Showing papers in "Epilepsy & Behavior in 2017"

TL;DR: Psychiatric and behavioral side effects occur more frequently in patients taking LEV and ZNS than any other AED and led to higher rates of intolerability, which may help facilitate the AED selection process.

TL;DR: Open-label studies with 100mg/ml CBD have provided additional evidence of its efficacy along with an adequate safety profile in children and young adults with a spectrum of TREs and Phase 3 RCTs with Epidiolex support efficacy and adequate safety profiles for children with DS and LGS.

TL;DR: The present review's findings aim to drive future drug development for newly-identified targets and indications, identify important limitations of animal models in the investigation of plant cannabinoid effects in the epilepsies, and focuses future research in this area on specific, unanswered questions regarding the complexities of endocannabinoid signaling in epilepsy.

TL;DR: As cannabinoids and cannabis-based products are studied for efficacy as anticonvulsants, more investigation is needed regarding the specific targets of action, optimal drug delivery, and potential drug-drug interactions.

TL;DR: This paper provides an up-to-date overview of the legal aspects of cannabis and cannabidiol, including cultivation, manufacture, distribution, and use for medical purposes, as of August 2016.

TL;DR: A logistic model looking at the individual impact of infantile spasms, seizure frequency, and age of seizures onset as predictors of developmental delay revealed that age of seizure onset was the most important factor in determining developmental outcome.

TL;DR: Some characteristics of DS such as gait issues increased with patient age, while others, including photosensitivity, hypotonia, and ataxia, were present from a young age, and some were correlated with SCN1A mutation status.

TL;DR: Resumption of research coupled with mass experimentation by families of epilepsy patients has led to intense interest in cannabis-based medicines for its treatment once more, with greatest focus on cannabidiol, but additional investigation of tetrahydrocannabinol, tetrahYDrocannabinolic acid, and other phytocannabinoids.

TL;DR: The processes of two institutions with extensive experience in producing large-scale cannabidiol chemotype Cannabis crops-GW Pharmaceuticals and the University of Mississippi-are described, including breeding, indoor and outdoor growing, harvesting, and extraction methods.

TL;DR: A retrospective study of characteristics associated with withdrawal due to psychiatric side effects was undertaken in patients with treated epilepsy participating in prospective audits with new antiepileptic drugs (AEDs), finding awareness of these issues may assist clinicians in avoiding, identifying and treating psychiatric comorbidities.

TL;DR: From ancient Chinese pharmacopeias to the current Phase III trials of pharmaceutical grade cannabidiol, this review covers the time span of cannabis use for epilepsy therapy so as to better assess the issues surrounding the modern medical opinion of cannabis Use.

TL;DR: The robust anticonvulsant effects of CBD may result from multiple pharmacological mechanisms, including facilitation of endocannabinoid signaling and TRPV1 mechanisms, with potential implications for the development of new treatments for certain epileptic syndromes.

TL;DR: Based on cases and previous data from animal experiments, BRV may prove useful in SE treatment, and trials would be warranted to examine BRV's efficacy in treating SE and how this efficacy might be influenced by co-administration with levetiracetam.

TL;DR: A "snapshot" of the clinical practices of experts in the treatment of epilepsy is provided, which suggests options that the clinician should consider to achieve best practice.

TL;DR: Cannabis may be considered as a risk factor of stroke until research shows evidence of an underlying mechanism that contributes to the development of stroke, as of today, reversible cerebral vasoconstriction triggered by cannabinoids use may be a convincing mechanism of stroke in 27% of cases.

TL;DR: A systematic review and meta-analysis identified potential risk factors for posttraumatic epilepsy and the results may contribute to better prevention strategies and treatments for PTE.

TL;DR: A meta-analysis evaluated the correlates of perceived stigma for epilepsy and found that results can serve as a basis for policymakers and healthcare professionals for formulating health promotion and prevention strategies.

TL;DR: This article reviews the Wistar Audiogenic Rat, a genetically selected reflex model susceptible to audiogenic seizures, and proposes that this strain be used in "omics" studies, as well as with the most advanced molecular and computational modeling techniques.

TL;DR: The findings support the notion that psychological factors are a stronger predictor of HRQoL in epilepsy and PNES than condition-related and demographic variables and highlight the importance of addressing patients' beliefs about their condition.

TL;DR: VNS for drug-resistant epilepsy is associated with improvement on various QOL metrics subjectively rated by physicians, suggesting satisfaction with therapy and favorable seizure outcome and a higher likelihood of generator replacement.

TL;DR: Findings with multimodal investigations of cerebral function concur to indicate that ictogenic mechanisms in IGEs largely (ab)use preexisting functional anatomic networks (CNS subsystems) normally serving highly complex physiological functions (e.g., deliberate complex actions and linguistic communication) which supports the concept of system epilepsy.

TL;DR: The findings suggest that the clinical characteristics and outcomes for pediatric patients were different from adult patients, and no significant differences were found among different immunotherapies.

TL;DR: Insight is provided into the use of cannabis products for epilepsy, in particular some of the likely factors influencing use, as well as novel insights into the experiences of and attitudes towards medicinal cannabis in people with epilepsy in the Australian community.

TL;DR: Prolonged exposure therapy for patients dually diagnosed with PNES and PTSD reduced the number of P NES and improved mood and post traumatic symptomatology and follow-up revealed that gains made in seizure control on the last day of treatment were maintained over time.

TL;DR: Rec retrospective data on efficacy and adverse effects of artisanal cannabis in Patients with medically refractory epilepsy with mixed etiologies in Washington State, California, and Maine is reported.

TL;DR: The number of online users interested in epilepsy is likely the highest among all neurological conditions, however, surgery, as a method of treating refractory epilepsy, could be underrepresented on social media.

TL;DR: Cardiac and pulmonary pathological abnormalities are frequent among SUDEP cases, most commonly pulmonary edema/congestion and focal interstitial myocardial fibrosis, and most findings are not quantified, with subjective elements and undefined interobserver reliability, and lack of controls such as matched epilepsy patients who died from other causes.

TL;DR: The more recent history and main experimental data for the Krushinsky-Molodkina audiogenic rat strain are presented, which is used not only as a genetic model of seizure states, but also as a model of blood flow disturbances in the brain.

TL;DR: How caution is needed in regards to rodent strain or even animal vendor choice, and how this can significantly influence seizure and epilepsy parameters in unexpected ways is discussed.

TL;DR: There is a strong association of SUDEP with sleep, suggesting that sleep is a significant risk factor for SUDEP.