Showing papers in "Current Biology in 1995"

TL;DR: The results suggest that IT neurons can develop a complex receptive field organization as a consequence of extensive training in the discrimination and recognition of objects, and support the idea that a population of neurons tuned to a different object aspect, and each showing a certain degree of invariance to image transformations--may encode at least some types of complex three-dimensional objects.

TL;DR: Evidence is presented that the calibration of grasp is quite refractory to pictorial illusions that have large effects on perceptual judgements of size, suggesting that the automatic and metrically accurate calibrations required for skilled actions are mediated by visual processes that are separate from those mediating the authors' conscious experiential perception.

TL;DR: This work has shown that transcription factors are kept in a latent state in the cytoplasm and are translocated into the nucleus upon activation, where they phosphorylate target transcription factors.

TL;DR: The genomes of six major grass species can be aligned by dissecting the individual chromosomes into segments and rearranging these linkage blocks into highly similar structures.

TL;DR: It is suggested that secreted signals encoded by members of the hedgehog gene family, emanating from the ventral midline of the neural tube, not only play important roles in dorso-ventral patterning of the brain but also appear to constitute an early patterning activity along the proximo-distal axis of the developing eyes.

TL;DR: It is shown that platelet-derived growth factor can stimulate an increase in the level of GTP-Rac by at least two distinct mechanisms: firstly, by increased guanine nucleotide exchange; and secondly, by inhibition of a Rac GTPase activity.

TL;DR: GFP is an invaluable new tool for studies of molecular biology and cell physiology as a marker of transfection in vivo and provides a simple means of identifying genetically modified cells to be used in physiological studies.

TL;DR: It is shown that the transcription factor RBP-J kappa/Su(H) interacts directly with a novel intracellular domain of the cell-surface receptor Notch.

TL;DR: Importin 90 potentiates the effects of importin 60 on nuclear protein import, indicating that the importin complex is the physiological unit responsible for import.

TL;DR: It is shown that protein kinase C must first be processed by three distinct phosphorylations before it is competent to respond to second messengers, and the conservation of each of these residues in conventional, novel and atypical protein Kinase Cs underscores the essential role for each in regulating the protein kinases C family.

TL;DR: It is reported that a significant proportion of female p53-/- mice die during embryogenesis or in the period between birth and weaning, being subject to a spectrum of abnormalities.

TL;DR: The results provide the first expression mapping of these genes that distinguishes between progenitors in different commitment states, generate new insights and predictions relevant to mechanism, and introduce a powerful set of tools for unravelling the genetic basis of lineage divergence.

TL;DR: It is proposed that S-phase-promoting cyclin B--Cdk complexes prevent re-replication during S, G2 and M phases by inhibiting the transition of replication origins to a pre-replicative state.

TL;DR: The rapid inactivation of p42mapk initiated five minutes after stimulation of endothelial, adipose and chromaffin cells with growth factor, and was initiated by the major vanadate-sensitive Tyr 185-specific phosphatase, explaining why dephosphorylation of Thr 183 is rate-limiting for p42 mapk inactivation in PC12 cells after stimulation with EGF.

TL;DR: Evidence that a recently identified member of the fibroblast growth factor (FGF) family is expressed in the ectoderm of the prospective limb territory prior to morphological outgrowth of the limb bud in both mouse and chick indicates that FGF-8 is an AER-derived mitogen that stimulates limb bud outgrowth.

TL;DR: There is an excellent correlation between the ability of mutant Crk proteins to promote hyperphosphorylation of p130 by Abl and their ability to transform rodent fibroblasts and the substrate specificity of a non-receptor tyrosine kinase is dependent on the binding specificity of its associated SH2 domain.

TL;DR: PCNA and the cell-cycle regulator p21WAF1 interact in vivo, and it is shown that this interaction requires the central loop of PCNA and an eight amino-acid motif from the carboxyl terminus of p21 WAF1.

TL;DR: It is demonstrated that expression in Xenopus embryos of RNA encoding a dominant-negative FGF receptor inhibits the mesoderm-inducing activity of Xbra, and suggests that the two genes are components of a regulatory loop.

TL;DR: New insights have begun to emerge only recently on the normal function of these growth factors in mice and humans, as a result of studies of natural and experimental mutations in the factors and their receptors.

TL;DR: The structure of microtubules assembled in vitro was investigated, and it was found that their fine structure was sensitive to the presence of taxol, suggesting that a general mechanism may underlie the stabilization of micro tubules by different agents.

TL;DR: PCR-based analysis of mononucleotide repeats may be used to detect both intraspecific and interspecific variability in the chloroplast genomes of seed plants and provides an important experimental tool to examine a range of issues in plant genetics.

TL;DR: It is concluded that presence of the RPE is required for the normal development of the eye in vivo, and its presence early in development is necessary for the correct morphogenesis of the neural retina.

TL;DR: It is demonstrated that SHH is proteolytically processed in developing chick limbs and that of the two cleavage products resulting from SHH autoproteolysis, SHH-N expressed in grafted heterologous cells or supplied in purified form is sufficient to impose pattern upon the developing limb.

TL;DR: It is shown that the induction of vg, which initiates wing development in Drosophila, requires the combined activities of Ser, wg and Notch, and it is proposed that Ser is a dorsal signal and Wg is a ventral signal, and that their combination at the dorso-ventral interface activates the Notch receptor and leads to vg expression.

TL;DR: Elk-1 responds to stress-induced, as well as mitogenic, signals by stimulating c-fos transcription through the serum response element, and constitutes an additional mechanism by which cells can upregulate AP-1 activity in response to stress.

TL;DR: The discovery of a eubacterial proteasome show that the ubiquitin pathway of protein degradation is ancestral and common to all forms of life.

TL;DR: An in vitro assay which uncouples the notochord-mediated induction of motor neurons from floor plate differentiation and shows that Shh can initiate the differentiation of two cell types that are generated in the ventral region of the neural tube.

TL;DR: The molecular basis of the binding of these domains to their ligands has been revealed, making it possible to identify SH3-binding sites in new proteins.

TL;DR: Conventional protein kinase Cs have two conserved regulatory domains, C1 and C2, shared by many other membrane-interacting proteins.