Journal•ISSN: 2468-2020
Current Opinion in Toxicology
Elsevier BV
About: Current Opinion in Toxicology is an academic journal published by Elsevier BV. The journal publishes majorly in the area(s): Oxidative stress & Hormesis. It has an ISSN identifier of 2468-2020. Over the lifetime, 358 publications have been published receiving 6257 citations.
Papers
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TL;DR: A greater understanding of the complex interplay between the NF-κB signaling and oxidative stress may lead to the development of therapeutic strategies for the treatment of a myriad of human diseases for which oxidative stress has an etiologic role.
417 citations
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TL;DR: Small molecule activators of Nrf2 support mitochondrial integrity by promoting mitophagy and conferring resistance to oxidative stress-mediated permeability transition, with implications for stem cell self-renewal, cardiomyocyte regeneration, and neural stem/progenitor cell survival.
253 citations
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TL;DR: This review highlights the differences between Cr(VI) and Cr(III) from a chemical and toxicological perspective, describes short-comings in nutritional research of Cr( III), and explains the multiple mechanisms by which Cr( VI) is involved in the process of carcinogenesis.
187 citations
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TL;DR: Sies et al. as discussed by the authors defined a global concept of Oxidative Stress as an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control and/or molecular damage.
169 citations
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TL;DR: Specific examples whereby ROS generated by CYPs contribute to or protect against various phenomena, such as hyperoxic lung injury, oxidative hepatic toxicity, formation of DNA adducts from lipid peroxidation products are discussed.
148 citations