Journal•ISSN: 2452-3100
Current Opinion in Systems Biology
Elsevier BV
About: Current Opinion in Systems Biology is an academic journal published by Elsevier BV. The journal publishes majorly in the area(s): Systems biology & Synthetic biology. It has an ISSN identifier of 2452-3100. Over the lifetime, 396 publications have been published receiving 6586 citations.
Topics: Systems biology, Synthetic biology, Computer science, Biology, Gene
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TL;DR: This review focuses on single cell transcriptomics and highlights the inherent opportunities and challenges in the context of big data analytics.
178 citations
TL;DR: This review will discuss how recent studies applied machine learning approaches in functional profiling workflows with a focus on chemical genetics to enable discoveries and develop methodologies that lower the entry barriers to high-throughput profiling experiments.
120 citations
TL;DR: This review covers manifold learning-based methods for denoising the data, revealing gene interactions, extracting pseudotime progressions with model fitting, visualizing the cellular state space via dimensionality reduction, and clustering the data.
119 citations
TL;DR: Some of the history of theoretical and experimental aspects of the field of cell polarization are described, as well as some interesting questions and challenges for the future.
95 citations
TL;DR: Computational modeling resources and frameworks developed recently for reconstructing GEMs of microorganisms and microbial communities together with their applications are reviewed.
87 citations