Showing papers in "European Journal of Cancer in 2013"

TL;DR: Up-to-date estimates of the cancer burden in Europe alongside the description of the varying distribution of common cancers at both the regional and country level provide a basis for establishing priorities to cancer control actions in Europe.

TL;DR: This review focuses on roles in cancer cell-tumour microenvironment interaction and summarises strategies for treating cancer by disrupting this interaction with special emphasis on the CXCR4/CXCL12 axis.

TL;DR: The importance of strengthening screening efforts and augmenting existing cancer control efforts with HPV vaccination is underscored, notably in those countries where unfavourable cohort effects are continuing or emerging.

TL;DR: Although no significant difference in OS was observed in this study, extensive crossover from placebo to pazopanib confounded final OS analysis and post-hoc analyses adjusting for crossover suggest OS benefit with pazobanib treatment for mRCC patients.

TL;DR: Interestingly, programmed death receptor ligand 1 (PDL-1) and interferon (IFN)-γ gene expression, as detected by quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in fresh frozen CRC specimens were found to be significantly associated with improved survival in MMR-proficient CRC.

TL;DR: VTE is strongly linked to cancer, but the annual rate varies greatly by cancer site, proximity to diagnosis and age, so prophylaxis guidelines should take account of cancer site and such intervention should also be targeted towards the three months following diagnosis.

TL;DR: relevant aspects of MAP kinase pathway signalling are described, clinical data with BRAF and MEK inhibitors are summarised, known resistance mechanisms to BRAF inhibitor therapy are presented, and some strategies for how resistance may be overcome are provided.

TL;DR: Combined data from HPV-DNA and p16(INK4a) testing are likely to represent a closer estimate of the real fraction of IVC induced by HPV, indicating that HPV contribution in invasive vulvar cancer has probably been overestimated.

TL;DR: Genome-wide profiling revealed that MALAT-1 and prostate cancer gene 3 (PCA3) are overexpressed in PCa tissues and MD-miniRNA can be used as a novel plasma-based biomarker for PCa detection and can improve diagnostic accuracy by predicting prostate biopsy outcomes.

TL;DR: Prophylactic treatment with dexrazoxane, beta-blocker, statin or angiotensin antagonists appear to have similar efficacy for reducing cardiotoxicity.

TL;DR: These nationwide data provide an up-to-date survey of the epidemiology of ACC in the Netherlands and a trend towards a decreasing overall incidence rate was observed, despite an increased number of surgical procedures.

TL;DR: FITs can detect much larger proportions of colorectal neoplasms even if their cut-offs are set to levels that ensure equally low positivity rates as gFOBT, according to a head-to-head comparison among participants of the German screening colonoscopy programme.

TL;DR: Regorafenib had acceptable tolerability and evidence of antitumour activity in patients with intermediate or advanced HCC that progressed following first-line sorafen ib.

TL;DR: The study provides further evidence for the hypothesis that the length of the diagnostic interval affects mortality negatively and finds increasing mortality with longer diagnostic intervals among the approximately 40% of the patients who presented in primary care with symptoms suggestive of cancer or any other serious illness.

TL;DR: The hypothesis that TNBC exosomes may be involved in cancer cell-to-cell communication, conferring phenotypic traits to secondary cells that reflect those of their cells of origin is supported.

TL;DR: A retrospective-prospective cohort study on borderline ovarian tumours to better understand BOT and identify scenarios in which future studies could be developed revealed higher stage, incomplete staging, tumour residuals, and organ preservation as independent prognostic factors for disease recurrence.

TL;DR: The increasing incidence of NET (without G3-SCNEC) was mainly due to the increase of G 3-LCNEC, related to improved diagnostic procedures and to shifting in pathology from other entities (such as undifferentiated carcinoma) to NET.

TL;DR: The results indicate that microRNAs show promising associations with prognosis in lung cancer; moreover, specific micro RNAs such as miR-21 andMiR-155 can predict recurrence and poor survival in NSCLC.

TL;DR: Substantial preclinical evidence for cross-resistance between the taxanes docetaxel and cabazitaxel, and AR targeting agents abiraterone and enzalutamide is found.

TL;DR: VM-positive cancer patients show a poor 5-year overall survival compared with VM-negative malignant tumour cases, particularly in metastatic cancer, suggesting that VM contributes to tumour metastasis and poor prognosis in cancer patients.

TL;DR: Even in these patients with tumours of excellent prognosis, LR after conservative surgery without adjuvant therapy was still very high and was reduced to a similar extent by either radiotherapy or tamoxifen but to a greater extent by the receipt of both treatments.

TL;DR: The data indicate that serum miR-1 is a new independent parameter of OS in HCC patients and may therefore improve the predictive value of classical HCC staging scores.

TL;DR: Up-dated and revised guidelines on the requirements of a Specialist Breast Centre (BC) are produced, based on evidence from the recent relevant peer reviewed literature and the consensus of a multidisciplinary team of European experts.

TL;DR: Variant UCB histologies were associated with features of biologically aggressive disease, and was associated with worse outcomes in univariable analyses, but this effect did not remain significant in multivariable analysis.

TL;DR: The combination of cediranib and olaparib has haematologic DLTs and anticipated class toxicities, with promising evidence of activity in ovarian cancer patients.

TL;DR: It is shown that high numbers of CD8(+) tumour infiltrating lymphocytes (TILs) in HPVDNA+ p16(INK4a+) TSCC indicated a better outcome in patients with human papillomavirus positive tonsillar and base of tongue squamous cell carcinoma, and could be used when selecting patients for more individualised treatment.

TL;DR: Adding aflibercept to gemcitabine did not improve OS in patients with metastatic pancreatic cancer and was stopped for futility following a planned interim analysis of OS.

TL;DR: The study findings suggest VaL to be a non-toxic and effective second-line therapy that offers a prolongation of OS as well as less disease-related symptoms for patients with locally advanced or metastatic pancreatic cancer.

TL;DR: The study findings confirmed, in Italy, the increased risks for cancer following KT, and they also suggested a possible protective effect of mTORi in reducing the frequency of post transplant cancers.

TL;DR: Low-dose metronomic chemotherapy appears to be clinically beneficial and safe in a broad range of tumors, however, meta-regression analysis did not identify predictive factors of response.