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JournalISSN: 1746-630X

Current Opinion in Hiv and Aids 

Lippincott Williams & Wilkins
About: Current Opinion in Hiv and Aids is an academic journal published by Lippincott Williams & Wilkins. The journal publishes majorly in the area(s): Population & Medicine. It has an ISSN identifier of 1746-630X. Over the lifetime, 1270 publications have been published receiving 38588 citations. The journal is also known as: Current opinion in HIV & AIDS & HIV and AIDS.


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Journal ArticleDOI
TL;DR: Working definitions and a conceptual framework are provided to understand the roles of biomarkers in clinical research and considers select cases in which misunderstandings about the terms led to flawed research conclusions.
Abstract: Purpose This article provides working definitions and a conceptual framework to understand the roles of biomarkers in clinical research.

1,627 citations

Journal ArticleDOI
TL;DR: Although there is a plausible link between STI and HIV risk, intervention studies continue to be disappointing and mechanisms of action and the design and implementation of interventions need to be better understood.
Abstract: Purpose of reviewWe review recent evidence about the link between sexually transmitted infections (STI) and HIV transmission and consider implications for control programmes.Recent findingsNew studies and meta-analyses confirm the association of HIV acquisition and transmission with recent STIs, alt

316 citations

Journal ArticleDOI
TL;DR: The global prevalence of HIV has stabilized in this decade, but with important regional differences in trends and modes of transmission, prevention and treatment programs have an expanding impact in preventing HIV infection and AIDS deaths.
Abstract: PURPOSE OF REVIEW: To provide an update on the epidemiology of HIV worldwide and by region along with an overview of recent HIV epidemiological research. RECENT FINDINGS: The global prevalence of HIV-1 has stabilized at 0.8% with 33 million people living with HIV/AIDS 2.7 million new infections and 2.0 million AIDS deaths in 2007. Heterosexual spread in the general population is the main mode of transmission in sub-Saharan Africa which remains the most heavily affected region with 67% of the global burden. Male-male sex injection drug use and sex work are the predominant risk factors in most other regions. Infection rates are declining in some regions including some of the most heavily affected countries in Africa but climbing elsewhere such as in eastern Europe and central Asia. Recent HIV epidemiologic research findings include new insights into the role of HIV viral load co-infection with sexually transmitted infections male circumcision antiretroviral treatment serosorting and superinfection in HIV transmission and prevention. SUMMARY: The global prevalence of HIV has stabilized in this decade but with important regional differences in trends and modes of transmission. Prevention and treatment programs have an expanding impact in preventing HIV infection and AIDS deaths.

315 citations

Journal ArticleDOI
TL;DR: It is proposed that both the quantity and quality of HIV-susceptible target cells in the exposed genital or rectal mucosa may be key predictors of HIV susceptibility.
Abstract: Purpose of reviewThe HIV sexual transmission probability measured in the context of discordant couples appears too low to fuel the HIV pandemic, but these rates are substantially amplified by specific co-factors. The most consistent predictors of transmission are the HIV levels in the blood and geni

268 citations

Journal ArticleDOI
TL;DR: A randomized, clinical trial demonstrated that antiretroviral therapy reduces the sexual transmission of HIV in HIV-serodiscordant couples by more than 96% and proved central to the development of new global HIV-prevention efforts.
Abstract: Purpose of reviewThis review summarizes the development and implementation of a large clinical trial, HIV Prevention Trials Network (HPTN) 052, whose initial results were recently presented and published.Recent findingsA randomized, clinical trial demonstrated that antiretroviral therapy reduces the

261 citations

Performance
Metrics
No. of papers from the Journal in previous years
YearPapers
202339
2022109
202140
202051
201968
201865