Journal•ISSN: 1359-6446
Drug Discovery Today
Elsevier BV
About: Drug Discovery Today is an academic journal published by Elsevier BV. The journal publishes majorly in the area(s): Drug discovery & Medicine. It has an ISSN identifier of 1359-6446. Over the lifetime, 5445 publications have been published receiving 265287 citations.
Topics: Drug discovery, Medicine, Drug development, Drug delivery, Cancer
Papers published on a yearly basis
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TL;DR: The copper-(I)-catalyzed 1,2,3-triazole formation from azides and terminal acetylenes is a particularly powerful linking reaction, due to its high degree of dependability, complete specificity, and the bio-compatibility of the reactants.
2,882 citations
TL;DR: Polyethylene glycol-drug conjugates have several advantages: a prolonged residence in body, a decreased degradation by metabolic enzymes and a reduction or elimination of protein immunogenicity.
2,138 citations
TL;DR: The current status, strengths, and weaknesses of peptides as medicines and the emerging new opportunities in peptide drug design and development are discussed.
2,136 citations
TL;DR: Various screening approaches are being developed to improve the ease with which natural products can be used in drug discovery campaigns, and data mining and virtual screening techniques are also being applied to databases of natural products.
1,716 citations
TL;DR: Various endogenous factors that can positively impact the EPR effect in tumor tissues are discussed, as well as practical methods available in the clinical setting for augmenting the effect by use of exogenous agents.
1,701 citations