Showing papers in "Cytokine & Growth Factor Reviews in 2019"

TL;DR: This review will focus on the accumulating evidence that points to the therapeutic potential of the conditioned medium, both from pre-clinical and clinical studies, and the importance of profiling the conditionedmedium for assessing its potential for cell-free therapy therapy.

TL;DR: Advances in the basic biology of the CD14 including its structure, binding ligands, signaling pathways, and its roles in the pathogenesis of inflammation, atherosclerosis, tumor and metabolic diseases are summarized.

TL;DR: Findings underline the crucial regulatory role of IL-23 in chronic intestinal inflammation and colitis-associated cancer and indicate that therapeutic strategies aiming at IL- 23 blockade may be of key relevance for future therapy of IBD patients.

TL;DR: The diverse mechanisms of oncogenic activation of STAT3, and the small molecule inhibitors ofSTAT3 in cancer treatment are discussed.

TL;DR: Photobiomodulation-PBM is efficient in the visible red and near-infrared electromagnetic spectrum, and fluencies ranging from 2 to 6 J/cm2, however, cellular and molecular mechanisms induced by PBM are not fully understood.

TL;DR: Emerging findings on the pathological roles of synovial macrophage, adipose tissue macrophages, and osteoclasts in OA and their potential clinical implications from cell biology to preclinical and preliminary clinical trials are summarized.

TL;DR: The role of IL-5 and IL-18 in eosinophils development, transformation, maturation, signal transduction, and the role of several other associated cytokines in promoting eosInophils mediated allergic diseases are discussed.

TL;DR: This review resumes knowledge on the crosstalk between collagen type I and selected NCPs of bone matrix and focuses on their possible involvement and role in osteoporosis.

TL;DR: In this article, the authors summarize available knowledge of PGRN targeting in various kinds of diseases, including common neurological diseases, inflammatory autoimmune diseases, cancer, tissue repair, and rare lysosomal storage diseases, with a focus on the functional domain oriented drug development strategies.

TL;DR: In this article, the authors discuss the favorable adipokines like adiponectin, omentin, C1q tumor necrosis factor-related proteins, but also unfavorable ones like resisitin and visfatin, in the aim of finding potential biomarkers recommended for the clinical use in the diagnosis, prognosis and follow up of patients with Type 2 diabetes at high risk of developing cardiovascular diseases as well as leading to new therapeutic approaches.

TL;DR: The biological features and recent advances in the role of IL-13 in the development and pathogenesis of autoimmune diseases are summarized to provide new perspectives and suggestions for the selection of therapeutic targets for autoimmune diseases.

TL;DR: The mechanisms by which MSCs modulate the immune response and the main advances in the licensing of these cells are discussed, with a special focus on the use of interferon gamma (IFN-γ).

TL;DR: The main focus is on the interplay between immune cell network including the innate and adaptive immune system, regulatory cells, immune checkpoints and recently identified tissue-resident memory cells (TRMs) in disease pathogenesis and relapse.

TL;DR: This work explores how skin layers, including the epidermis, dermis, adipose tissue, and skin appendages, as well as cutaneous microbiota, contribute to the function of skin antimicrobial defense, and explores the versatility of the mechanisms underlying skin defense.

TL;DR: Melatonin can serve as a potential new therapeutic target, creating opportunities for the treatment of autoimmune diseases, with particular focus given to novel signaling pathways involved in Th17 and Tregs as well as cell proliferation and apoptosis.

TL;DR: This study, which for the first time summarizes reported knowledge on Dlk1 in tissue development and regeneration as well as on the DlK1 mechanism, may provide novel insight to the general role of this remarkable imprinted gene in controlling cell growth.

TL;DR: The IGFBPs have been heavily implicated inAngiogenesis, both pathological and physiological, and they have significant promise as targeted cell therapy agents for both pathological angiogenesis inhibition and therapeutic angiogenic following ischemic injury.

TL;DR: The IL-1 family comprises two anti-inflammatory cytokines, two receptor antagonists, and seven ligand agonists, which appear to be involved in the pathogenesis of diverse diseases as well as inflammatory and autoimmune disorders.

TL;DR: The functional role of endogenously expressed and exogenously applied ALR is highlighted, as well as an analysis of the clinical importance of ALR, with emphasis on liver disease and in vivo models, aswell as the consequences of mutations in the GFER gene.

TL;DR: The present review addresses the novel role of HMGB1 in secretion and cardiomyocyte senescence and in the dual faced roles of HM GB1 in cardiac inflammatory injury, inflammatory resolution and cardiac regeneration and remodelling following cardiac injury.

TL;DR: The interactions between CEACAMs and bacteria adhesion in relation to IBD pathophysiology will be addressed and potential new therapeutic and diagnostic opportunities will be identified.

TL;DR: The transition model of receptor tyrosine kinase (RTK) activation is discussed, which is derived from biophysical investigations of RTK interactions and signaling and provides a framework to understand RTK activity and to make predictions in quantitative terms.

TL;DR: This review will focus on the role of DC-derived OPN in shaping immune response and on the complex role of this cytokines in the regulation in immune response.

TL;DR: It is indicated that elabela is crucial for embryo cardiovascular system formation and early placental development, while apelin acts in mid/late gestation to modulate fetal angiogenesis and energy homeostasis and apelin levels are increased during PE, but the use of apelin as an early PE marker remains to be fully investigated.

TL;DR: The aim of this study was to give a profound review of recent data on the role of IL-18 and its potential as a therapeutic target in pancreatic diseases.

TL;DR: The role of the stroma and PSCs in PC development, invasion and metastasis is explored, their interaction with PC cells is examined, and potential treatment approaches aimed at targeting P SCs in order to reprogram the pancreatic tumor environment are discussed.

TL;DR: The clinical potential of the expression, regulation and function of IL-33/ST2 pathway in predicting disease activity and severity and offer possible future therapeutic alternatives are discussed.

TL;DR: This review will explore the advances in the field of FRα-based immune therapies and discuss both their successes and shortcomings in the clinical setting.

TL;DR: Findings that indicate a regulatory role for calcium signalling in innate and autoimmunity through the cGAS-STING pathway are summarized.

TL;DR: Growing body of evidence strongly suggest that CA2+ signaling, tumor necrosis factor alpha (TNFα) and transforming growth factor beta (TGFβ) also play very important roles in the regulation of circadian rhythms by regulating the transcription of the clock genes.