Showing papers in "Environmental Toxicology and Pharmacology in 2003"

TL;DR: There is little doubt that measurements of bioaccumulation and biomarker responses in fish from contaminated sites offer great promises for providing information that can contribute to environmental monitoring programs designed for various aspects of ERA.

TL;DR: The volcanic soil, fruit and vegetable samples of Van region in Eastern Turkey contain potentially carcinogenic heavy metals in such a high levels that these elements could be related to the high prevalence of upper GI cancer rates in Van region.

TL;DR: It has been concluded that exposure to Methyl Parathion has deleterious effects on male reproductive system of rat and application of such insecticide should be limited to a designed program.

TL;DR: A new class of potential pharmacological thiophenes and furans compounds has been prepared and all compounds displayed antioxidant activity however the anti-inflammatory activity is not related to antioxidant potential.

TL;DR: F fluoride causes excessive production of NO, LPO and oxygen free radicals, which can damage seriously the structure and function of soft tissues, and the mechanism of fluoride injuring soft tissues is suggested.

TL;DR: Evidence suggests that thiamine may partly act as an antioxidant to scavenge O(2)(-) (or OH) directly and thus affect the cellular response to oxidative stress induced by reactive oxygen species.

TL;DR: In the present study significantly increased lipid peroxidation value (LPP) after a single intraperitioneal injection of lead acetate (LA) indicated enormous generation of Reactive Oxygen Species (ROS).

TL;DR: Perinatal exposure to BPA caused the behavioral alterations in the offspring, and spontaneous activity analyses revealed that BPA elongated immobile time during the dark phase in female offspring.

TL;DR: The observed effects of mancozeb on testis and biochemical constituents may be due to hormonal imbalance in any of the stages in the hypothalamo-hypophysial-testicular axis.

TL;DR: H hepatopancreas of metal-exposed animals displayed non-specific, stress-indicating alterations such as cellular disintegration, the reduction of energetic reserves, electron dense cytoplasm, ultrastructural alterations of granular endoplasmic reticulum (GER), the Golgi complex and mitochondria.

TL;DR: It is concluded that SO(2) exposure can caused oxidative damage to brains and livers of mice, and SO( 2) is a toxin to brain and liver of mammals, not only to respiratory system.

TL;DR: Results call in question potential beneficial effects of dietary intake or therapeutic use of naturally occurring flavonoids, as quercetin, in a concentration range of 10-100 μM, but neither rutin nor the other two glycosides, were able to protect C6 cells from cytotoxicity and lipid peroxidation.

TL;DR: Effects of lethal and sublethal concentrations 15, 20, 26 and 35 μg/l of zeta cypermethrin on the gills of common guppies (L. reticulatus) were examined by light microscopy during 96 h exposure.

TL;DR: The effect that oral administration of four alkylphenols, BPA, OP, NP, p-nonylphenol and n-NP, as well as 17α-ethynylestradiol (EE2) had on male medaka fish vitellogenin was investigated.

TL;DR: It is concluded that NAC is effective for lowering chemical-induced elevated levels of SGPT and SGOT in the curative mode and against toxin-induced toxicity in the preventive tests.

TL;DR: The obtained data seem to validate the employment of the DSC technique in studying the ability of bioactive and potentially mutagenic compounds not only to interact with biological membranes but also to be adsorbed into a cell when dispersed in a lipophilic medium.

TL;DR: It is suggested that triple antioxidant therapy in diabetic volunteers attenuates the in vitro experimental oxidative stress of methaemoglobin formation and reduces haemoglobin glycation in vivo.

TL;DR: In this article, the pollution level of alkylphenolic compounds was measured and quantified in water, sediment, and the tissues of fishes collected in two rivers, Sakarya and Degirmendere Rivers, Turkey.

TL;DR: After reviewing the complex literature on the molecular and biochemical mechanisms of sex determination and differentiation in all vertebrates, the potential danger of environmentally induced sex determination will be focused on.

TL;DR: The results show that subchronic, low-level exposure by cadmium affects the rat's spontaneous and evoked bioelectric activity and point at the possible consequences in exposed humans.

TL;DR: Results suggest that intracellular Pb(2+) triggers apoptosis of rat thymocytes, and may be one of mechanisms for the lead-induced changes in immunity.

TL;DR: The results of the simultaneous measurements by both experimental procedures are reported for the first time and show that, while the cytotoxic effects of the two cadmium compounds are confirmed, the organic germanium compound reveals a very different and interesting interaction with Jurkart cells.

TL;DR: A series of N(1)-benzylidene pyridine-2-carboxamidrazone anti-tuberculosis compounds has been evaluated for their cytotoxicity using human mononuclear leucocytes (MNL) as target cells, suggesting that secondary mechanisms of toxicity were operating.

TL;DR: The activation of the compound to reactive species in vitro, the inhibitory effects of cimetidine in vivo and in vivo, as well as the rapid fall in the in vivo white cell count on rechallenge with aminoglutethimide suggest that this model illustrates a form of leucopenia which may be related to hapten formation and subsequent immune-mediated platelet and white cell lysis.

TL;DR: It is demonstrated that lead-induced morphological impairments of the rat Hi following developmental lead exposure follow a specific age- and site-related pattern.

TL;DR: The DHLA-mediated attenuation of daps one hydroxylamine-mediated methaemoglobin formation indicates a possible clinical application in high-dose dapsone therapy.

TL;DR: The results suggest that the measurement of cell proliferation in the auricular lymph node using BrdU immunohistochemistry could provide a reliable marker for MEST.

TL;DR: Findings suggest that tridecane exhibits greater permeability through skin among aliphatic and naphthalene among aromatic JP-8 components, and amount of chemicals absorbed suggests that tridescane, naphhalene and its methyl derivatives should be monitored for their possible systemic toxicity.

TL;DR: In conclusion, the investigated substances might possess weaker potency to elicit intranasal irritative effects than postulated.