Journal•ISSN: 0959-437X
Current Opinion in Genetics & Development
Elsevier BV
About: Current Opinion in Genetics & Development is an academic journal published by Elsevier BV. The journal publishes majorly in the area(s): Chromatin & Genome. It has an ISSN identifier of 0959-437X. Over the lifetime, 3084 publications have been published receiving 265516 citations. The journal is also known as: Current opinion in genetics and development.
Topics: Chromatin, Genome, Biology, Regulation of gene expression, Medicine
Papers published on a yearly basis
Papers
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TL;DR: Research in the past two years reveals these modifications to consist of phosphorylation, methylation and ubiquitination, in addition to the better-characterized acetylation, which argues persuasively for the existence of a histone code.
1,215 citations
TL;DR: Many metabolic abnormalities in cancer cells increase HIF-1 activity, and a feed-forward mechanism can be activated that drives Hif-1 activation and may promote tumor progression.
1,184 citations
TL;DR: A decade after the beginning of the genomic era, the question of how genomics can describe a bacterial species has not been fully addressed and the pan-genome, which is composed of a "core genome" containing genes present in all strains, and a "dispensable genome", might be orders of magnitude larger than any single genome.
1,099 citations
TL;DR: Hypoxia-inducible factor 1 is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals and the effects of HIF-1 deficiency on cellular physiology and embryonic development are provided.
1,078 citations
TL;DR: Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.
987 citations