Showing papers in "European Journal of Cell Biology in 2008"

TL;DR: It is proposed that different integrins use different mechanisms to activate latent TGF-beta1, and this opens new possibilities to develop cell-specific therapeutic strategies for TGF -beta1-induced pathologies.

TL;DR: The output of this entire regulatory system, in combination with spatial and temporal segregation of the activation mechanisms, underlies the contribution of ADF/cofilins to various cell migration/invasion phenotypes.

TL;DR: New data are presented showing that cortactin is essential for both the localization of key invadopodia matrix metalloproteinases to actin-positive puncta at the cell-ECM interface and for ECM degradation induced by overexpression of MT1-MMP-GFP.

TL;DR: Comparing recent advances and developments in the elucidation of the organization and dynamics of focal adhesion and podosome-type adhesions is compared in order to understand how such subcellular sites - though closely related in their composition - can be structurally and functionally different.

TL;DR: Evidence indicating that tumor cell invasiveness is associated with increased contractile force generation is discussed, and recently developed biophysical tools are described, including 2-D and 3-D traction microscopy to measure contractile forces of cells.

TL;DR: The dynamic actin remodelling in osteoclasts appears then as a major factor to understand their unusual abilities reminiscent of metastatic tumour cells.

TL;DR: Recent advances made in understanding of podosome arrangements in osteoclasts are considered and how Rho GTPases may control it is considered.

TL;DR: It is reported that in the adult hearts of diverse lower vertebrates (fishes, amphibia, birds) most AJs remain separate and distinct in molecular character, representing either fasciae adhaerentes, maculae adhaerences (desmosomes) or--less frequently--some form of AC.

TL;DR: It is demonstrated that decreased expression of Tks5 correlated with reduced tumor growth at this site, which potentially implicate a novel role of podosomes as mediators of tumor angiogenesis and support further exploration of how podosome formation and Tk5 expression contribute to tumor progression.

TL;DR: The non-proteolytic function of uPAR is focused on as a mediator of cell adhesion and downstream signalling in the extracellular matrix.

TL;DR: The human neutrophil nucleus appears to be highly specialized, possessing a paucity of nuclear envelope-stabilizing proteins, resulting in the nucleus appearing to be very malleable, supporting rapid migration through tight tissue spaces.

TL;DR: It is shown that trafficking of reggie-1/flotillin-2 is BFA sensitive and that deletion mutants of reggies/ flotillins accumulate in the Golgi complex in HeLa, Jurkat and PC12 cells, suggesting Golgi-dependent trafficking ofreggie- 1/flotsillins-2.

TL;DR: Two additional, extracellular mechanisms by which NHE1 activity contributes to cell migration and invasion are focused on.

TL;DR: The importance of caveolin-1 has recently been reinforced by studies with Cav1(-/-) cells, which indicate that it establishes polarity during directional migration by coordinating Src kinase and Rho GTPase signalling.

TL;DR: It is demonstrated how cell morphology, adhesion area, actin and vinculin distribution as well as cell body polarisation are influenced by the peptide patch spacing gradient.

TL;DR: Studies in a variety of cultured cells suggest that the actin-organizing activity of palladin plays a central role in promoting cell motility, and relative evidence also supports this hypothesis.

TL;DR: It is demonstrated that Rsu-1 links the Ras pathway with the IPP complex and the perturbations of cell attachment-dependent signaling that occur in the malignant process and that Ras activation perturbs this inhibitory function by modulating both RSU-1 splicing and association of full-length Rsu1 with IPP.

TL;DR: Observations indicate that lamin A/C deficiency causes not only reorganization of chromatin and some chromatin-associated domains, but also has an impact on the extent of chromosome condensation.

TL;DR: It is reported that human PCs express chemokine receptors, present their profile, and demonstrate a dose-dependent migratory effect of distinct chemokines on these cells, which are promising towards in situ bone repair therapies based on guiding PCs to bone defects.

TL;DR: Activation of Epac1 and PKA by cAMP results in the stimulation of two parallel, independent signaling pathways that positively regulate endothelial integrity and cell migration, which is important for recovery after endothelial damage and for restoration of compromised endothelial barrier function.

TL;DR: The present review focuses on the mechanisms regulating Hck activity as well as on the functions of Hck isoforms in phagocytes, and presents selected examples of Hk substrates and/or adaptors shown to interact with the kinase in myeloid cells.

TL;DR: It is reported that plakophilin-2 is indeed of obvious importance for myocardial architecture and cell-cell coupling of rat cardiomyocytes growing in culture and that numerous variously sized vesicles appear, which are plaque protein-associated as demonstrable by immunofluorescence and immunoelectron microscopy.

TL;DR: A promoting effect of 5-azacytidine on the expression of muscle-specific proteins and genes in BMSC in culture is demonstrated, demonstrating that priming of mesenchymal cells to cardiomyogenic differentiation may have significant applications in cellular approaches to ameliorate muscle loss after myocardial ischemia.

TL;DR: It is shown that, by acting at the membrane, Tat induces IL-10 expression in primary monocytes and promonocytic U937 cells by NF-kappaB-dependent pathways.

TL;DR: In this paper, a trans-negative reggie-1/flotillin-2 deletion mutant, R1EA, was found to interfere with oligomerization of the reggies and flotillins, inhibited insulin-like growth factor (IGF)-induced neurite outgrowth in N2a neuroblastoma cells and impaired in vitro differentiation of primary rat hippocampal neurons.

TL;DR: It is shown that in insulinoma INS-1 cells ICA69 binds to the small GTPase Rab2, which regulates the transport of COPI vesicles between the endoplasmic reticulum and the Golgi complex and point to its role in regulating the early transport of insulin secretory granule proteins.

TL;DR: HSP27 can enhance cell adhesion and modulate cell migration and invasion via the coordination of FAK-dependent actin organization and STAT3-dependent MMP-2 expression, and that phosphorylation of HSP27 is indispensable to regulate this signal pathway.

TL;DR: New insights into the interplay between TRP channels and the cytoskeleton are discussed and recent examples of such interactions in different physiological systems are provided.

TL;DR: The results indicate thatKYNA plays a protective role by down-regulating Bax expression and maintaining mitochondrial function in MPP(+)-induced neuronal cell death, and suggest that KYNA may have therapeutic potential in PD.

TL;DR: It is demonstrated that H1R, H2R and H4R are expressed in colon carcinoma and the adjacent normal mucosa and the results suggest a dramatic alteration in the distribution of histamine receptors in colon cancer.