Showing papers in "European Journal of Cancer in 2005"

TL;DR: Sufficient data currently exist to advocate phase II clinical evaluation of oral curcumin in patients with invasive malignancy or pre-invasive lesions of the gastrointestinal tract, particularly the colon and rectum.

TL;DR: Role of country, inclusion of controls with dermatological diseases and other study features seemed to suggest that "well conducted" studies supported the intermittent sun Exposure hypothesis: a positive association for intermittent sun exposure and an inverse association with a high continuous pattern of sun exposure.

TL;DR: The relationships between cancer and inflammation are discussed, and some of the molecular mechanisms involved in mediating the unintended consequences of host defense and tumour survival are discussed.

TL;DR: A systematic meta-analysis of observational studies of melanoma and one of the most important risk factors, the number of naevi, was conducted in order to clarify aspects of the aetiology of this disease.

TL;DR: A systematic meta-analysis of observational studies of melanoma and family history, actinic damage and phenotypic factors was conducted as part of a comprehensive meta- analysis of all major risk factors for melanoma.

TL;DR: This review shows that focusing on the long-term effects of breast cancer is important when evaluating the full extent of cancer treatment, and the current medical condition, amount of social support and current income level were strong positive predictors of quality of life.

TL;DR: Members of the Fos family (c-Fos, FosB and its smaller splice variants, Fra-1 and Fra-2) dimerise with Jun proteins to form the AP-1 transcription factor complex and the results obtained show different implications according to tumour type.

TL;DR: There is growing evidence that some Sp proteins play a critical role in the growth and metastasis of many tumour types by regulating expression of cell cycle genes and vascular endothelial growth factor.

TL;DR: Some evidence is found suggesting confounding due to incomplete adjustment for breast cancer risk factors, with smaller effects in the studies that more completely adjusted for reproductive history and other confounding factors.

TL;DR: Improved understanding of the molecular basis of cancer will provide new possibilities for: (1) earlier detection as well as better diagnosis and staging of disease with detection of minimal residual disease recurrences and evaluation of response to therapy; (2) prevention; and (3) novel treatment strategies.

TL;DR: The development of a patient self-report questionnaire, the CIPN20, intended to supplement the core quality of life questionnaire of the European Organization for Research and Treatment of Cancer (EORTC), is reported on.

TL;DR: Chemopreventive activities observed with these compounds relevant to inhibition of carcinogenesis at the initiation, promotion and progression phases, as well as results from in vivo studies on metabolism, bioavailability and efficacy are summarised in this review.

TL;DR: Inflammatory cell response at the invasive border is a relevant prognostic indicator and could be easily incorporated into the routine evaluation of histopathological specimens.

TL;DR: It is concluded that a cross-over to high-dose imatinib is feasible and safe in GIST patients who progress on low-dose therapy.

TL;DR: Several families of transcription activators and repressors that catalyse histone post-translational modifications (acetylation, methylation, phosphorylation, ubiquitination and SUMOylation) are focused on; and how these enzymatic activities might alter the correct cell proliferation program, leading to cancer.

TL;DR: The frequency of PIK3CA mutations in exons 9 and 20 that has previously been reported as mutational hotspot regions in distinct tumour models are determined and the association between PIK2CA mutations and KRAS or BRAF mutations is analysed.

TL;DR: The goal of these guidelines is to encourage transparent and complete reporting so that the relevant information will be available to others to help them to judge the usefulness of the data and understand the context in which the conclusions apply.

TL;DR: With gradual Westernisation, many Asian countries may be losing their cultural protective factors and acquiring high- risk ones, and a better understanding of how these factors interact to cause prostate cancer through further studies with a multi-ethnic perspective will facilitate appropriate public health strategies to minimise high-risk factors and maintain Protective factors and keep prostate cancer at bay.

TL;DR: The reported incidence of GIST and GIST-like tumours before and after the routine availability of the specific diagnostic marker CD117 antigen was investigated and it was indicated that almost 50% of the GIST was considered to be at high-risk for malignant behaviour according to the consensus criteria.

TL;DR: A retrospective analysis of a prospectively maintained database of soft tissue sarcoma patients treated at the Royal Marsden Hospital suggests that myxoid liposarcoma is relatively chemosensitive in comparison to a combination of other liposARcomas, and in particular de- and well-differentiated tumours.

TL;DR: The results demonstrate that the prognosis of TNM stage II colorectal cancer is dependent on the number of lymph nodes examined, and it can be presumed that those patients with stage II tumour with only a few nodes examined should be offered postoperative chemotherapy on a routine basis.

TL;DR: This systematic review examined evidence from published manuscripts looking at molecular markers in pancreatic cancer and their correlation with tumour stage and grade, response to chemotherapy and long-term survival.

TL;DR: The approach of the Clinical Trials Group of the National Cancer Institute of Canada emphasises the clinical meaning of the results, while avoiding complex statistical modelling.

TL;DR: It is indicated that low levels of circulating 25(OH)D, both alone and in combination with BsmI VDR genotype, may increase risk of breast cancer in a UK Caucasian population.

TL;DR: The trisubstituted acridine based TTA, BRACO19, has demonstrated single agent activity against human tumour xenografts with anti-tumour effects apparent from only 7 days of treatment.

TL;DR: The currently available literature provides tantalising hints of the potential usefulness of anthocyans or anthocyan mixtures as cancer chemopreventive interventions, but further studies are necessary to help adjudge the propitiousness of their clinical development.

TL;DR: A meta-analysis of aspirin, beta-carotene, calcium, and wheat bran studies suggests that rodent models roughly predict effect in humans, but the prediction is not accurate for all agents.

TL;DR: Lipogenic enzymes are markedly induced in hepatocellular carcinomas, and in some cases SREBP-1c is involved in this activation.

TL;DR: The age-specific prevalence of serious comorbidity among all new breast cancer patients diagnosed from 1995 to 2001 in the South of the Netherlands was analysed in relation to age, stage and treatment.

TL;DR: The data support the hypothesis that hyperinsulinaemia is a promoter of clinical prostate cancer and suggest that the insulin level could be used as a marker of prostate cancer prognosis and tumour aggressiveness, regardless of the patient's prostate cancer stage, cancer grade and PSA level.