Showing papers in "Current Biology in 1993"

TL;DR: Peptide-mass fingerprints can prove as discriminating as linear peptide sequences, but can be obtained in a fraction of the time using less protein, which allows for a rapid identification of a sample protein before committing it to protein sequence analysis.

TL;DR: The design of two peptides that are predominantly unfolded in isolation but which, when mixed, associate preferentially to form a stable, parallel, coiled-coil heterodimer show that it is possible to design peptides with simple sequences that have a very high preference to pair with one another.

TL;DR: The Florida panther has recently suffered severe range and demographic contraction, leaving a remarkably low level of genetic diversity, manifested by spermatozoal defects, cryptorchidism, cardiac abnormalities and infectious diseases that threaten the survival of the subspecies.

TL;DR: The results strongly suggest that oligodendrocyte survival depends upon the presence of axons and support the hypothesis that a competition for axon-dependent survival signals normally helps adjust the number of oligodendedrocytes to the numberof axons that require myelination.

TL;DR: The observed rearrangement is consistent with an inward 5-10 degrees rotation of subunits, pivoting about the subunit contacts between the two heptamers, and thus bringing cpn60 domains towards the position occupied by the bound polypeptide.

TL;DR: A new tool that is developed to perform rapid structural alignment can help to identify structurally similar folds rapidly and with high-sensitivity, providing a powerful tool for analyzing the ever-increasing number of protein structures being elucidated.

TL;DR: It is shown that manipulating the expression of a single hsp can be sufficient to improve the stress tolerance of a complex multicellular organism, and also that the role of the 70 kD heat-shock protein, Hsp 70, in thermotolerance is investigated.

TL;DR: It is demonstrated that, by intermolecular recombination, this simple and efficient technique is well suited to cell-lineage analysis and can be easily extended to the generation and detection of mutant clones in mosaic animals.

TL;DR: It is proposed that sds22 is a regulatory subunit of the dis2/sds21 phosphatase catalytic subunits and that sDS22-bound phosphatases carries a key phosphat enzyme activity essential for the progression from metaphase to anaphase.

TL;DR: Nitric oxide may mediate the release of acetylcholine and dopamine in response to K(+)-depolarization in PC-12 cells and the release to N-methyl-d-aspartate in striatal synaptosomes.

TL;DR: Cells within the muscle progenitor region of a Xenopus embryo need to interact with each other in order to activate muscle genes in homogeneous cell groups, which exemplifies the 'community effect', which may be a widespread developmental mechanism used to increase the homogeneity within, and demarkation between, embryonic tissues.

TL;DR: It is shown that the presence of cytoplasmic regions containing the ARM motif from either Ig-alpha or Ig-beta is sufficient to confer signalling capability on an otherwise non-functional fusion protein.

TL;DR: Features of the organization of the cat brain, together with earlier primate results, suggest that there may be a common cortical plan in mammals and this common plan may involve relatively discrete, hierarchically organized, cortical sensory systems and a topologically central fronto-limbic complex.

TL;DR: All the homeotic genes that specify middle body regions in insects originated before the divergence of the insect and crustacean lineages, probably not later than the Cambrian (about 500 million years ago).

TL;DR: For a set of helical proteins that have simple native topologies, the native folds of the proteins can be predicted with reasonable accuracy from their sequences alone.

TL;DR: A growing body of evidence supports the view that the localization depends on specific sequence elements-which the authors call 'zipcodes' by analogy to a system in which a message can be addressed to a specific postal zone with a minimum of coding information-that occur generally within the 3' untranslated region (UTR) of the mRNAs.

TL;DR: Ch chromatid BFB cycles are a major source of both 'intrachromosomal' gene amplification and genomic rearrangement, which are first limited to a single chromosome but which can then potentially spread to any additional chromosome.

TL;DR: Comparison of over 100 peptides reveals the importance of the carboxy-terminal residue in selective binding of major histocompatibility complex peptides.

TL;DR: The findings suggest that viral transmembrane proteins can mimic the antigen-induced stimulation of the B-cell antigen receptor and thus can influence the activation and/or survival of infected B lymphocytes.

TL;DR: The data indicate that assortative recombination occurs frequently within populations, but not between populations, and the sequences of two house-keeping genes show no evidence of intragenic recombination between N. gonorrhoeae and N. meningitidis.

TL;DR: It is taken for granted nowadays that extracellular signals are amplified and transduced inside cells by protein kinase cascades, but relatively little was known about how all these different protein kinases are orchestrated within signalling pathways.

TL;DR: In vitro evolution experiments make it possible to elucidate important aspects of both evolutionary biology and structural biochemistry on a reasonable short time scale and infer how certain mutations influence the catalytic properties of the ribozyme.

TL;DR: The hematopoietins constitute a family of structurally related proteins that includes many cytokines, growth factors and hormones that are proposed to be classified based on their size, gene organization and sequences.