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Showing papers in "Current Biology in 2004"


Journal ArticleDOI
TL;DR: It is found that the rictor-mTOR complex modulates the phosphorylation of Protein Kinase C alpha (PKCalpha) and the actin cytoskeleton, suggesting that this aspect of TOR signaling is conserved between yeast and mammals.

2,609 citations


Journal ArticleDOI
TL;DR: This study investigates spatial localization of audio-visual stimuli and finds that for severely blurred visual stimuli, the reverse holds: sound captures vision while for less blurred stimuli, neither sense dominates and perception follows the mean position.

1,642 citations


Journal ArticleDOI
TL;DR: Future studies will no doubt continue to identify the functional and biochemical properties of new chromatin domains as well as to elucidate the principles that govern their maintenance and propagation.

1,259 citations


Journal ArticleDOI
TL;DR: Investigating ‘chronotypes' observed an abrupt change in the timing of sleep at around the age of 20 and propose this change as the first biological marker of the end of adolescence.

1,218 citations


Journal ArticleDOI
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.

1,205 citations


Journal ArticleDOI
TL;DR: The results suggest that DGCR8 and Drosha interact in human cells and reside in a functional pri-miRNA processing complex.

868 citations


Journal ArticleDOI
TL;DR: It is demonstrated herein that constitutive activation of the Rheb/mTOR/S6K cassette, whether by genetic deletion of TSC1 or TSC2 or by ectopic expression of RheB, is sufficient to induce insulin resistance.

780 citations


Journal ArticleDOI
TL;DR: The SEP4 gene is characterized, which shares extensive sequence similarity to and an overlapping expression pattern with the other SEP genes, and it is found that it contributes to the development of petals, stamens, and carpels in addition to sepals and that it plays an important role in meristem identity.

706 citations


Journal ArticleDOI
TL;DR: Like SCN neurons, single fibroblasts can function as independent circadian oscillators; however, lack of oscillator coupling in dissociated cell cultures leads to a loss of synchrony among individual cells and damping of the ensemble rhythm at the population level.

681 citations


Journal ArticleDOI
TL;DR: It is demonstrated that miR164-directed regulation of CUC1 is necessary for normal embryonic, vegetative, and floral development and exposed a posttranscriptional layer of NAC-domain gene regulation during plant development.

658 citations


Journal ArticleDOI
TL;DR: The results show that feature-based attention exerts a multiplicative modulation upon neuronal responses and that the strength of this modulation depends on the similarity between the attended feature and the cell's preferred feature, in line with the feature-similarity gain model.

Journal ArticleDOI
TL;DR: It is demonstrated that a number of other APOBEC family members from both humans and rodents can mediate anti-HIV effects, through cytidine deamination, and exhibit significantly distinct antiviral characteristics that may provide new insights into host-pathogen interactions.

Journal ArticleDOI
TL;DR: This work has shown that in metazoans, cell cycles can be actively coupled to growth, but in certain cell types extracellular signals may independently induce growth and division.

Journal ArticleDOI
TL;DR: The combined shotgun proteomics and RNA profiling approach is of high potential value to predict metabolic pathway prevalence and to define regulatory levels of gene expression on a pathway scale.

Journal ArticleDOI
TL;DR: Natural variation in spermatozoal traits among wild Atlantic salmon, a species naturally adapted to sperm competition, is used to examine how the relative influences of sperm number, velocity, longevity, and total length determine sperm competition success.

Journal ArticleDOI
TL;DR: In several model systems, factors crucial for setting this balance have now been identified, setting the stage for a molecular dissection of the underlying regulatory mechanisms.

Journal ArticleDOI
TL;DR: It is shown that bacterial peptidoglycans (PGN), but surprisingly not LPS, induce NALP3-mediated activation of caspase-1 and maturation of proIL-1beta, which may be the basis of the potent adjuvant activity of MDP.

Journal ArticleDOI
TL;DR: It is shown that the MAX3 gene of Arabidopsis is required for the production of a graft-transmissible, highly active branch inhibitor that is distinct from any of the previously characterized branch-inhibiting hormones.

Journal ArticleDOI
TL;DR: This work reports the first molecular-level characterization of regional chromatin changes that accompany a DSB formed by the HO endonuclease in Saccharomyces cerevisiae, and indicates that localization of repair proteins to breaks is not likely to be the main function of this histone modification.

Journal ArticleDOI
TL;DR: It is shown that reduced miRNA accumulation in hyl1 correlates with an increased accumulation of uncleaved target mRNAs, including meristem- and auxin-related genes, providing clues for the developmental abnormalities ofhyl1 and for the previous identification of hyL1 as a mutant with altered responses to phytohormones.

Journal ArticleDOI
TL;DR: It is proposed that Aurora B biorients chromosomes by directing MCAK to depolymerize incorrectly oriented kinetochore microtubules through phosphorylation of serine 196 in the neck region of M CAK.

Journal ArticleDOI
TL;DR: The steps and factors that are involved in the unequal inheritance of cell fate determinants in Drosophila and C. elegans are outlined and their potential conservation in vertebrates is discussed.

Journal ArticleDOI
TL;DR: A domain-based hierarchical clustering technique is developed that distinguishes structurally and functionally related subsets of 14-3-3 target proteins, including numerous proteins involved in the dynamic control of cell architecture that regulate cytoskeletal architecture.

Journal ArticleDOI
TL;DR: Cell-cell signalling mediated by the receptor Notch is used widely across the metazoans to determine cell fate and regulate pattern formation and several fundamental mechanisms that contribute to regulate Notch signaling activity in space and time are identified.

Journal ArticleDOI
TL;DR: It is shown that APOBEC3F is also a potent retroviral restrictor but that its activity, unlike that of APOBec3G, is partially resistant to HIV-1 Vif and results in a clear 5'-GA --> -AA Retroviral hypermutation preference.

Journal ArticleDOI
TL;DR: Visual attention is attracted by salient stimuli that 'pop out' from their surroundings and attention can also be voluntarily directed to objects of current importance to the observer.

Journal ArticleDOI
TL;DR: The data support an evolutionarily conserved function for SNX1 from yeast to mammals and provide functional insight into the molecular mechanisms underlying lipid-mediated protein targeting and tubular-based protein sorting.

Journal ArticleDOI
TL;DR: Results show a behavioral dissociation, based upon an individual's awareness for having learned a sequence of finger movements, which is sleep dependent for explicit skills but time dependent for implicit skills.

Journal ArticleDOI
TL;DR: This work has shown that Geminin plays a crucial role in inhibiting licensing in metazoans and, like cyclins, is inactivated by the APC/C, which ensures that no origin can fire more than once in a cell cycle.

Journal ArticleDOI
TL;DR: It is shown that the kinase ATR localizes to XY chromatin at the onset of MSCI and that this localization is disrupted in mice with a mutant form of the tumor suppressor protein BRCA1, and compelling evidence is provided that it is ATR that phosphorylates H2AX and triggers MSCi.