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Showing papers in "Diabetes Research and Clinical Practice in 1995"


Journal ArticleDOI
TL;DR: In conclusion, intensive glycemic control by multiple insulin injection therapy can delay the onset and the progression of diabetic retinopathy, nephropathy and neuropathy in Japanese patients with NIDDM.

2,927 citations



Journal ArticleDOI
TL;DR: It is concluded that diabetes and IGT are associated with low serum concentrations of 25-hydroxyvitamin D3 and that low concentrations of this hormone in New Zealand Polynesians may partly explain their increased prevalence of diabetes/IGT compared with Europeans.

291 citations


Journal ArticleDOI
TL;DR: It is confirmed that diabetics have significantly lower vagal activity than non-diabetics, and serum insulin and, to a lesser degree, serum glucose were inversely associated with vagal function, suggesting a role in the pathogenesis of diabetic neuropathy.

157 citations


Journal ArticleDOI
TL;DR: The studies on the molecular mechanism of extrapancreatic activity with rat adipocytes and diaphragm suggest that these direct insulin-mimetic effects rely on the induction of GLUT4 translocation from internal stores to the plasma membrane and on the activation of the key metabolic enzymes, glycogen synthase and glycerol-3-phosphate acyltransferase.

120 citations


Journal ArticleDOI
TL;DR: It is concluded that the pre-filled insulin pen is safe, efficacious and is highly accepted in over 60 years old diabetic patients.

112 citations


Journal ArticleDOI
TL;DR: It is suggested that decreased expression of CR3 on monocytes, decreased lymphocyte proliferation and decreased IL-2R expression despite a higher production of TNF-alpha may explain the impaired cell-mediated immunity seen in NIDDM patients.

107 citations


Journal ArticleDOI
TL;DR: It is demonstrated that caloric restriction is effective in preventing NIDDM in diabetes-prone rats, probably due to increased insulin sensitivity.

91 citations


Journal ArticleDOI
TL;DR: The present data indicated that EPA-E administration improved increased albumin excretion in NIDDM patients with nephropathy and its effects on albuminuria sustained for at least 12 months after the start of treatment.

90 citations


Journal ArticleDOI
TL;DR: The UK Prospective Diabetes Study has randomly allocated 4209 newly diagnosed Type II diabetic patients to different therapies and is determining whether improved glucose control will delay the onset of clinical complications; and whether any specific therapy has advantages or disadvantages.

89 citations


Journal ArticleDOI
TL;DR: Clinical trials established efficacy and safety of glimepiride in comparison to placebo and glibenclamide and showed its therapeutic value, suggesting that there may be less risk of hypoglycaemia with glimePiride.

Journal ArticleDOI
TL;DR: This study was undertaken to determine if continuous subcutaneous insulin infusion (CSII) could improve control, diminish episodes of diabetic ketoacidosis (DKA), decrease number of hospitalizations and save health care expenditure in children and adolescents with long-standing poorly controlled diabetes mellitus.

Journal ArticleDOI
TL;DR: Those individuals within the chromium group with initial fasting IRI levels greater than 35 pmol/l had a significant decrease in IRI level after supplementation (P < 0.03) despite no significant changes in serum lipids, and may benefit from chromium supplementation by improving insulin sensitivity and cardiovascular risk over time.

Journal ArticleDOI
TL;DR: The results seem to confirm the previous suggestions concerning the relation between metabolic disturbances and oxidative stress in diabetic patients.

Journal ArticleDOI
TL;DR: Sudanese diabetic patients are more prone to both microvascular and macrovascular complications than previously reported and all efforts should be made to reduce the incidence of these complications.

Journal ArticleDOI
TL;DR: Data show that AGE levels are increased as early as 3 months from development of hyperglycemia; other factors, in addition to an enhanced rate of fluorescent AGE formation, might play important roles in the pathogenesis of diabetic cataract; and increased peripheral nerve AGE Levels are associated with SEP alterations.

Journal ArticleDOI
TL;DR: Multiple logistic regression analyses showed that serum cholesterol, serum creatinine, systolic BP, duration of diabetes and ishaemic heart disease are strong predictive factors for PVD in South Indians.

Journal ArticleDOI
TL;DR: After 12 months the patients in the orthotic group showed a significant reduction in callus grade, whereas the conventionally treated group showed no significant change.

Journal ArticleDOI
TL;DR: Not only did G AD65Ab presence predict future insulin dependence, but higher GAD65Ab levels may mark more rapid decline in beta-cell function in apparent non-insulin-dependent diabetes.

Journal ArticleDOI
TL;DR: These data suggest that uncooked cornstarch, as part of the evening snack, can diminish the nighttime and morning hypoglycemia associated with type 1 diabetes, without causing hyperglycemia.

Journal ArticleDOI
TL;DR: Anti-GAD are frequently detected by the RIA kit in patients with IDDM of short duration and this assay may be useful for population screening for IDDM and for better understanding of its pathogenesis.

Journal ArticleDOI
TL;DR: Pathological changes in the exocrine and endocrine pancreas in N IDDM results from and contributes to the pathophysiology of insulin secretion in NIDDM.

Journal ArticleDOI
TL;DR: In this paper, the effects of pravastatin on plasma lipid levels, in vitro oxidizability of the non-HDL fraction, metabolic control, urinary albumin excretion, and four serum enzymes (SGPT, SGOT, GT and CPK) were studied in 20 insulin-dependent diabetic patients (IDDM) with incipient nephropathy.

Journal ArticleDOI
S. Reddy1, N.J. Bibby1, D Wu1, C. Swinney1, G. Barrow1, Robert B. Elliott1 
TL;DR: It is concluded that the complete prevention of diabetes in the NOD mouse fed a casein-free diet together with nicotinamide is accompanied by marked inhibition of insulitis, which is not seen when either dietary agent is introduced alone.

Journal ArticleDOI
TL;DR: The predominance of PAOD in the lower leg of diabetic patients appears to be related to the presence of forefoot medial arterial calcification, and the underlying pathogenesis remains to be elucidated.

Journal ArticleDOI
TL;DR: The results suggest that diabetics with autonomic neuropathy might have abnormal control of respiration that is apparent only during sleep.

Journal ArticleDOI
TL;DR: Thioctic acid acts especially by increasing glucose uptake, glycogen breakdown and glucose oxidation, which means that metabolic and hemodynamic sequelae of insulin-deficiency in the heart can be corrected by TA.

Journal ArticleDOI
TL;DR: Findings indicated that the patients should be motivated adequately when they are diagnosed as having diabetes and subsequently encouraged to reinforce their intentions by the physician and co-medical staff and specific approaches suitable for each individual patient and not standardized guidelines should be devised.

Journal ArticleDOI
TL;DR: Results indicated that AO-128 retards the absorption of carbohydrate and reduces post-prandial hyperglycemia.

Journal ArticleDOI
TL;DR: Assessment of impaired glucose tolerance or gestational diabetes is a strong predictor for future development of non-insulin-dependent diabetes and should signal appropriate interventions to prevent or delay the progression to NIDDM.