage using harmonic weights to increase the accuracy.

110 citations


Journal ArticleDOI
TL;DR: A new technique for the real-time simulation of non-linear tissue behavior based on a model reduction technique known as proper orthogonal (POD) or Karhunen-Loève decompositions is introduced.

105 citations


Journal ArticleDOI
TL;DR: This work estimates the optimum PCA-based feature space by evaluating the algorithm's performance on simulated series of action potentials and introduces a new metric to define clustering error considering over-clustering more favorable than under-Clustering as proposed by experimentalists for data.

103 citations


Journal ArticleDOI
TL;DR: The effectiveness of 11 different feature sets in classification of voice recordings of the sustained phonation of the vowel sound /a/ into a healthy and two pathological classes, diffuse and nodular, is investigated.

99 citations


Journal ArticleDOI
TL;DR: Three emerging computer-aided diagnosis (CAD) systems induced by Japanese health care needs are described, regarding the development of CAD systems for the early detection of cerebrovascular diseases using brain MRI and MRA images by detecting lacunar infarcts, unruptured aneurysms, and arterial occlusions.

Journal ArticleDOI
TL;DR: The proposed protocol is simple, cost effective, repeatable and highly correlated to the gold-standard clamp, and designed with physiological dosing, short duration, simple protocol, low cost and high repeatability.

Journal ArticleDOI
TL;DR: BrightStat's goals, its main capabilities and functionalities are outlined, and the results obtained are compared with SPSS, one of the global leader in providing statistical software, and VassarStats, a collection of scripts for data analysis running on the Internet.

Journal ArticleDOI
TL;DR: In this study a new stochastic approximation is developed and applied to a unit of a teaching hospital and based on target levels of the control parameters, a profit and loss analysis is performed.

Journal ArticleDOI
TL;DR: A novel approach to view-based eye gaze tracking for human computer interface (HCI) is presented, which is able to classify the gaze direction of the user over a 15-zone graphical interface, comparable with the vast majority of existing remote gaze trackers.

Journal ArticleDOI
TL;DR: This paper presents the control system design of a rehabilitation and training robot for the upper limbs based on a hierarchical structure, which allows the execution of sequence of switching control laws corresponding to the required training configuration.

Journal ArticleDOI
TL;DR: An intelligent decision support system based on supervised classification by Bayesian classifiers to aid to the selection of the most promising embryos that will form the batch to be transferred to the woman's uterus is proposed.

Journal ArticleDOI
TL;DR: Comparisons of anthropometry and numerical simulations of a child head model based on medical CT scans to aChild head model developed by scaling an adult head model using the method proposed by Mertz point out significant differences showing that scaling down an adultHead to obtain a childHead does not appear relevant.

Journal ArticleDOI
TL;DR: The experiments prove that the combination of MI-based feature selection and SVM techniques outperforms other commonly used combination, for example, the PCA and NN and superior performance of the proposed classification scheme illustrates the potential of the S VM techniques combined with WPT and MI in EMG motion classification.

Journal ArticleDOI
TL;DR: A fast algorithm is proposed which speeds up the computation of approximate entropy by detecting early some vectors that are not similar and by excluding them from the similarity test.

Journal ArticleDOI
TL;DR: A hybrid RISP (RNA-interaction site prediction) method, using support vector machine (SVM) in conjunction with evolutionary information of amino acid sequences in terms of their position-specific scoring matrices (PSSMs) for prediction of RNA-binding sites.

Journal ArticleDOI
TL;DR: To train and validate artificial neural networks (ANN), using clinical and pharmacogenetic data, to predict clozapine response in schizophrenic patients, the optimal ANN architecture was found to be a standard feed-forward, fully-connected, back-propagation multilayer perceptron.

Journal ArticleDOI
TL;DR: The alternative approach of using a remote analysis server which does not enable any data release, but instead is designed to deliver useful results of user-specified statistical analyses with a low risk of disclosure is discussed.

Journal ArticleDOI
TL;DR: Simulation results suggest that a variant of the Wodarz and Nowak mathematical model adding "aggressiveness" as a new state variable in order to quantify the strength of the virus and its response to drugs may be useful in predicting the impact of the effectiveness of therapy on HIV dynamics.

Journal ArticleDOI
TL;DR: Overall, stress decreased at the supporting tissues as mucosa thickness and resiliency increased, and the use of bar-clip attachment system with distally placed o'ring attachment design optimized the stress distribution.

Journal ArticleDOI
TL;DR: Assessment of the ability of multilayer perceptron (MLP) neural networks as an assistant tool in the diagnosis of the obstructive sleep apnoea syndrome (OSAS) found them to represent a useful technique for OSAS detection.

Journal ArticleDOI
TL;DR: This paper describes the development of the CARDSS system and technical issues are discussed concerning the delivery of active decision support, and the provision of advice rationales to users while taking account of dynamic clinical contexts and changing guidelines.

Journal ArticleDOI
TL;DR: An extended model for image segmentation based on artificial ant colonies, where each ant can memorize a reference object, which will be refreshed when it finds a new target.

Journal ArticleDOI
TL;DR: A new algorithm that analyzes the nasal airflow (NAF) for the detection of obstructive apneic events based on mean magnitude of the second derivatives (MMSD) of NAF, which can detect respiration strength robustly under offset or baseline drift is introduced.