Showing papers in "European Journal of Cancer in 2021"

TL;DR: The most common causes of cancer deaths are: lung (380,000), colorectal (250,000, breast (140,000) and pancreatic (130,000); these four cancers account for half the overall cancer burden in Europe as mentioned in this paper.

TL;DR: In this article, the safety and activity of preoperative pembrolizumab combined with chemoradiotherapy for resectable oesophageal squamous cell carcinoma (ESCC) were investigated.

TL;DR: The European Association of Nuclear Medicine (EANM) Focus 3 performed a multidisciplinary Delphi process to deliver a balanced perspective on molecular imaging and radionuclide therapy in well-differentiated neuroendocrine tumours (NETs).

TL;DR: In this article, the authors assessed the immunologic response after COVID-19 vaccination of cancer versus non-cancer population and found that patients with cancer had a significantly lower seroconversion rate than those with solid tumours after complete immunisation.

TL;DR: Cumulative exposure to corticosteroids, antibiotics and PPIs (three likely microbiota-modulating drugs) leads to progressively worse outcomes after ICI therapy, and a simple prognostic score is proposed that can help stratifying patients in routine practice and clinical trials of ICIs.

TL;DR: The composition, function and prognostic value of tumour-infiltrating lymphocytes (TIL) in neuroblastoma is discussed, as well as opportunities for immunotherapy and future perspectives with regard to state-of-the-art developments in the tumour immunology space are highlighted.

TL;DR: The NAVIGATOR (NCT02508532) study as discussed by the authors, a two-part, open-label, dose-escalation/dose-expansion phase I study, enrolled adult patients with unresectable GISTs.

TL;DR: In this article, the authors systematically analyzed the current state of research on reader studies involving melanoma and assessed their potential clinical relevance by evaluating three main aspects: test set characteristics (holdout/out-of-distribution data set, composition), test setting (experimental/clinical, inclusion of metadata) and representativeness of participating clinicians.

TL;DR: Clinicians and cancer researchers utilise exosome's benefits through randomised clinical trials for better management of breast cancer.

TL;DR: In this paper, the integrative recommendations for BRCA testing presented here aim to identify individuals who may benefit from genetic counselling and risk-reducing strategies; update germline and tumour-testing indications for PARPi-approved therapies; and provide testing recommendations for personalised management of early and metastatic breast cancer.

TL;DR: In this paper, a review of the current knowledge about how selenium stimulates the immune system against cancer and lay the groundwork for future research is presented, which can be promising to design combinatorial therapies with Selenium-based compounds and other modalities like immunotherapy to lower the adverse effects and increase the efficacy of treatments.

TL;DR: In this paper, the authors conducted an up-to-date and comprehensive meta-analysis including recently published data of phase III clinical trials evaluating immune-based combinations in metastatic renal cell carcinoma (mRCC).

TL;DR: In this article, the authors developed evidence-based expert recommendations on categories for extent of resection based on a comprehensive literature review, and formulated for the categories "biopsy", "partial resection", "subtotal resection" and "supramaximal resection".

TL;DR: In this paper, the authors used a time-dependent analysis to assess the potential association between late-onset and long-lasting irAEs and overall survival (OS) in all registration trials leading to ICI's approval by US FDA and/or EMA up to December 2019.

TL;DR: In this paper, the effects of COVID-19 vaccines and immunization rates in patients with cancer were investigated in a phase 3 randomised clinical trial and the authors concluded that the benefits of the vaccination outweigh the risks.

TL;DR: In this paper, the authors developed and validated a deep learning radiomic nomogram (DLRN) for pre-operatively assessing breast cancer pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) based on the pre- and post-treatment ultrasound.

TL;DR: In this paper, the authors systematically searched for randomised trials comparing neoadjuvant therapy with upfront surgery for resectable and borderline resectably pancreatic cancer published since database inception until December 2020.

TL;DR: In this article, the compliance with the COVID-19 vaccine of patients affected by solid tumours was reported, and the most frequent reasons reported were concerns about vaccine-related adverse events (481%), negative interaction with concomitant antitumor therapy (267), and the fear of allergic reaction (107%).

TL;DR: A systematic review of recent studies reporting CNN-based approaches for digital biomarkers for characterization and prognostication of gastrointestinal cancer pathology is presented in this paper, where the authors identified several studies demonstrating generalization of the classifier with external tests and comparisons with pathologists, but none presenting clinical implementation.

TL;DR: In this article, CXCL13 transcript expression was used as a biomarker of TLS in muscle-invasive bladder cancer (MIBC) patients with ICI-tolerant patients.

TL;DR: It is shown that statin use is associated with better clinical outcome in MPM and aNSCLC patients treated with PD-1 inhibitors in an intensity-dependent manner and better PFS in a NSCLC.

TL;DR: Tocilizumab was a well-tolerant and effective steroid-sparing treatment for both management of irAEs, as well as prevention of flare of pre-existing auto-immune disorders.

TL;DR: In this paper, the authors performed a systematic review using MEDLINE, Embase and Cochrane Central Register of Controlled Trials to assess the activity of ICPIs in the treatment of soft-tissue sarcomas.

TL;DR: This review provides an overview of the major principles of single-cell and conventional (bulk) RNA-seq applied to onco-immunology and gives examples of machine and deep learning models used to predict patient outcomes and treatment effect from high-dimensional data.

TL;DR: In an open-label study, patients with early cervical carcinoma (FIGO 2009 stage IA2 to IIA1) were randomly assigned to Sentinel node (SN) resection alone (SN arm) or pelvic lymph node dissection (SN+PLND arm).

TL;DR: In this paper, the long-term safety of pembrolizumab in melanoma was analyzed in a large-scale clinical trial with 1567 patients who received ≥ 1 pembroximab dose.

TL;DR: Poziotinib exhibited effects in mNSCLC patients with EGFR/HER2-exon 20-i-mut, and the toxicity rate was high leading to frequent dose interruption and reduction, thereby reducing mPFS in patients with good ORR/DCR.

TL;DR: A review of the most widely studied natural compounds and their molecular mechanisms for chemoprevention of cancer can be found in this article, where the authors critically review these promising new natural compounds, their molecular targets and mechanisms of anticancer activity that may create novel opportunities for further design and conduct of preclinical and clinical studies.

TL;DR: In this paper, the authors examined the safety and efficacy of COVID-19 vaccines in patients with cancer and found that the first and second doses yielded weaker and heterogeneous serological responses in both patients with hematological and solid malignancies.

TL;DR: A review of the breast cancer vaccine landscape can be found in this paper, where gene-based and viral vector-based platforms have been used to develop breast cancer vaccines and lipid nanoparticles proved to be immunogenic and efficient delivery vehicles.