Showing papers in "Current Biology in 2006"

TL;DR: A recent review as mentioned in this paper highlights the emerging evidence that provides molecular definition to mitochondria as a central platform in the execution of diverse cellular events, including cell-cycle control, development, antiviral responses and cell death.

TL;DR: The first neuroimaging study to distinguish whether this "mirror system" uses specialized motor representations or general processes of visual inference and knowledge to understand observed actions is reported, showing that mirror circuits have a purely motor response over and above visual representations of action.

TL;DR: It is shown that the kinesin-1 cargo protein JNK-interacting protein 1 (JIP1) is localized to only a subset of neurites in cultured neuronal cells, and microtubule PTMs are important markers of distinct microtubules populations and that they act to control motor-protein trafficking.

TL;DR: It is demonstrated that food supplementation with resveratrol prolongs lifespan and retards the expression of age-dependent traits in a short-lived vertebrate.

TL;DR: This study directly visualized transcription of an endogenous developmental gene and found discrete "pulses" of gene activity that turn on and off at irregular intervals, which represents the first direct visualization of transcriptional pulsing in eukaryotes.

TL;DR: It is proposed that cells contain several mTORC2 flavors that may phosphorylate Akt/PKB in response to different signals.

TL;DR: A significant role for NETs in neutrophil-mediated innate immunity is demonstrated, and a novel therapeutic target against invasive GAS infection is identified.

TL;DR: Results suggest a key role of mirror neuron areas in the re-enactment of sensory-motor representations during conceptual processing of actions invoked by linguistic stimuli.

TL;DR: It is demonstrated that antagonistic modulatory subsystems are sufficient to substitute for aversive and appetitive reinforcement during classical conditioning and that distinct neuronal populations can be activated simply by illuminating the animals with blue light.

TL;DR: In this paper, the authors search for brain areas that respond both during motor execution and when individuals listened to the sound of an action made by the same effector, finding that a left hemispheric temporo-parieto-premotor circuit is activated in both cases.

TL;DR: It is shown here that CRACM1 forms multimeric assemblies that bind STIM1 and that acidic residues in the transmembrane and extracellular domains of CRacM1 contribute to the ionic selectivity of the CRAC-channel pore.

TL;DR: It is shown that the juvenile-to-adult phase transition is normally suppressed by TAS3 ta-siRNAs, in an ARGONAUTE7-dependent manner, through negative regulation of ARF3 mRNA.

TL;DR: Pneumococci are trapped but, unlike many other pathogens, not killed by NETs, and it is demonstrated that escaping NETs promotes spreading of pneumococci from the upper airways to the lungs and from the lungs into the bloodstream during pneumonia.

TL;DR: It is revealed that up to 20% of soluble proteins assayed in mouse liver are subject to circadian control, and almost half of the cycling proteins lack a corresponding cycling transcript, revealing for the first time the extent of posttranscriptional mechanisms as circadian control points.

TL;DR: It is found that in the absence of microtubules, escape from mitosis occurs in the presence of an active SAC and requires cyclin B destruction, and vertebrate cells do not adapt to the SAC.

TL;DR: The results provide causal evidence that circuits originating in the human FEF can modulate activity in retinotopic visual cortex, in a manner that differentiates the central and peripheral visual field, with functional consequences for perception.

TL;DR: In this paper, the authors demonstrate the migration of an interphase chromosome site from the nuclear periphery to the interior 1-2 hours after targeting a transcriptional activator to this site.

TL;DR: It is shown that the resistance of max mutant buds to apically supplied auxin is largely independent of the known, AXR1-mediated, auxin signal transduction pathway, and modulation of auxin transport in the stem is sufficient to regulate bud outgrowth, independent of AXR 1-mediated auxin signaling.

TL;DR: The massive nature of histone association with droplets and its developmental time-course suggest that droplets sequester maternally provided proteins until they are needed, which may provide a general cellular strategy for handling excess proteins.

TL;DR: It is suggested that in cases where the resources for enforcement are lacking, management regimes that are designed to meet community goals can achieve greater compliance and subsequent conservation success than regimes designed primarily for biodiversity conservation.

TL;DR: A new experimental pipeline to assay 3' UTR-mediated posttranscriptional gene regulation via an endogenous reporter expression system amenable to high-throughput cloning is developed, demonstrating the utility of this system using one of the most intensely studied miRNAs, let-7.

TL;DR: Results indicate that the dsRNA binding protein DRB4 is required for proper ta-siRNA production, presumably by interacting with DCL4, an interaction analogous to that of HYL1 with D CL1 during miRNA production , and that TAS3 ta-SIRNAs are required for Proper leaf development through the action of AGO7/ZIPPY.

TL;DR: Accumulating support is shown for the hypothesis that high quality females show the strongest mate preference, and some of the wider implications of condition-dependent mating decisions and their effect on the strength of sexual selection are examined.

TL;DR: It is demonstrated that ROCK regulates the phosphorylation of MLC just behind the invading margin of the cell, and that inhibition of ROCK but not matrix-metalloproteases reduces cancer cell motility in vivo.

TL;DR: Using real-time imaging of cellular circadian gene expression across entire SCN slice cultures, it is shown for the first time that the Vipr2 gene encoding the VPAC2 receptor for VIP is necessary both to maintain molecular timekeeping within individual SCN neurons and to synchronize molecularTimekeeping between SCN neuron embedded within intact, organotypical circuits.

TL;DR: It is shown that songs that are important to mate attraction and territory defense have significantly diverged in great tits (Parus major), a very successful urban species, and provides the most consistent evidence supporting the acoustic-adaptation hypothesis since it was postulated in the early seventies.

TL;DR: Surprisingly, phase-shift reversal was primarily driven by a single batfish species (Platax pinnatus), a fish previously regarded as an invertebrate feeder, suggesting that biodiversity may not offer the protection the authors hoped for in complex ecosystems.

TL;DR: The results support a preanaphase correction mechanism for merotelic attachments in which correct plus-end attachments are pulled away from high concentrations of Aurora B at the inner centromere, and incorrect merotELic attachments are destabilized by being pulled toward the inner Centromere.

TL;DR: A pathway from agonist stimulation to integrin activation is ordered and the Rap1-induced formation of an "integrin activation complex," containing RIAM and talin, that binds to and activates the integrin is established.

TL;DR: In vitro reconstitution experiments demonstrate that Wapl forms a stoichiometric, ternary complex with two regulatory subunits of cohesin, implicating its noncatalytic function in inactivating cohesIn's ability to interact with chromatin.