Showing papers in "European Journal of Cancer in 2010"

TL;DR: The statistical models used used to estimate incidence and mortality data for 25 cancers in 40 European countries in 2008 used to obtain an estimate of the numbers of cancer cases and deaths in Europe in 2008.

TL;DR: The working group strongly suggests that all breast cancer specialists cooperate for an optimal clinical use of this emerging technology and for future research, focusing on patient outcome as primary end-point.

TL;DR: The fusion between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) has recently been identified in a subset of non-small cell lung cancers (NSCLCs).

TL;DR: Alternative strategies targeting CD44 functions include the binding to hyaluronan (HA), the collaboration with osteopontin and the contribution of CD44 isoforms to receptor tyrosine kinase (RTKs) activation.

TL;DR: There is strong and consistent evidence that physical activity reduces the risk of several of the major cancer sites, and that between 9% and 19% of cancer cases could be attributed to lack of sufficient physical activity in Europe.

TL;DR: Addition of adjuvant chemotherapy to radiation improves progression-free survival in operated endometrial cancer patients with no residual tumour and a high-risk profile.

TL;DR: The role of diabetes mellitus type 2 and insulin resistance in carcinogenesis, the preclinical rationale and potential mechanisms of met formin's anti-cancer effect and the current and future clinical developments of metformin as a novel anti- cancer drug are discussed.

TL;DR: Margin status has a prognostic effect in all women treated for invasive breast cancer; increasing the threshold distance for declaring negative margins is weakly associated with reduced odds of LR, however adjustment for covariates (adjuvant therapy) removes the significance of this effect.

TL;DR: The main findings observed to date from the European Prospective Investigation into Cancer and Nutrition on dietary factors associated with the most frequent cancer sites contribute to scientific evidence for appropriate public health strategies and prevention activities aimed at reducing the global cancer burden.

TL;DR: Recommendations on CM diagnosis and treatment are made based on systematic literature reviews and the experts' experience, with a clear survival benefit and the presence of toxicity limit its use in practice.

TL;DR: The potential contribution of interactions between tumour cells and the microenvironment in metastatic sites, in regulating tumour dormancy vs. metastatic growth is reviewed, particularly on the potential role of the extracellular matrix (ECM) in regulating maintenance and release from dormancy.

TL;DR: The current literature describing the impact of miRNAs on prediction and modification of anticancer treatment including the possible intracellular pathways involved in these processes is summarized.

TL;DR: The contribution of interleukin-6 (IL-6) produced in the bone marrow microenvironment to bone metastasis is reviewed, which has a strong pro-tumorigenic activity due to its multiple effects on bone metabolism, tumor cell proliferation and survival, angiogenesis, and inflammation.

TL;DR: This study confirmed the association between MSI and favourable prognosis as determined by both OS and DFS of CRC patients and proposed that this inconclusive result is due to the use of a single marker, such as MSI, that cannot account alone for the complexity of the mechanisms underlying 5-FU cytotoxicity.

TL;DR: Prostate cancer mortality has been decreasing in 13 of the 37 European countries considered - predominantly in higher-resource countries within each region - beginning in England and Wales (1992) and more recently in the Czech Republic (2004).

TL;DR: Autophagy was activated as a protective mechanism against 5-FU-induced apoptosis and its inhibition could be a promising strategy for adjuvant chemotherapy in colon cancer.

TL;DR: The purpose of this paper is to focus on the influence of age on cancer presentation and cancer management in older cancer patients and to provide suggestions on clinical trial development and methodology in this population.

TL;DR: The QLQ-BN20 demonstrates adequate psychometric properties and can be recommended for use in conjunction with the QLq-C30 in assessing the HRQOL of brain cancer patients in international studies.

TL;DR: Despite an overall good QoL, colorectal cancer survivors have specific physical and psychological problems, and further studies are needed that focus on problems like distress, depression and bowel problems of long-term colorective cancer survivors.

TL;DR: periodic monitoring of urinary protein should be carried out in anti-VEGF-treated patients and patients showing proteinuria need special referral to nephrologists, because there are no controlled studies addressing the subject.

TL;DR: The treatment of breast cancer in pregnancy should be executed by experienced specialists in a multidisciplinary setting and should adhere as closely as possible to standard protocols.

TL;DR: In this review, the available data regarding the different tools used to assess CIPN will be revised and their features will be critically examined, with a special focus on their reliability and reproducibility across examiners and, when available, through direct comparison.

TL;DR: The results suggest that miR-101 may function as a tumour suppressor in gastric cancer, as it has an inhibitory role not only in cellular proliferation, migration and invasion in vitro, but also in tumour growth in vivo.

TL;DR: OC users carrying an ascertained BRCA1/2 mutation have a reduced risk of ovarian cancer, proportional to the duration of use, and there is no evidence that recent OC formulations increase breast cancer risk in carriers.

TL;DR: Predictive factor analysis showed that compared to doxorubicin monotherapy, patients who benefited less from ifosfamide-based therapies were leiomyosarcoma patients in terms of OS, and patients with liposARcoma for response, and no predictive factors were found for PFS.

TL;DR: While case-control studies with measurement of 25(OH)D after diagnosis suggest an inverse association, a statistically significant inverse association remained unconfirmed in prospective studies with measured levels years before diagnosis and further studies are needed to clarify the potential role and the relevant exposure time regarding vitamin D and breast cancer risk.

TL;DR: BRAF genotype is correlated with PFS and OS in KRAS wild type mCRC patients, which is independent of cetuximab treatment, and PIK3CA mutation, loss of PTEN expression, EGFR GCN and HER2 GCN have no predictive value for response to treatment with cetUXimab, neither individually nor in combination with other markers.

TL;DR: The main challenges facing the effective use of HGF/Met-targeted antagonists for cancer treatment include optimal patient selection, diagnostic and pharmacodynamic biomarker development, and the identification and testing of optimal therapy combinations.

TL;DR: A quite consistent trend was observed favouring individuals with a high SES compared to those with a low SES that still remains in terms of treatment, survival and thus also mortality, which needs to be met to meet increasing inequalities in mortality from CRC in Europe.

TL;DR: The specific challenges in pushing the boundaries of NPC treatments further are discussed, with an emphasis on prognostic/predictive markers, molecularly targeted therapies, immunotherapies and the areas of interest with regard to long-term toxicities arising from therapeutic interventions.