Showing papers in "Current Biology in 2005"

TL;DR: For example, Frith as discussed by the authors showed that children with autism have a specific problem with theory-of-mind tasks, such as looking for the hidden chocolate in the cupboard.

TL;DR: This study suggests that STIM proteins function as Ca(2+) store sensors in the signaling pathway connecting Ca(1+)-store-depletion-mediated Ca( 2+) influx, and suggests that this mutant failed to respond to store depletion.

TL;DR: These results provide new insight into auxin transport dynamics during primordial positioning and suggest a role for Auxin transport in influencing primordial cell type.

TL;DR: Channelrhodopsin-2 (ChR2) is employed, a directly light-gated cation channel from the green alga Chlamydomonas reinhardtii, in excitable cells of the nematode Caenorhabditis elegans, to trigger specific behaviors, simply by illumination, in neurons and muscles.

TL;DR: This work shows that Rheb binds to the TOR complex specifically, independently of its ability to bind TSC2, through separate interactions with the mTOR catalytic domain and with LST8, whose binding enables activation of the TOR kinase.

TL;DR: These Or expression and ORN connectivity maps provide further insight into the molecular, anatomical, and functional organization of the Drosophila olfactory system and provide an essential resource for investigating how internal odor representations are generated and how they are further processed and transmitted to higher brain centers.

TL;DR: It is concluded that 3'-end methylation is a common step in miRNA and siRNA metabolism and likely protects the 3' ends of the small RNAs from the uridylation activity.

TL;DR: The results suggest that miRNAs have functional roles for plants to cope with fluctuations in mineral-nutrient availability in the soil and downregulates UBC mRNA accumulation by targeting the 5' UTR, and this regulation is important for plant responses to Pi starvation.

TL;DR: Individual psychogenomic pathways for bitter taste are mapped by testing people with a variety of psychophysical tasks and linking their individual perceptions of the compounds PTC and propylthiouracil to the in vitro responses of their TAS2R38 receptor variants.

TL;DR: Direct evidence is provided that BRAF activation is sufficient for f-nevus formation, that BRAf activation is among the primary events in melanoma development, and that the p53 and BRAF pathways interact genetically to produce melanoma.

TL;DR: It is proposed that KNOX proteins may act as general orchestrators of growth-regulator homeostasis at the shoot apex of Arabidopsis by simultaneously activating CK and repressing GA biosynthesis, thus promoting meristem activity.

TL;DR: It is shown that DCL4 is the primary processor of endogenous RDR6-dependent trans-acting siRNAs (tasiRNAs), and molecular and phenotypic analyses of all dcl double mutants revealed partially compensatory functions among DCL proteins.

TL;DR: A nearly complete map of OR projections from OSNs to the antennal lobe (AL) in the fly brain is presented and provides an experimental framework for relating ORs to glomeruli and ultimately behavior.

TL;DR: It is shown that downregulation of SAK in Drosophila cells, by mutation or RNAi, leads to loss of centrioles, the core structures of centrosomes, and that depletion of Sak in human cells also prevents centriole duplication and gives rise to mitotic abnormalities.

TL;DR: The authors' biochemical analysis revealed that Ago2 is present in a pre-miRNA processing complex that is able to transfer the miRNA into a target-mRNA cleaving complex, and these proteins are functionally required to mediate miRNA-guided mRNA cleavage.

TL;DR: The mystery of the natal origin of clownfish juveniles is solved by mass-marking via tetracycline immersion all larvae produced in a population, and parentage is established by DNA genotyping all potential adults and all new recruits arriving in the population.

TL;DR: It is shown that raw but not baked garlic activates TRPA1 and TRPV1, two temperature-activated ion channels that belong to the transient receptor potential (TRP) family that are present in the pain-sensing neurons that innervate the mouth.

TL;DR: These analyses provide the first strong support for a single endosymbiotic event that gave rise to primary photosynthetic eukaryotes, the Plantae, which are present in green plants, red algae, and glaucophytes.

TL;DR: It is proposed that ciliary PDGFRalphaalpha signaling is linked to tissue homeostasis and to mitogenic signaling pathways.

TL;DR: It is proposed that APOBEC3G can achieve an anti-HIV-1 effect through an undescribed mechanism that is distinct from cytidine deamination, and this findings reveal the nonequivalency of APOBec3G's N- and C-terminal domains and imply thatAPOB EC3G-mediated DNA editing may not always be necessary for antiviral activity.

TL;DR: It is concluded that activation of cytokinin biosynthesis mediates KNOXI function in meristem maintenance and emerges as central regulators of hormone levels in plant meristems.

TL;DR: The characterization of AtMYB60, a R2R3-MYB gene of Arabidopsis, is reported as the first transcription factor involved in the regulation of stomatal movements and opens new possibilities to engineeringStomatal activity to help plants survive desiccation.

TL;DR: It is demonstrated here that a single Acp, the sex peptide (SP or Acp70A), which decreases female receptivity and stimulates egg production in the first matings of virgin females , is a major contributor to Acp-mediated mating costs in females.

TL;DR: The intracellular feedback loops that form the core of the Drosophila circadian oscillator are described and it is considered how they are entrained by environmental light cycles, where they operate within the fly andHow they are thought to control overt rhythms in physiology and behavior.

TL;DR: The presence of five meiosis-specific genes indicates that Giardia is capable of meiotic and, thus, sexual reproduction, and the evolution of meiosis occurred early in eukaryotic evolution.

TL;DR: The "Mad2 template" model predicts a mechanism for cytosolic propagation of the spindle checkpoint signal away from kinetochores and proposes that closed Mad2 bound to Mad1 represents a template for the conversion of open Mad2 into closed Mad 2 bound to Cdc20.

TL;DR: Evidence that in Drosophila, a component of the ring gland, the prothoracic gland (PG), assesses growth to determine when critical weight has been achieved is presented, suggesting a role for photoperiod-gated PTTH secretion.

TL;DR: It is reported that the behavioral FIE is closely associated with the fMRI response in the FFA, but not in other face-selective or object- selective regions.

TL;DR: The results indicate that hyphal cells are specialized to present adherence molecules that support biofilm integrity, and BCR1 is a downstream component of the hyphal regulatory network that couples expression of cell-surface genes to hyphal differentiation.

TL;DR: A function for a newly identified ncRNA, TUG1, has been established and is necessary for the proper formation of photoreceptors in the developing rodent retina.