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Showing papers in "Current Opinion in Microbiology in 2021"


Journal ArticleDOI
TL;DR: It is proposed that re-examining the role of cell death and inflammatory cytokines through the lens of PANoptosis will advance the understanding of host–pathogen evolution and may reveal new treatment strategies for controlling a wide range of infectious diseases.

67 citations


Journal ArticleDOI
Bo Wang1, Xiang-Jin Meng1
TL;DR: Recent advances in HEV host range, and cross-species and zoonotic transmission are discussed, and a large number of animal HEV variants do provide an opportunity to develop useful animal models for HEV.

58 citations


Journal ArticleDOI
TL;DR: The latest discoveries on the molecular mechanisms of antiviral TRIM proteins are summarized and the current and future trends in this fast-evolving field are discussed.

49 citations


Journal ArticleDOI
TL;DR: In this paper, the focus of mycovirology research has expanded from plant pathogenic fungi and mycovirus mediated hypovirulence to include insect and humanpathogenic fungi together with a range of myculi- mediated phenotypes, such as hypervirulence, control of endophytic traits, regulation of metabolite production and drug resistance.

40 citations


Journal ArticleDOI
TL;DR: The PAS fold is composed of an antiparallel β-sheet with several flanking α-helices, and contains a conserved cleft for cofactor or ligand binding.

32 citations


Journal ArticleDOI
TL;DR: In this paper, the N-terminal β-strand of BamA is captured by hydrogen bonding to allow their directional folding and subsequent release into the membrane, and a model for a substrate assembly at the lateral opening of the BamA was proposed.

31 citations


Journal ArticleDOI
TL;DR: In this paper, the authors discuss several aspects regarding IAPA and CAPA, including their possible pathogenesis, the use of immunotherapy, and future challenges, as well as future challenges.

28 citations


Journal ArticleDOI
TL;DR: Carboxysomes are CO2-fixing protein compartments present in all cyanobacteria and some proteobacteria as mentioned in this paper, and are attractive candidates for carbon assimilation bioengineering because they concentrate carbon, allowing the fixation reaction to occur near its maximum rate, and because they self-assemble in diverse organisms with a set of standard biological parts.

28 citations


Journal ArticleDOI
TL;DR: In this article, the authors proposed using antimicrobial resistant Escherichia coli as indicators for monitoring occurrence and levels of AMR in the environment, including wildlife, and proposed an urgent need to initiate environmental AMR monitoring programs nationally and globally, which will complement existing systems in different sectors.

28 citations


Journal ArticleDOI
TL;DR: In the past 15 years, three more cyclic dinucleotide (cdN) second messengers have been discovered: 3′−5′, 3′-5′ and 3′ −5′ cyclic di-GMP (c-di-AMP) as discussed by the authors.

27 citations


Journal ArticleDOI
TL;DR: In this article, the authors proposed a methodologies for tracking AMR, including metagenomics, but need to be standardized and made modular for access by LMICs, while also developing systems for sample archiving and data sharing.

Journal ArticleDOI
TL;DR: The gut epithelium prevents bacterial access to the host's tissues and coordinates a number of mucosal defenses, which may enable defense against the challenges imposed by diverse bacterial enteropathogens.

Journal ArticleDOI
TL;DR: It is hypothesize that class A PBP function is essential in walled bacteria unless they have (a) SEDS protein(s) capable of replacing their function.

Journal ArticleDOI
TL;DR: In this paper, the authors summarize advances and expose gaps in our current understanding of the diversity of chemosensory systems, revealing substantial diversity in system design, functional regulation, cellular localization and phyletic distribution.

Journal ArticleDOI
TL;DR: In this article, a review briefly describes mycobacterial cell wall synthesis, and focuses on aspects of remodelling and recycling, thus highlighting opportunities for future research and highlighting the need for new anti-tubercular agents and drug targets.

Journal ArticleDOI
TL;DR: This paper reviewed recent observations of how flagella shape motility behaviors and summarized the nascent structure-function map linking flagellation and behavior, concluding that the structure function map can be used to predict motility behavior.

Journal ArticleDOI
TL;DR: The rise of antibiotic failure poses a severe threat to global health and there is growing concern that this failure is not solely driven by stable antibiotic resistance but also by a subpopulation of transiently non-growing, antibiotic tolerant bacteria.

Journal ArticleDOI
TL;DR: In this article, the authors reviewed current information on the population structure of Pseudomonas aeruginosa and on the functional role that its resistance and virulence determinants have in non-clinical ecosystems.

Journal ArticleDOI
TL;DR: In this article, the evolutionary history of BMCs is investigated from the perspective of their shells, which are comprised of two structural modules, distinct domains that form pentagonal and hexagonal building blocks which occupy the vertices and facets, respectively.

Journal ArticleDOI
TL;DR: In this paper, the authors highlight the current approaches that are employed to treat bacterial biofilm infections and discuss new approaches in development that have promise to reach clinical practice, and highlight the different stages of biofilm formation, including complex signalling networks, chemical gradients, bacterial adhesion, and matrix components.

Journal ArticleDOI
TL;DR: This review describes the application of CRISPR tools for functional genomics screens in bacteria, with a focus on the use of interference (CRISPRi) approaches, and provides a forward-looking analysis of CRisPRi strategies for determining gene function in bacteria.

Journal ArticleDOI
TL;DR: Recent engineering approaches applied in vivo in animal models are summarized and promising technologies for designing the next generation of bacterial biosensors are highlighted.

Journal ArticleDOI
TL;DR: Natural transformation is a process where bacterial cells actively take up free DNA from the environment and recombine it into their genome or reconvert it into extra-chromosomal genetic elements as mentioned in this paper.

Journal ArticleDOI
TL;DR: In this paper, the authors consider how environmental pollution can favour the selection of bacterial pathogens in the environment and identify key pollutants that are associated with antibiotic resistance and discuss possibilities of how to prevent their release into the environment.

Journal ArticleDOI
TL;DR: In this paper, the authors summarize recent findings explaining IEC invasion by type-threesecretion-system-1 (TTSS-1) effector proteins and discuss their effects on invasion and gut inflammation.

Journal ArticleDOI
TL;DR: In this paper, the authors highlight recent advances in understanding the protein composition and stoichiometry of BMCs, with a particular focus on carboxysomes and propanediol utilization microcompartments.

Journal ArticleDOI
TL;DR: This work reviews existing modeling techniques to construct dynamic models of microbial communities at different scales and suggests ways to leverage multiple types of models and data to facilitate the understanding and engineering of microbial Communities.

Journal ArticleDOI
TL;DR: In this paper, the authors discuss the current understanding of antibiotic tolerance and persistence, outlining how tolerance and persistent can be distinguished experimentally, and evaluate the clinical evidence implicating antibiotic tolerance in recalcitrance and relapse of bacterial infections.

Journal ArticleDOI
TL;DR: In this article, insights are reviewed into the mechanisms underlying circumvention of the host cell death by Shigella, as an example of bacterial fine-tuning of host cellDeath pathways.

Journal ArticleDOI
TL;DR: In this article, the authors proposed a method to predict invasive potential, host-adaptation and zoonotic risk of Salmonella from sequence data to improve outbreak investigation, risk assessment and control strategies.