Journal•ISSN: 1473-6322
Current Opinion in Allergy and Clinical Immunology
Lippincott Williams & Wilkins
About: Current Opinion in Allergy and Clinical Immunology is an academic journal published by Lippincott Williams & Wilkins. The journal publishes majorly in the area(s): Asthma & Medicine. It has an ISSN identifier of 1473-6322. Over the lifetime, 1861 publications have been published receiving 63084 citations. The journal is also known as: Curr Opin Allergy Clin Immuno & Curr Opin Allergy Clin Immunol.
Topics: Asthma, Medicine, Food allergy, Allergy, Population
Papers published on a yearly basis
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TL;DR: This review summarizes current knowledge on the incidence, prevalence, mortality and risk factors for hypersensitivity drug reactions in different populations.
Abstract: Purpose of review Hypersensitivity drug reactions are but one of the many different types of adverse drug reactions. They may be potentially life-threatening, prolong hospitalization, affect drug prescribing patterns of physicians and result in socioeconomic costs. This review summarizes current knowledge on the incidence, prevalence, mortality and risk factors for these reactions in different populations. Recent findings Hypersensitivity reactions represent about one third of all adverse drug reactions. Adverse drug reactions affect 10-20% of hospitalized patients and more than 7% of the general population. Severe reactions including anaphylaxis, drug hypersensitivity syndromes, Stevens Johnson syndrome and toxic epidermal necrolysis are also associated with significant morbidity and mortality. Although several risk factors have been identified, their clinical importance has not been fully understood. Future progress in immunogenetics and pharmacogenetics may help identify populations at risk for specific types of reactions. Summary Well designed epidemiological studies on hypersensitivity drug reactions are lacking as most studies have been on adverse drug reactions. Such studies will be helpful in identifying patients at risk of developing such reactions, in particular severe reactions, and implementing early preventive measures.
383 citations
TL;DR: Examination of other mechanisms (e.g. oxidative stress pathways, glucocorticoid resistance, nerve–mast cell interactions, intestinal dysbiosis) and a broader range of cytokines and neuropeptides produced by cells both within and outside the immune system may better delineate the true complexity of the underlying mechanisms linking stress to allergic sensitization and asthma.
Abstract: Summary Psychological stress may be conceptualized as a social pollutant that, when ‘breathed’ into the body, may disrupt biological systems related to inflammation through mechanisms potentially overlapping with those altered by physical pollutants and toxicants.
345 citations
TL;DR: An enhanced Th2 immune response and the elaboration of cytokines such as IL-4, IL-13, and IL-5 contribute to the induction of allergy and asthma.
Abstract: Purpose of reviewThis review examines recent articles on the relationship of cytokines to allergy and asthma with particular emphasis on immune mechanisms involved in disease development in early life.Recent findingsIt was previously proposed that reduced microbial exposure in early life is responsi
331 citations
TL;DR: The appropriate management after recovery from a severe reaction may be protective against a fatal recurrence, and an accurate identification of the cause and effective avoidance is a crucial part of this management.
Abstract: PURPOSE OF REVIEW Anaphylaxis is frightening and patients commonly fear their next reaction will be fatal. This review looks at the characteristics of fatal reactions to find if a fatal recurrence is predictable. RECENT FINDINGS Most publications on fatal anaphylaxis are case reports that do not help predict risks. Most epidemiological studies focus on non-fatal reactions. The UK fatal anaphylaxis register demonstrates that over two-thirds of those dying from sting reactions and over four-fifths dying from drug anaphylaxis had no previous indication of their allergy, whereas those dying from food allergy had usually had previous reactions but these were typically not severe. Recent reports of anaphylaxis epidemiology based on diagnostic coding or attendance for treatment may be biased by differences in health service resource utilization according to the cause and course of the reaction. SUMMARY Most fatal anaphylactic reactions are unpredictable. The appropriate management after recovery from a severe reaction may be protective against a fatal recurrence. An accurate identification of the cause and effective avoidance is a crucial part of this management, together with effective treatment of asthma for those with food allergy, immunotherapy for sting allergy, the avoidance of drugs that potentiate anaphylaxis, and effective training in self-treatment.
318 citations
TL;DR: New concepts on the role of mucins in the protection of corneal and conjunctival epithelia are described and alterations in mucin and mucin O-glycan biosynthesis in ocular surface disorders, including allergy, nonautoimmune dry eye, autoimmune dry eye and infection are presented.
Abstract: Purpose of reviewThe purpose of the present review is to describe new concepts on the role of mucins in the protection of corneal and conjunctival epithelia and to identify alterations of mucins in ocular surface diseases.Recent findingsNew evidence indicates that gel-forming and cell surface-associ
291 citations