Showing papers in "European Journal of Cell Biology in 2006"

TL;DR: The vast range of activities of hyaluronan polymers is reviewed here, in order to determine if patterns can be detected that would provide insight into their production and regulation.

TL;DR: The role of the distance between integrin ligands, namely the RGD (arginine-glycine-aspartate) sequence present in ECM proteins, in the control of cell adhesion is illustrated and indicates that not only the composition, but also the spatial organization of the extracellular environment is important in regulating cell-ECM interactions.

TL;DR: To understand the specific properties and relationship of podosomes and the sealing zone, live-cell imaging of cultured osteoclasts was used and it appears that podosome belt is strikingly linked.

TL;DR: The roles of myofibroblast adhesions in sensing matrix stress, in transmitting contractile force to the extracellular environment and in creating the high intracellular tension that is required for myofIBroblast development are discussed.

TL;DR: The proposed thermodynamic model predicts that formin-mediated actin polymerization should be greatly enhanced by application of external pulling force, and suggests a novel mechanism of such "leaky" capping based on an assumption of elasticity of the formin/barbed end complex.

TL;DR: The results with respect to the importance of ID junction molecules for the formation, maintenance and function of the heart are discussed, particularly in relation to recent findings that deletions of - or mutations in - genes encoding such proteins can cause severe, sometimes lethal damages.

TL;DR: These findings demonstrate that it may be possible to differentiate MSC into therapeutically useful cells for clinical applications and myelinating capacity, and in some cases, single tMSC were able to myelinate more than one axon.

TL;DR: The results suggest that vinculin inhibits cell migration by stabilising FAs, and that binding of inositol phospholipids to Vt plays an important role in FA turnover.

TL;DR: In this article, the chemotactic response of Dictyostelium discoideum cells to stationary, linear gradients of cyclic adenosine 3',5'-monophosphate (cAMP) was studied using microfluidic devices.

TL;DR: It is demonstrated that AKAP79/150 is targeted to dendritic spines by an N-terminal basic region that binds phosphatidylinositol-4,5-bisphosphate (PIP(2)), F-actin, and actin-linked cadherin adhesion molecules, and challenge the accepted notion thatAKAPs are static anchors that position signaling proteins near fixed target substrates.

TL;DR: A model for possible functions and interactions of invadopodia and podsomes in tumor invasion is proposed, based on observations that macrophage podosomes degrade ECM and that podosome formation is regulated by colony-stimulating factor-1 signaling.

TL;DR: The predominant type of adhering junction present in IDs is a junction sui generis, termed area composita, that is characterized by an unusually high molecular complexity and an intimate association of molecules of both ensembles, the desmosomal one and the fascia adhaerens category.

TL;DR: This article considers recent advances in the understanding of the adhesive and motile behaviour of macrophages and DC, with particular emphasis on the podosomes that appear to be required for normal migration through extracellular matrices.

TL;DR: Light is shed on the mechanism by which eukaryotic cells maintain cell polarity and directed cell movement, and it is demonstrated that multiple steps in the signal transduction pathway coordinately regulate cell motility.

TL;DR: Gap junctional Integration of signals is important in load response of tenocyte populations - mechanotransduction occurs in individual cells but integration of signals markedly enhances it and communication via connexin 32 and 43 have differential effects on the load response.

TL;DR: This work demonstrates the capability of MSCs for transendothelial migration and shows that the vast majority of M SCs migrated within 30 min, an important finding for the exposure times in clinical settings.

TL;DR: This review will focus on the signal transduction pathways that regulate myosin II during cell movement, and the formation of bipolar filaments and their translocation to the cortex are separate events.

TL;DR: This review will address recent advances in the understanding of bacterial engagement of cellular adhesion molecules by discussing the binding of integrins by Staphylococcus aureus as well as the exploitation of IgCAMs by pathogenic Neisseria species.

TL;DR: An extensive morpho-functional analysis of invadopodia actively engaged in ECM degradation is presented and it is shown that they are actin comet-based structures, not unlike the well-known bacteria-propelling actin tails.

TL;DR: A better understanding of the distinctive role that individual PDEs play in shaping the cAMP signal in heart cells may lead to the development of new strategies for selective pharmacologic manipulation of cAMP signalling in defined functional domains.

TL;DR: Considering the substantial interest and momentum in the field, the need for an operational framework to correctly define and identify invadopodia will be discussed and some of the most important open questions in invadobodia biology will be reviewed.

TL;DR: The existence of the latter three types of receptors in D. discoideum was surprising because they had not been observed outside the animal kingdom before and their presence suggests unprecedentedly complex and so far unknown signaling activities in this lower eukaryote.

TL;DR: Recent data on genes and pathways governing directional sensing and actin polymerization in chemotaxis are discussed, with a particular emphasis on contributions from the laboratory.

TL;DR: Analysis of the mAKAP complex illustrates how a macromolecular complex can serve as a node in the intracellular signaling network of cardiac myocytes to integrate multiple cAMP signals with those of calcium and MAP kinases to regulate the hypertrophic actions of several hormones.

TL;DR: This review highlights some of the novel results recently obtained that raise the possibility of a pivotal role for Rap1 in the functional crosstalk between cadherins and integrins, suggesting interesting new regulatory mechanisms.

TL;DR: This work highlights the recent findings on α and βPIX and their involvement in integrin-dependent signaling and suggest models for the role of PIX proteins during focal adhesion turnover and highlights the importance of knowing the carrier and removal status of these proteins.

TL;DR: An inventory of proteins involved in Rho-regulated signaling pathways in Dictyostelium discoideum that have been identified in the completed genome sequence is presented.

TL;DR: By in vitro analysis, it is shown that, similar as in vertebrates, the single PDZ domain of Drosophila DmPar-6 can bind to the four C-terminal amino acids of the transmembrane protein Crumbs and that the cytoplasmic domain of Crumbs can recruit Dm Par-6 and DaPKC to the plasma membrane.

TL;DR: Results suggest that H/R induces activation of MEK/ERK and PI3K/Akt/XIAP survival signaling pathways through the reactive oxygen species-dependent EGFR/Ras/Raf cascade.

TL;DR: There was morphological as well as immunohistochemical evidence for a transdifferentiation within the host tissue and BMSCs could be efficiently transduced using a third-generation adenoviral vector, indicating their potential feasibility for a gene-therapeutic option.