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Showing papers in "Computers and Biomedical Research in 1983"


Journal ArticleDOI
TL;DR: In this paper a new robust single lead QRS-detection algorithm is presented, allowing real-time applications and results are presented.

101 citations


Journal ArticleDOI
TL;DR: A system of programs for building three-dimensional models of biological structures was developed and it is possible to obtain further anatomical data by counting and mapping silver grains in autoradiographs of tissue sections.

53 citations


Journal ArticleDOI
TL;DR: The effect of assuming independence in the use of Bayes' Theorem for classification and estimation of risk is examined and results in classification error rates comparable or better than rates obtained by using the correct model.

48 citations


Journal ArticleDOI
TL;DR: An original experience which entails potential solutions of these issues is reported on: the task of knowledge engineering is performed by residents and medical students on a psychiatry ward, and a computer program for the psychopharmacological treatment of depression is developed using a sophisticated knowledge acquisition system, EMYCIN.

39 citations


Journal ArticleDOI
TL;DR: A computer graphics system is described which reconstructs three-dimensional images from serial sectional data, very simple to operate and yet flexible enough to allow selective portions of the tissue sample to be reconstructed and displayed in various orientations.

34 citations


Journal ArticleDOI
TL;DR: A discrete computer model simulating the operation of the cardiac impulse transmission apparatus and the electropotential changes of the heart musculature has been developed on a NORD-100 minicomputer and the principles on which the model is based are described and the paper shows concisely several examples in the form of simulated ECG records.

33 citations


Journal ArticleDOI
TL;DR: A method for quantitative evaluation of diadochokinesia test (alternate pronation and supination of forearms) has been developed and a summarized measure for regularity agreed very well with visual judgment.

29 citations


Journal ArticleDOI
TL;DR: A method has been developed, employing sinusoidal forcing, to determine intra-breath variations of respiratory impedance, which can yield impedances which are accurate to within 5% in magnitude, and 5 degrees in phase angle at all instants within the breath.

26 citations


Journal ArticleDOI
TL;DR: The program generalizes most aspects of a previously published program on trend and homogeneity analyses of proportions and life table data and may prove helpful for case-control studies, clinical trials, and combining animal studies.

24 citations


Journal ArticleDOI
TL;DR: An advanced microprocessor-based LACN using fiberoptic communications has been developed by the Applied Physics Laboratory of The Johns Hopkins University and has been implemented at the University of California, San Francisco Hospital.

24 citations


Journal ArticleDOI
TL;DR: The analysis of data variously termed growth curve data, repeated measurements data, or profile data is discussed, which finds that a low degree polynomial can be fitted to the profile of measurements for each experimental unit, thereby reducing the dimension of the profile considerably.

Journal ArticleDOI
TL;DR: The article describes the purposes and contents of all different lessons of this course, which contains lessons in the areas of medical data bases, hospital information systems, medical records, biological signal analysis, computer-assisted diagnosis making, and patient simulation by CAI.

Journal ArticleDOI
TL;DR: The article develops a general formula for weighting exposures and describes the cumulative index, the lag, partial weight, and the lognormal models as specific examples.

Journal ArticleDOI
TL;DR: A graphic computer based system for coronary angiographic reporting and data storage that uses a multisegmental model of the coronary tree so that precise localization of coronary lesions can be made in relation to major branches is developed.

Journal ArticleDOI
TL;DR: A rule-based computer system was developed to perform clinical decision-making support within a medical information system, oncology practice, and clinical research that possesses features of generalizability, modularity of structure, convenience in rule acquisition, explanability, and utility for patient care and teaching.

Journal ArticleDOI
TL;DR: A new tool for implementing pattern recognition algorithms that learn by observation, the pattern recognition language SEEK, is described: programs written in SEEK build a knowledge base containing treelike data structures, each of which stores acquired information about a particular multichannel waveform.

Journal ArticleDOI
TL;DR: The Fujihara model is indicated to be much more likely to be justified when optimal sinusoids are used to generate the data than when Casaburi's arbitrary frequencies are used, suggesting that more descriptive models of respiratory control may be developed with the aid of optimal frequency design for the input sinusoid.

Journal ArticleDOI
TL;DR: Bone marrow smears stained with Giemsa were scanned with a video camera under computer control and two types of features were extracted: form features, e.g., area and length, and gray level features, which identified the points of steepest gray level change in the cell.


Journal ArticleDOI
TL;DR: The volume of the rat myocardial extracellular compartment was determined by electronic image analysis and compared with values obtained by point-counting on the same histological micrographs and the subjective component of the morphometry was not entirely eliminated.

Journal ArticleDOI
TL;DR: Image processing algorithms useful for the optical monitoring of eye movements have been developed and evaluated and results indicate that straightforward algorithms implemented with relatively slow microcomputers can yield sample rates well in excess of standard TV field rates.

Journal ArticleDOI
TL;DR: Reversed-phase high performance liquid chromatography and multivariate discriminant analysis are used for the classification of acute and chronic leukemias and the preprocessing techniques of autoscaling and variance weighting minimized inadvertent weighting and reduced the contribution of nondescriptive data components in the development of the discriminant function.

Journal ArticleDOI
TL;DR: The computer simulation model, calibrated and verified with in-house data sets, is a reliable, cost-effective and flexible tool for dialysis system investigations, prediction, and optimal design.

Journal ArticleDOI
TL;DR: A microcomputer program is presented which stores and retrieves qualitative patient information, such as diagnosis and physical findings, and users can design and enter a key word list and modify it as needed.

Journal ArticleDOI
TL;DR: A simple program written in Microsoft BASIC for the analysis of radioimmunoassay data is presented and finds its greatest use in research laboratories where a number of different RIA are performed and where it is of value to have some control over the computation process.


Journal ArticleDOI
TL;DR: Computer image analysis programs developed by astronomers for celestial photometry were used for the analysis of autoradiographs of electrophoretic slab gels to study oxytocin-stimulated myosin light chain phosphorylation in mammary myoepithelial cells.

Journal ArticleDOI
TL;DR: It is shown how this procedure can be used to obtain the exact confidence limits for a standardized mortality ratio, a parameter of great interest to epidemiologists.

Journal ArticleDOI
TL;DR: An on-line data acquisition system for external beam treatment planning has been developed and the beam data format consists of a set of percentage depth doses along the central axis and five sets of off-axis ratios at five different depths.

Journal ArticleDOI
TL;DR: It is concluded that care must be taken in the identification of patients using radionuclide angiography who have normal and abnormal left ventricular function; it can be done with confidence only when linear fits with contrast ventriculographic results have high correlation coefficients.